Výsledky vyhledávání - "Christoph Heyder"

Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL

Autor: D. Trapin, Ursula Denk, Alexander Egle, Christoph Heyder, Daniela Asslaber, Inge Tinhofer, Thomas Kocher, J. Piñón Hofbauer, Richard Greil, Claudia Holler

Publikováno v: Leukemia. 25:1452-1458

Chronic lymphocytic leukemia (CLL) cells require complex microenvironmental and immunologic interactions to survive and proliferate. Such interactions might be best recreated in animal models; however, this needs extensive verification. We therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e73f8a7490cfc31d144049a9abb92a
https://doi.org/10.1038/leu.2011.111

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PKCβ is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCβ as a therapeutic target in chronic lymphocytic leukemia

Autor: Ursula Denk, Christoph Heyder, Sebastian W. Hofbauer, Richard Greil, Alexander Egle, Josefina D. Piñón, Claudia Holler

Publikováno v: Blood. 113:2791-2794

The development and the propagation of chronic lymphocytic leukemia (CLL) has been linked to signaling via the B-cell receptor (BCR). Protein kinase C β (PKCβ) is an essential signaling element of the BCR and was recently shown to be overexpressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7e88f59100225a773525ffaabebb2c
https://doi.org/10.1182/blood-2008-06-160713

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Arsenic trioxide induces apoptosis preferentially in B-CLL cells of patients with unfavourable prognostic factors including del17p13

Autor: Christoph Heyder, Zlatko Trajanoski, Richard Greil, Daniela Asslaber, Christine Papak, Olaf Merkel, Claudia Holler, Inge Tinhofer, Andreas Prokesch, Markus Stöcher, Frank Hamacher, Marcel Scheideler

Publikováno v: Journal of Molecular Medicine. 86:541-552

In the last decade, arsenic trioxide (As2O3) has been used very successfully to treat acute promyelocytic leukaemia (APL). Much less is known about the effectiveness of As2O3 in other neoplastic disorders. In this paper, we report that after 18 h in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32509f7521adabda549190a1bb6134ca
https://doi.org/10.1007/s00109-008-0314-6

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Development and characterization of an innovative heparin coating to stabilize and protect liposomes against adverse immune reactions

Autor: Christoph Heyder, Karin Fromell, Kristina Nilsson Ekdahl, Gero Leneweit, Claudia Duehrkop, Katarina Edwards, Bo Nilsson

Publikováno v: Colloids and surfaces. B, Biointerfaces. 141

Liposomes have been recognized as excellent drug delivery systems, but when they come in direct contact with different blood components they may trigger an immediate activation of the innate immune system. The aim of the present study was to produce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ce1669165aca05e0a40a2bbf534be8
https://pubmed.ncbi.nlm.nih.gov/26897551

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3D-extravasation model – selection of highly motile and metastatic cancer cells

Autor: Eva Gloria-Maercker, Frank Entschladen, Dirk Kemming, Thomas Dittmar, Christoph Heyder, Wolfgang Hatzmann, Burkhard Brandt, Kurt S. Zänker, Antje Rötger

Publikováno v: Seminars in Cancer Biology. 15:387-395

Extravasation has been described as a rate-limiting step in the process of hematogeneous metastasis formation. Thereby, transendothelial migration of tumor cells consists of a complex series of events involving multiple cell-cell and cell-matrix inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae46870c3ea713c0262cea6995285514
https://doi.org/10.1016/j.semcancer.2005.06.006

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Role of the β1-integrin subunit in the adhesion, extravasation and migration of T24 human bladder carcinoma cells

Autor: Thomas Dittmar, Bernd Niggemann, Eva Gloria-Maercker, Wolfgang Hatzmann, Kurt S. Zänker, Christoph Heyder

Publikováno v: Clinical & Experimental Metastasis. 22:99-106

The abilities of tumor cells to extravasate from the blood vessel system and to migrate through the connective tissue are prerequisites in metastasis formation. Both processes are chiefly mediated by integrins, which mediate both cell-cell and cell-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4afb40c0e654c2bb19a7682f1a23af4
https://doi.org/10.1007/s10585-005-4335-z

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Adhesion molecules and chemokines: the navigation system for circulating tumor (stem) cells to metastasize in an organ-specific manner

Autor: Thomas Dittmar, Christoph Heyder, Eva Gloria-Maercker, Wolfgang Hatzmann, Kurt S. Zänker

Publikováno v: Clinicalexperimental metastasis. 25(1)

To date, cancer is still the second most prevalent cause of death after cardiovascular diseases in the industrialized word, whereby the primary cause of cancer is not attributed to primary tumor formation, but rather to the growth of metastases at di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8212f86aa49dde1013cfa6661bc99edb
https://pubmed.ncbi.nlm.nih.gov/17828597

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Visualization of tumor cell extravasation

Autor: Christoph, Heyder, Eva, Gloria-Maercker, Wolfgang, Hatzmann, Kurt S, Zaenker, Thomas, Dittmar

Publikováno v: Contributions to microbiology. 13

In cancer the blood-borne spread of tumor cells leads to the formation of secondary tumors at distant loci, whereby the extravasation of tumor cells is a prerequisite step during hematogenous metastasis. In regard to the fate of endothelial cells loc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::471c0a5ca972f6156ff6d8091261f724
https://pubmed.ncbi.nlm.nih.gov/16627967

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