Zobrazeno 1 - 10
of 479
pro vyhledávání: '"Christoph K. Weber"'
Autor:
Thomas Wirth, Bernd Baumann, T. Aleksic, Götz von Wichert, Christoph K. Weber, Guido Adler, Martin Wagner
Publikováno v:
Journal of Clinical Investigation. 117:1502-1513
Activation of the inhibitor of NF-kappaB kinase/NF-kappaB (IKK/NF-kappaB) system and expression of proinflammatory mediators are major events in acute pancreatitis. However, the in vivo consequences of IKK activation on the onset and progression of a
Publikováno v:
Gut. 56:227-236
Background: Activation of the nuclear factor κB (NF-κB) system is a major event in acute and chronic inflammatory processes. NF-κB cascades are comprised of IκB kinases, IκBs and NF-κB dimers. Little is known of the individual roles of these pr
Publikováno v:
Zeitschrift für Gastroenterologie. 41
Publikováno v:
Zeitschrift für Gastroenterologie. 41
Autor:
Christoph K, Weber, Guido, Adler
Publikováno v:
Current Opinion in Gastroenterology. 19:447-450
Acute pancreatitis is associated with significant morbidity and a mortality rate of approximately 8%. In severe pancreatitis, necrosis at the site of inflammation and remote organ failure develop in the course of disease. Pancreatic injury is initiat
Autor:
Yusuke Tando, Michael Beil, Roland M. Schmid, Günter Schneider, Hana Algül, Christoph K. Weber, Guido Adler, Claus Von Weyhern
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 283:G270-G281
The eukaryotic transcription factor nuclear factor-kappaB (NF-kappaB)/Rel is activated by a large variety of stimuli. It has been demonstrated that NF-kappaB/Rel is induced during the course of cerulein pancreatitis. Here, we show that NF-kappaB/Rel
Autor:
Ulf R. Rapp, Sybille Mazurek, Christoph K. Weber, Erich Eigenbrodt, Roland Houben, Carsten Hagemann, Jürgen Beigel, Ulrich Frey, Jakob Troppmair, Véronique Le Mellay, Roland Benz
Publikováno v:
Advances in Enzyme Regulation. 42:317-332
Autor:
Guido Adler, Martin Wagner, Torsten Mattfeldt, Florian R. Greten, Horst F. Kern, Stefan Koschnick, Wolfgang Deppert, Christoph K. Weber, Roland M. Schmid
Publikováno v:
Genes & Development. 15:286-293
This study describes a tumor progression model for ductal pancreatic cancer in mice overexpressing TGF-α. Activation of Ras and Erk causes induction of cyclin D1-Cdk4 without increase of cyclin E or PCNA in ductal lesions. Thus, TGF-α is able to pr
Autor:
Martin Wagner, Ulrich Zechner, Guido Adler, Christoph K. Weber, Roland M. Schmid, Florian R. Greten
Publikováno v:
Pancreatology. 1:363-368
Pancreatic cancer is a devastating disease with a fatal prognosis due to late diagnosis and resistance to radiation and chemotherapy. The average survival after diagnosis is still 3 to 8 months. In the last few years genetic alterations in cancer-cau
Autor:
Christoph K. Weber, Guido Adler
Publikováno v:
Pancreatology. 1:356-362
Acute pancreatitis represents a local inflammatory disorder with severe systemic consequences. Significant progress in understanding the pathophysiology of acute pancreatitis has been achieved in recent years. However, there is no clear concept about