Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christoph Huwe"'
Autor:
Joanita Jakana, Christoph Huwe, Xiaojun Li, Jeng-Yih Chang, Zhicheng Cui, James C. Sacchettini, Ran Meng, Junjie Zhang, Lijun Duan, Jirapat Thongchol, Kailu Yang
Publikováno v:
Nucleic Acids Research
Ribosomes from Mycobacterium tuberculosis (Mtb) possess species-specific ribosomal RNA (rRNA) expansion segments and ribosomal proteins (rProtein). Here, we present the near-atomic structures of the Mtb 50S ribosomal subunit and the complete Mtb 70S
Publikováno v:
Angewandte Chemie. 125:2748-2751
Publikováno v:
Angewandte Chemie International Edition. 52:2684-2687
Publikováno v:
Angewandte Chemie. 123:7590-7592
Autor:
Christoph Huwe, Hermann Künzer
Publikováno v:
Tetrahedron Letters. 40:683-686
Commercially available (±)-α-lipoic acid was employed as a novel, chemically robust linker for the immobilization of ketones. The utility of this thioacetal based linker in solid-phase synthesis was demonstrated by synthesizing several 4-acetylbiph
Publikováno v:
Angewandte Chemie (International ed. in English). 50(33)
Autor:
Hartmut Rehwinkel, Christoph Huwe, Markus Berger, Stefan Jaroch, Heike Schäcke, Werner Skuballa, Konrad Krolikiewicz, Norbert Schmees
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(19)
The dissociated glucocorticoid receptor (GR) agonist ZK 216348 is rendered GR-selective over other nuclear hormone receptors through replacing the methylbenzoxazine with a quinoline moiety. Compounds were shown to be efficacious in cell assays with r
Autor:
Gary Phillips, Rebecca Pulk, Christopher W. West, Danny Arnaiz, Shendong Yuan, Kieu Chu, Marc Adler, David R. Light, Deborah Chen, Elena Ho, Giovanna Gualtieri, Marc Whitlow, Christoph Huwe, Judi Bryant, Drew Sukovich
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(19)
In this Letter we report the synthesis and evaluation of a series of non-amidine inhibitors of Urokinase Plasminogen Activator (uPA). Starting from compound 1, a significant change provided compounds in which the amidine, binding in the S1 pocket, wa
Autor:
Christoph Huwe
Publikováno v:
Drug discovery today. 11(15-16)
Compound libraries have an important role in the drug discovery process. Various computational methods are available as decision support tools for medicinal chemists involved in compound library synthesis programs. These methods can be used to assemb
Publikováno v:
Angewandte Chemie International Edition. 50:7452-7453