Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Christoph Heier"'
Autor:
Peter Hofer, Gernot F. Grabner, Mario König, Hao Xie, Dominik Bulfon, Anton E. Ludwig, Heimo Wolinski, Robert Zimmermann, Rudolf Zechner, Christoph Heier
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100457- (2023)
Intracellular lipolysis—the enzymatic breakdown of lipid droplet-associated triacylglycerol (TAG)—depends on the cooperative action of several hydrolytic enzymes and regulatory proteins, together designated as lipolysome. Adipose triglyceride lip
Externí odkaz:
https://doaj.org/article/bfc34bab37db460bab35c37681986747
Autor:
Benedikt Kien, Stephanie Kolleritsch, Natalia Kunowska, Christoph Heier, Gabriel Chalhoub, Anna Tilp, Heimo Wolinski, Ulrich Stelzl, Guenter Haemmerle
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 3, Pp 100172- (2022)
Disturbances in lipid homeostasis can cause mitochondrial dysfunction and lipotoxicity. Perilipin 5 (PLIN5) decorates intracellular lipid droplets (LDs) in oxidative tissues and controls triacylglycerol (TG) turnover via its interactions with adipose
Externí odkaz:
https://doaj.org/article/e05474087d8548efb1423f0587febacb
Autor:
Lea Hänschke, Christoph Heier, Santiago José Maya Palacios, Huseyin Erdem Özek, Christoph Thiele, Reinhard Bauer, Ronald P. Kühnlein, Margret H. Bülow
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
The human LIPA gene encodes for the enzyme lysosomal acid lipase, which hydrolyzes cholesteryl ester and triacylglycerol. Lysosomal acid lipase deficiency results in Wolman disease and cholesteryl ester storage disease. The Drosophila genome encodes
Externí odkaz:
https://doaj.org/article/153473ccf6b24bffb4a99506d3235db3
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14983 (2022)
Lysophosphatidylcholine (LPC) is a bioactive lipid that modulates macrophage polarization during immune responses, inflammation, and tissue remodeling. Patatin-like phospholipase domain containing protein 7 (PNPLA7) is a lysophospholipase with a pref
Externí odkaz:
https://doaj.org/article/97dda3d0b3fa4a97802c4008b71ee333
Autor:
Philip Hehlert, Vinzenz Hofferek, Christoph Heier, Thomas O. Eichmann, Dietmar Riedel, Jonathan Rosenberg, Anna Takaćs, Harald M. Nagy, Monika Oberer, Robert Zimmermann, Ronald P. Kühnlein
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 8, Pp 1365-1378 (2019)
Triglycerides (TGs) are the main energy storage form that accommodates changing organismal energy demands. In Drosophila melanogaster, the TG lipase Brummer is centrally important for body fat mobilization. Its gene brummer (bmm) encodes the ortholog
Externí odkaz:
https://doaj.org/article/dce78dfb8c404957abac8ff09c6a819d
Autor:
Christoph Heier, Oskar Knittelfelder, Harald F Hofbauer, Wolfgang Mende, Ingrid Pörnbacher, Laura Schiller, Gabriele Schoiswohl, Hao Xie, Sebastian Grönke, Andrej Shevchenko, Ronald P Kühnlein
Publikováno v:
eLife, Vol 10 (2021)
Triacylglycerol (TG) and steryl ester (SE) lipid storage is a universal strategy to maintain organismal energy and membrane homeostasis. Cycles of building and mobilizing storage fat are fundamental in (re)distributing lipid substrates between tissue
Externí odkaz:
https://doaj.org/article/f44cb629f0a14f5886e00d24a7b6c7ad
Autor:
Zhiyuan Tang, Hao Xie, Christoph Heier, Jianfei Huang, Qiuling Zheng, Thomas O. Eichmann, Gabriele Schoiswohl, Jun Ni, Rudolf Zechner, Songshi Ni, Haiping Hao
Publikováno v:
EBioMedicine, Vol 53, Iss , Pp - (2020)
Background: Tumor cells display metabolic changes that correlate with malignancy, including an elevated hydrolysis of monoacylglycerol (MAG) in various cancer types. However, evidence is absent for the relationship between MAG lipolysis and NSCLC. Me
Externí odkaz:
https://doaj.org/article/68a37357a4c54ac3baf1e9aad0beb0f1
Autor:
Krishna M. Padmanabha Das, Lisa Wechselberger, Márton Liziczai, Montserrat De la Rosa Rodriguez, Gernot F. Grabner, Christoph Heier, Roland Viertlmayr, Claudia Radler, Jörg Lichtenegger, Robert Zimmermann, Jan Willem Borst, Rudolf Zechner, Sander Kersten, Monika Oberer
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 531-541 (2018)
Elaborate control mechanisms of intracellular triacylglycerol (TAG) breakdown are critically involved in the maintenance of energy homeostasis. Hypoxia-inducible lipid droplet-associated protein (HILPDA)/hypoxia-inducible gene-2 (Hig-2) has been show
Externí odkaz:
https://doaj.org/article/d3a7337d1d4c461c93352b99580f1a99
Autor:
Thomas O. Eichmann, Lukas Grumet, Ulrike Taschler, Jürgen Hartler, Christoph Heier, Aaron Woblistin, Laura Pajed, Manfred Kollroser, Gerald Rechberger, Gerhard G. Thallinger, Rudolf Zechner, Günter Haemmerle, Robert Zimmermann, Achim Lass
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 10, Pp 1972-1984 (2015)
Lipid droplets (LDs) of hepatic stellate cells (HSCs) contain large amounts of vitamin A [in the form of retinyl esters (REs)] as well as other neutral lipids such as TGs. During times of insufficient vitamin A availability, RE stores are mobilized t
Externí odkaz:
https://doaj.org/article/f2498427d99c463ab0fcfcdd48aab53a
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176980 (2017)
Acyltransferases catalyze essential reactions in the buildup and remodeling of glycerophospholipids and contribute to the maintenance and diversity of cellular membranes. Transmembrane protein 68 (TMEM68) is an evolutionarily conserved protein of unk
Externí odkaz:
https://doaj.org/article/dbefb2f18b2f4de5a3497702c0cbe009