Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christoph Hohn"'
Autor:
F. Wieland Goetzke, Tobias Hüfner-Wulsdorf, François Diederich, Christoph Hohn, Klaus Reuter, F.R. Ehrmann, Maurice Sebastiani, Adrian Härtsch, E. Hassaan, Gerhard Klebe, Levon D. Movsisyan
Publikováno v:
Journal of Medicinal Chemistry, 63 (13)
Fragment-based lead discovery was applied to tRNA-guanine transglycosylase, an enzyme modifying post-transcriptionally tRNAs in Shigella, the causative agent of shigellosis. TGT inhibition prevents translation of Shigella's virulence factor VirF, hen
Publikováno v:
Nature Chemistry. 12:629-637
Polyketide natural products are an important class of biologically active compounds. Although substantial progress has been made on the synthesis of repetitive polyketide motifs through the iterative application of a single reaction type, synthetic a
Autor:
Meike Schöll, Christoph Höhn, Johannes Boucsein, Felix Moek, Jasper Plath, Maria an der Heiden, Matthew Huska, Stefan Kröger, Sofia Paraskevopoulou, Claudia Siffczyk, Udo Buchholz, Raskit Lachmann
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 4, Pp 711-720 (2024)
To examine the risk associated with bus riding and identify transmission chains, we investigated a COVID-19 outbreak in Germany in 2021 that involved index case-patients among bus-riding students. We used routine surveillance data, performed laborato
Externí odkaz:
https://doaj.org/article/f04ac09577c749f8afe24fd0db76a21d
Publikováno v:
Angewandte Chemie. 130:13098-13102
A protocol for the asymmetric synthesis of highly substituted chiral allenes with control of point and axial chirality has been developed. A palladium-catalyzed [3+2] cycloaddition using readily available racemic allenes gives access to densely funct
Publikováno v:
Nature chemistry. 12(7)
Polyketide natural products are an important class of biologically active compounds. Although substantial progress has been made on the synthesis of repetitive polyketide motifs through the iterative application of a single reaction type, synthetic a
Autor:
Marc Heinrich, Shiyan Xu, Barry M. Trost, Craig Stivala, Jullien Rey, Caroline Poock, Christoph Hohn, Wen-Ju Bai
Publikováno v:
Journal of the American Chemical Society. 140(49)
The synthesis of des-epoxy-amphidinolide N was achieved in 22 longest linear and 33 total steps. Three generations of synthetic endeavors are reported herein. During the first generation, our key stitching strategy that highlighted an intramolecular
Autor:
Andreas Heine, Gerhard Klebe, M. Neeb, Christoph Hohn, Adrian Härtsch, François Diederich, F.R. Ehrmann
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:4900-4910
Small-molecule ligands binding with partial disorder or enhanced residual mobility are usually assumed as unfavorable with respect to their binding properties. Considering thermodynamics, disorder or residual mobility is entropically favorable and co
Autor:
Christoph Hohn, François Diederich, Nils Trapp, F.R. Ehrmann, Oliver Dumele, Gerhard Klebe, Adrian Härtsch, Toni Pfaffeneder
Publikováno v:
Chemistry - A European Journal. 22:6750-6754
Shigellosis is one of the most severe diarrheal diseases worldwide without any efficient treatment so far. The enzyme tRNA-guanine transglycosylase (TGT) has been identified as a promising target for small-molecule drug design. Herein, we report a tr
Autor:
Christoph Hohn, Andreas Heine, F.R. Ehrmann, Klaus Reuter, Bruno Bernet, Gerhard Klebe, Thomas Botzanowski, Elisabeth Schäfer, François Diederich, Sarah Cianférani, Jorna Kalim, Toni Pfaffeneder
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2018, 57 (32), pp.10085-10090. ⟨10.1002/anie.201804627⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2018, 57 (32), pp.10085-10090. ⟨10.1002/anie.201804627⟩
International audience; The enzyme tRNA‐guanine transglycosylase, a target to fight Shigellosis, recognizes tRNA only as a homodimer and performs full nucleobase exchange at the wobble position. Active‐site inhibitors block the enzyme function by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f67b5a532901a82caf141467186d2b6
https://hal.archives-ouvertes.fr/hal-02341508
https://hal.archives-ouvertes.fr/hal-02341508
Autor:
Gerhard Klebe, M. Neeb, Shun Kojima, Christoph Hohn, Torsten Steinmetzer, Stefan Grüner, Frank Sielaff, François Diederich, Luzi Jakob Barandun
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1840:2843-2850
Background The thermodynamic characterization of protein–ligand interactions by isothermal titration calorimetry (ITC) is a powerful tool in drug design, giving valuable insight into the interaction driving forces. ITC is thought to require protein