Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Christoph Hoenke"'
Autor:
Thomas Scott, Christian Alan Paul Smethurst, Yvonne Westermaier, Moriz Mayer, Peter Greb, Roland Kousek, Tobias Biberger, Gerd Bader, Zuzana Jandova, Philipp S. Schmalhorst, Julian E. Fuchs, Aniket Magarkar, Christoph Hoenke, Thomas Gerstberger, Steven A. Combs, Richard Pape, Saksham Phul, Sandeepkumar Kothiwale, Andreas Bergner, Alex G. Waterson, Foldit Players, Harald Weinstabl, Darryl B. McConnell, Jark Böttcher, Jens Meiler, Rocco Moretti
Given the role of human intuition in current drug design efforts, crowd-sourced 'citizen scientist' games have the potential to greatly expand the pool of potential drug designers. Here, we introduce ‘Drugit', the small molecule design mode of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::287b3949d9d0ebf819f483d064d56529
https://doi.org/10.26434/chemrxiv-2023-lczzd
https://doi.org/10.26434/chemrxiv-2023-lczzd
Publikováno v:
European Journal of Organic Chemistry. 2010:1745-1753
Orthogonally N-protected (Boc and Cbz) 4-(1,2,3-triazol-4-yl)-substituted 3-aminopiperidines are new scaffolds for combinatorial chemistry. They were prepared from a piperidine building block by a sequence of nucleophilic aziridine ring opening with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6df01908cab3f9aea6d94d57c8716418
https://doi.org/10.1002/ejoc.200901458
https://doi.org/10.1002/ejoc.200901458
Autor:
Thierry Bouyssou, Christoph Hoenke, Ingo Konetzki, Klaus Rudolf, Christofer S. Tautermann, Andreas Schnapp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6640-6644
Novel beta(2)-agonists with a 5-hydroxy-4H-benzo[1,4]oxazin-3-one moiety as head group are described. Systematic chemical variations at the phenethylamine residue of these compounds lead to the discovery of compound 6m as potent, full agonist of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be6bc00b5b606f503f485471fe209f6
https://doi.org/10.1016/j.bmcl.2009.10.013
https://doi.org/10.1016/j.bmcl.2009.10.013
Autor:
Rebekka Pflantz, Mario Kricka, Jonas Sluiter, Jens Christoffers, Wolfgang Saak, Christoph Hoenke
Publikováno v:
European Journal of Organic Chemistry. 2009:5431-5436
Bi(NO3)3-catalyzed ring expansion of five-membered ring 1,4-diketones in the presence of primary amines leads to eight-membered ring lactams. When applied to starting materials with a tetrahydrothiophene or pyrrolidine moiety, tetrahydro-2H-1,4-thiaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef4935ddd9eab7ed06b837d72eccc03d
https://doi.org/10.1002/ejoc.200900825
https://doi.org/10.1002/ejoc.200900825
Autor:
Thierry Bouyssou, Andreas Schnapp, Klaus Rudolf, Philipp Lustenberger, Christoph Hoenke, Ingo Konetzki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5237-5240
β2-Adrenoceptor agonists with basic and acidic groups attached via an alkyl linker to the phenyl ethanolamine core were prepared and investigated in vitro and in vivo. The compounds exhibited a high potency in a functional cellular assay and a bronc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cac584f703ec1b31176bfcb7764c9c1
https://doi.org/10.1016/j.bmcl.2009.06.104
https://doi.org/10.1016/j.bmcl.2009.06.104
Publikováno v:
Synthesis. 2009:1659-1662
Orthogonally N-protected (Boc and Cbz) 3,4-aziridinopiperidine is a versatile building block for the synthesis of 4-substituted 3-aminopiperidines, which are compounds with a high potential for biological activity. A multigram synthesis over five ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d7aff08365ab2df9a82e00d6d495af7
https://doi.org/10.1055/s-0028-1088059
https://doi.org/10.1055/s-0028-1088059
Publikováno v:
European Journal of Organic Chemistry. 2007:4376-4382
The Shapiro reaction of acetophenone is the key in a convenient three-step access to a divinyl ketone which is further transformed by double aza-Michael reactions with primary amines into N-substituted 3-phenyl-4-piperidones. In the case of N-benzyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d60372158bc3aafc6251825a6734a161
https://doi.org/10.1002/ejoc.200700325
https://doi.org/10.1002/ejoc.200700325
Publikováno v:
European Journal of Organic Chemistry. 2007:3227-3238
Eight-membered-ring lactams were prepared by the Bi-catalyzed reaction of 1,4-diketones with primary amines. These lactams define a new type of non-planar molecular scaffold with three points allowing for diversification, which were evaluated as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17310a34e4874b69ce33dc39905c528
https://doi.org/10.1002/ejoc.200700263
https://doi.org/10.1002/ejoc.200700263
Publikováno v:
Synthesis. :2357-2366
A new fragmentation reaction of 3-bromo-7-azabicy-clo[2.2.1]hepta-2,5-diene carboxylic esters with 2-amino or 2-aminomethyl anilines is described. It leads to cis-5-(benzimidazol-2-yl)- or cis-5-(3,4-dihydroquinazolin-2-yl)-pyrroline-2-acetic acid es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183f7dbd1de02f2e61a14b8ced573f44
https://doi.org/10.1055/s-2005-870011
https://doi.org/10.1055/s-2005-870011
Autor:
Peter R. Schreiner, Harlmut Rehwinkel, Carlo Unvergzagt, Volkhard Austel, Heinz Stadtmüller, Wolfgang Halfbrodt, Karamali Khanbabaee, Götz Bucher, Thomas Brumby, Christoph Hoenke, Andreas Gansäuer, Karsten Krohn, Stefan Peters
Publikováno v:
Nachrichten aus Chemie, Technik und Laboratorium. 46:156-181
Das intelligente Wechselspiel zwischen HighTech-Experiment und Theorie erlaubt die immer bessere Charakterisierung reaktiver Zwischenstufen und kleiner Molekule. Schwerpunkte der metallorganischen Chemie bleiben Ubergangsmetall- und Lewissaure-kataly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a13b040b13211e4ce3d4ec2b9082ff23
https://doi.org/10.1002/nadc.19980460211
https://doi.org/10.1002/nadc.19980460211