Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Christoph J, Blohmke"'
Autor:
Jayaum S. Booth, Rekha R. Rapaka, Monica A. McArthur, Stephanie Fresnay, Thomas C. Darton, Christoph J. Blohmke, Claire Jones, Claire S. Waddington, Myron M. Levine, Andrew J. Pollard, Marcelo B. Sztein
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Despite decades of intense research, our understanding of the correlates of protection against Salmonella Typhi (S. Typhi) infection and disease remains incomplete. T follicular helper cells (TFH), an important link between cellular and humoral immun
Externí odkaz:
https://doaj.org/article/2584ad89ecfd40c2bb661c8fb10159e5
Autor:
Henderson Zhu, Irina Chelysheva, Deborah L. Cross, Luke Blackwell, Celina Jin, Malick M. Gibani, Elizabeth Jones, Jennifer Hill, Johannes Trück, Dominic F. Kelly, Christoph J. Blohmke, Andrew J. Pollard, Daniel O’Connor
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 16 (2023)
BACKGROUND Typhoid fever is caused by the Gram-negative bacterium Salmonella enterica serovar Typhi and poses a substantial public health burden worldwide. Vaccines have been developed based on the surface Vi-capsular polysaccharide of S. Typhi; thes
Externí odkaz:
https://doaj.org/article/b81e2d3d809c4b209e52887756c00f03
Autor:
Sonia Budroni, Francesca Buricchi, Andrea Cavallone, Gianfranco Volpini, Alessandra Mariani, Paola Lo Surdo, Christoph J. Blohmke, Giuseppe Del Giudice, Duccio Medini, Oretta Finco
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3664-3672 (2021)
Affinity measurement is a fundamental step in the discovery of monoclonal antibodies (mAbs) and of antigens suitable for vaccine development. Innovative affinity assays are needed due to the low throughput and/or limited dynamic range of available te
Externí odkaz:
https://doaj.org/article/23582833267946899d70dc3179517435
Autor:
Serena Tondi, Bruna Clemente, Carmen Esposito, Chiara Sammicheli, Simona Tavarini, Laura B. Martin, Omar Rossi, Francesca Micoli, Erika Bartolini, Michela Brazzoli, Cristina Ulivieri, Christoph J. Blohmke, Francesca Schiavetti
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Generalized Modules for Membrane Antigens (GMMA) are outer membrane exosomes purified from Gram-negative bacteria genetically mutated to increase blebbing and reduce risk of reactogenicity. This is commonly achieved through modification of the lipid
Externí odkaz:
https://doaj.org/article/6879890e38e54d8282d3f728473d5484
Autor:
Christoph J Blohmke, Julius Muller, Malick M Gibani, Hazel Dobinson, Sonu Shrestha, Soumya Perinparajah, Celina Jin, Harri Hughes, Luke Blackwell, Sabina Dongol, Abhilasha Karkey, Fernanda Schreiber, Derek Pickard, Buddha Basnyat, Gordon Dougan, Stephen Baker, Andrew J Pollard, Thomas C Darton
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp 1-16 (2019)
Abstract Misdiagnosis of enteric fever is a major global health problem, resulting in patient mismanagement, antimicrobial misuse and inaccurate disease burden estimates. Applying a machine learning algorithm to host gene expression profiles, we iden
Externí odkaz:
https://doaj.org/article/7ea3698836af4155880bcbcd299c5d0e
Autor:
Deborah L. Cross, Marije K. Verheul, Michael D. Leipold, Gerlinde Obermoser, Celina Jin, Elizabeth Jones, Joshua S. Starr, Irina Mohorianu, Christoph J. Blohmke, Holden T. Maecker, Giorgio Napolitani, Jennifer Hill, Andrew J. Pollard
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Vi-polysaccharide conjugate vaccines are efficacious against cases of typhoid fever; however, an absolute correlate of protection is not established. In this study, we investigated the leukocyte response to a Vi-tetanus toxoid conjugate vaccine (Vi-T
Externí odkaz:
https://doaj.org/article/18154f04f8854243816e5256d03d16db
Autor:
Malick M Gibani, Celina Jin, Sonu Shrestha, Maria Moore, Lily Norman, Merryn Voysey, Elizabeth Jones, Luke Blackwell, Helena Thomaides-Brears, Jennifer Hill, Christoph J Blohmke, Hazel C Dobinson, Philip Baker, Claire Jones, Danielle Campbell, Yama F Mujadidi, Emma Plested, Lorena Preciado-Llanes, Giorgio Napolitani, Alison Simmons, Melita A Gordon, Brian Angus, Thomas C Darton, Vincenzo Cerundulo, Andrew J Pollard
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008783 (2020)
Enteric fever is a systemic infection caused by Salmonella Typhi or Paratyphi A. In many endemic areas, these serovars co-circulate and can cause multiple infection-episodes in childhood. Prior exposure is thought to confer partial, but incomplete, p
Externí odkaz:
https://doaj.org/article/f70f1ff1116542f5a775b4d8d3b849ca
Autor:
Yan Zhang, Arthur Brady, Cheron Jones, Yang Song, Thomas C. Darton, Claire Jones, Christoph J. Blohmke, Andrew J. Pollard, Laurence S. Magder, Alessio Fasano, Marcelo B. Sztein, Claire M. Fraser
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT Insights into disease susceptibility as well as the efficacy of vaccines against typhoid and other enteric pathogens may be informed by better understanding the relationship between the effector immune response and the gut microbiota. In the
Externí odkaz:
https://doaj.org/article/544db5e9874840318d38f19327f53171
Autor:
Helene B. Juel, Helena B. Thomaides-Brears, Thomas C. Darton, Claire Jones, Elizabeth Jones, Sonu Shrestha, Rebecca Sie, Andrew Eustace, Ushma Galal, Prathiba Kurupati, Tan T. Van, Nga T. V. Thieu, Stephen Baker, Christoph J. Blohmke, Andrew J. Pollard
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
Effective vaccines against Salmonella Typhi, a major cause of febrile illness in tropical regions, can have a significant effect as a disease control measure. Earlier work has shown that immunization with either of two Salmonella Typhi vaccines, lice
Externí odkaz:
https://doaj.org/article/ec4e2debbc1e481aba8e1564ed91b16c
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Human challenge models, in which volunteers are experimentally infected with a pathogen of interest, provide the opportunity to directly identify both natural and vaccine-induced correlates of protection. In this review, we highlight how the applicat
Externí odkaz:
https://doaj.org/article/7a899e1e225d46ff83f0724d05005122