Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Christoph Hieber"'
Autor:
Christoph Hieber, Al-Hassan M. Mustafa, Sarah Neuroth, Sven Henninger, Hans-Peter Wollscheid, Joanna Zabkiewicz, Michelle Lazenby, Caroline Alvares, Siavosh Mahboobi, Falk Butter, Walburgis Brenner, Matthias Bros, Oliver H. Krämer
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117076- (2024)
Hyperactive FMS-like receptor tyrosine kinase-3 mutants with internal tandem duplications (FLT3-ITD) are frequent driver mutations of aggressive acute myeloid leukemia (AML). Inhibitors of FLT3 produce promising results in rationally designed cotreat
Externí odkaz:
https://doaj.org/article/92a388417b2242c48063d7ece8629a1e
Autor:
Vanessa Bolduan, Kim-Alicia Palzer, Christoph Hieber, Jenny Schunke, Michael Fichter, Paul Schneider, Stephan Grabbe, Andrea Pautz, Matthias Bros
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3884 (2024)
KH-type splicing regulatory protein (KSRP) is a single-stranded nucleic acid-binding protein with multiple functions. It is known to bind AU-rich motifs within the 3′-untranslated region of mRNA species, which in many cases encode dynamically regul
Externí odkaz:
https://doaj.org/article/df3d294a1f0045a3b7c14cf2da75a840
Publikováno v:
Cells, Vol 13, Iss 3, p 212 (2024)
Integrin receptors are heterodimeric surface receptors that play multiple roles regarding cell–cell communication, signaling, and migration. The four members of the β2 integrin subfamily are composed of an alternative α (CD11a–d) subunit, which
Externí odkaz:
https://doaj.org/article/684d200deee4492d92a6e5bb3d01733a
Autor:
Yanira Zeyn, Dominika Hobernik, Ulrich Wilk, Jana Pöhmerer, Christoph Hieber, Carolina Medina-Montano, Nadine Röhrig, Caroline F. Strähle, Andrea K. Thoma-Kress, Ernst Wagner, Matthias Bros, Simone Berger
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16938 (2023)
Deeper knowledge about the role of the tumor microenvironment (TME) in cancer development and progression has resulted in new strategies such as gene-based cancer immunotherapy. Whereas some approaches focus on the expression of tumoricidal genes wit
Externí odkaz:
https://doaj.org/article/bd7ceeae1cc8487cb44e56bfe6e58dc7
Autor:
Cristina Ortiz, Sabine Klein, Winfried H. Reul, Fernando Magdaleno, Stefanie Gröschl, Peter Dietrich, Robert Schierwagen, Frank E. Uschner, Sandra Torres, Christoph Hieber, Caroline Meier, Nico Kraus, Olaf Tyc, Maximilian Brol, Stefan Zeuzem, Christoph Welsch, Marco Poglitsch, Claus Hellerbrand, Mercedes Alfonso-Prieto, Fabio Mira, Ulrich auf dem Keller, Anja Tetzner, Andrew Moore, Thomas Walther, Jonel Trebicka
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112059- (2023)
Summary: Development of liver fibrosis is paralleled by contraction of hepatic stellate cells (HSCs), the main profibrotic hepatic cells. Yet, little is known about the interplay of neprilysin (NEP) and its substrate neuropeptide Y (NPY), a potent en
Externí odkaz:
https://doaj.org/article/5733bb5802fd4f15923c9bfe812518bf
Autor:
Nadine Bachtler, Sandra Torres, Cristina Ortiz, Robert Schierwagen, Olaf Tyc, Christoph Hieber, Marie-Luise Berres, Caroline Meier, Nico Kraus, Stefan Zeuzem, Bart Nijmeijer, Sebas Pronk, Jonel Trebicka, Sabine Klein
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0270288 (2023)
BackgroundThe Rho-kinase ROCK II plays a major role in the activation of hepatic stellate cells (HSC), which are the key profibrotic and contractile cells contributing to the development of chronic liver disease. Inhibition of ROCK II ultimately bloc
Externí odkaz:
https://doaj.org/article/4c3545d1400a45c989d504352b4d8006
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1085 (2023)
Aging attenuates the overall responsiveness of the immune system to eradicate pathogens. The increased production of pro-inflammatory cytokines by innate immune cells under basal conditions, termed inflammaging, contributes to impaired innate immune
Externí odkaz:
https://doaj.org/article/0d4722f83cf74e4480b04981c7d2e9aa
Autor:
Monika Bednarczyk, Vanessa Bolduan, Maximilian Haist, Henner Stege, Christoph Hieber, Lisa Johann, Carsten Schelmbauer, Michaela Blanfeld, Khalad Karram, Jenny Schunke, Tanja Klaus, Ingrid Tubbe, Evelyn Montermann, Nadine Röhrig, Maike Hartmann, Jana Schlosser, Tobias Bopp, Björn E Clausen, Ari Waisman, Matthias Bros, Stephan Grabbe
Publikováno v:
Cells, Vol 11, Iss 14, p 2188 (2022)
Heterodimeric β2 integrin surface receptors (CD11a-d/CD18) are specifically expressed by leukocytes that contribute to pathogen uptake, cell migration, immunological synapse formation and cell signaling. In humans, the loss of CD18 expression result
Externí odkaz:
https://doaj.org/article/dd3cdfc4fb2c4aa4ba1f88b6cdbadb3b
Autor:
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein
Publikováno v:
Hepatology : official journal of the American Association for the Study of Liver Diseases 77(4), 1228-1240 (2023). doi:10.1002/hep.32746
Hepatology : official journal of the American Association for the Study of Liver Diseases 77(4), 1228-1240 (2023). doi:10.1002/hep.32746
Published by Wolters Kluwer Health, [Alphen aan den Rijn]
Published by Wolters Kluwer Health, [Alphen aan den Rijn]
Autor:
Nico Kraus, Magnus Moeslein, Robert Schierwagen, Cristina Ortiz, Sandra Torres, Olaf Tyc, Christoph Hieber, Caroline Meier, Elena Müller, Frederik Holz, Wenyi Gu, Maximilian Brol, Stefan Zeuzem, FrankErhard Uschner, Jonel Trebicka, Sabine Klein
Publikováno v:
Zeitschrift für Gastroenterologie.