Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Christoph Hofmann"'
Autor:
Christoph Hofmann, Adrian Serafin, Ole M Schwerdt, Fereshteh S Younesi, Florian Sicklinger, Ingmar Sören Meyer, Ellen Malovrh, Clara Sandmann, Lonny Jürgensen, Verena Kamuf-Schenk, Claudia Stroh, Zoe Löwenthal, Mandy Rettel, Frank Stein, Hugo A. Katus, Tobias Jakobi, Norbert Frey, Florian Leuschner, Mirko Völkers
RationaleRapid reperfusion is the most effective treatment for attenuating cardiac injury caused by myocardial ischemia. Yet, reperfusion itself elicits damage to the myocardium through incompletely understood mechanisms, known as ischemia/reperfusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b525252149d2c5bbda14b71af7c2e4ad
https://doi.org/10.1101/2022.07.25.501397
https://doi.org/10.1101/2022.07.25.501397
Autor:
Ayse Sanlialp, Shirin Doroudgar, Leon Kiper, Frank Zimmermann, Agnieszka A. Gorska, Sascha Dlugosz, Hugo A. Katus, Mirko Völkers, Jana Burghaus, Eshita Varma, Dagmar Schumacher, Juan E. Camacho Londoño, Marc Freichel, Eva Riechert, Vivien Kmietczyk, Angela Wirth, Thanh Cao Ho, Christoph Hofmann
Publikováno v:
Journal of Molecular and Cellular Cardiology. 141:30-42
Pathological cardiac hypertrophy is an independent risk for heart failure (HF) and sudden death. Deciphering signaling pathways regulating intracellular Ca2+ homeostasis that control adaptive and pathological cardiac growth may enable identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c392b0788d106856889220a5a0006b1a
https://doi.org/10.1016/j.yjmcc.2020.03.004
https://doi.org/10.1016/j.yjmcc.2020.03.004
Autor:
Agnieszka Górska, Clara Sandmann, Eva Riechert, Christoph Hofmann, Ellen Malovrh, Eshita Varma, Vivien Kmietczyk, Lonny Jürgensen, Verena Kamuf-Schenk, Claudia Stroh, Jennifer Furkel, Matthias Konstandin, Carsten Sticht, Etienne Boileau, Christoph Dieterich, Hugo Katus, Norbert Frey, Mirko Völkers
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:93
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b89e218af0cec3bfd2d19cd6250a05c
https://doi.org/10.1016/j.yjmcc.2022.08.187
https://doi.org/10.1016/j.yjmcc.2022.08.187
Autor:
Christoph Hofmann, Julia Groß, Jakobi T, Hugo A. Katus, Blackwood Ea, Doroudgar S, Clara Sandmann, Randal J. Kaufman, Glembotski Cc, Mirko Völkers, Nicole Herzog
Cardiac myocyte death during heart failure is particularly detrimental, given that cardiac muscle exhibits limited regenerative potential. Protein aggregation was previously observed in end-stage heart failure, suggesting protein-misfolding in cardia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::985c81f9c7ca020861a3a412562c9f86
https://doi.org/10.1101/2021.06.16.448596
https://doi.org/10.1101/2021.06.16.448596
Publikováno v:
Circulation. 139:2085-2088
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ddc4b472b556b08019e7da28fd7690
https://doi.org/10.1161/circulationaha.118.037417
https://doi.org/10.1161/circulationaha.118.037417
Autor:
Clara Sandmann, Vivien Kmietczyk, Shirin Doroudgar, Carsten Sticht, Eva Riechert, Eshita Varma, M. Konstandin, Claudia Stroh, Jennifer Furkel, Verena Kamuf-Schenk, Hugo A. Katus, Lonny Juergensen, Ellen Malovrh, Agnieszka A. Gorska, Christoph Hofmann, Mirko Völkers, Christoph Dieterich, Etienne Boileau
The mechanistic target of rapamycin (mTOR) is a key regulator of pathological remodeling in the heart by activating ribosomal biogenesis and mRNA translation. Inhibition of mTOR in cardiomyocytes is protective, however, a detailed role of mTOR in tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e491c64b16a6be24f30139103725a0e
https://doi.org/10.1101/2020.11.29.403196
https://doi.org/10.1101/2020.11.29.403196
Publikováno v:
LCN
Software Defined Networking (SDN) is established as a widely used concept in networks and has been introduced into the network architecture of Industrial Internet of Things (IIoT). Adversaries targeting on disrupting the operation of an IIoT system c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f74bfdf684364a44c403a775a1d6399
https://doi.org/10.1109/lcn48667.2020.9314854
https://doi.org/10.1109/lcn48667.2020.9314854
Autor:
Matthias W. Hentze, Mandy Rettel, Mercedes Fernandez, Eshita Varma, Hugo A. Katus, Mirko Völkers, Marta Ramirez-Pedraza, Frank Stein, Lonny Jürgensen, Eva Riechert, Raúl Méndez, Thileepan Sekaran, Thomas Schwarzl, Judit Martin, Christoph Hofmann, Verena Kamuf-Schenk
Publikováno v:
SSRN Electronic Journal.
RNA binding proteins (RBPs) have the potential to affect most post-transcriptional steps in gene expression. RBPs control critical elements of cellular function, but their specific role in cardiomyocytes is largely unknown. Here we defined RBPs in he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86dcc0e641fd4b25cd64a2a7f8463d50
https://doi.org/10.2139/ssrn.3647257
https://doi.org/10.2139/ssrn.3647257
Autor:
Christopher C. Glembotski, Donna J. Thuerauf, Erik A Blackwood, Asal G Fahem, Randal J. Kaufman, Christoph Hofmann, Shirin Doroudgar, Khalid Azizi, Jung-Kang Jin
Publikováno v:
Circulation Research. 120:862-875
Rationale: Endoplasmic reticulum (ER) stress causes the accumulation of misfolded proteins in the ER, activating the transcription factor, ATF6 (activating transcription factor 6 alpha), which induces ER stress response genes. Myocardial ischemia ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb85d2763cbbbe61e039c6d54d7014b
https://doi.org/10.1161/circresaha.116.310266
https://doi.org/10.1161/circresaha.116.310266
Autor:
Christoph Hofmann, Mirko Völkers, Christoph Dieterich, Fereshteh S Younesi, Ole M Schwerdt, Etienne Bioleau, Hugo A. Katus
Publikováno v:
Circulation Research. 125
Introduction: Since transcription is a relatively slow process, translation of preexisting mRNA networks might affect cardiac gene expression thereby rapidly adapting the myocardium to stress before changes in transcription take place. The mTOR kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::544c03526b61a2d4710c6a7d0f3dfde7
https://doi.org/10.1161/res.125.suppl_1.324
https://doi.org/10.1161/res.125.suppl_1.324