Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Christoph H Mayr"'
Autor:
Christoph H Mayr, Lukas M Simon, Gabriela Leuschner, Meshal Ansari, Janine Schniering, Philipp E Geyer, Ilias Angelidis, Maximilian Strunz, Pawandeep Singh, Nikolaus Kneidinger, Frank Reichenberger, Edith Silbernagel, Stephan Böhm, Heiko Adler, Michael Lindner, Britta Maurer, Anne Hilgendorff, Antje Prasse, Jürgen Behr, Matthias Mann, Oliver Eickelberg, Fabian J Theis, Herbert B Schiller
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-22 (2021)
Abstract The correspondence of cell state changes in diseased organs to peripheral protein signatures is currently unknown. Here, we generated and integrated single‐cell transcriptomic and proteomic data from multiple large pulmonary fibrosis patie
Externí odkaz:
https://doaj.org/article/85b58d714e3046fa9fc4ca873ca79252
Autor:
Thomas Meul, Korbinian Berschneider, Sabine Schmitt, Christoph H. Mayr, Laura F. Mattner, Herbert B. Schiller, Ayse S. Yazgili, Xinyuan Wang, Christina Lukas, Camille Schlesser, Cornelia Prehn, Jerzy Adamski, Elisabeth Graf, Thomas Schwarzmayr, Fabiana Perocchi, Alexandra Kukat, Aleksandra Trifunovic, Laura Kremer, Holger Prokisch, Bastian Popper, Christine von Toerne, Stefanie M. Hauck, Hans Zischka, Silke Meiners
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108059- (2020)
Summary: The proteasome is the main proteolytic system for targeted protein degradation in the cell and is fine-tuned according to cellular needs. Here, we demonstrate that mitochondrial dysfunction and concomitant metabolic reprogramming of the tric
Externí odkaz:
https://doaj.org/article/777edfb804a34fd7bfeb044873d90981
Phosphoproteomics of cellular mechanosensing reveals NFATC4 as a regulator of myofibroblast activity
Autor:
Laura F. Mattner, Zhen Zeng, Christoph H. Mayr, Meshal Ansari, Xin Wei, Sara Asgharpour, Anita A. Wasik, Nikolaus Kneidinger, Mircea-Gabriel Stoleriu, Jürgen Behr, Julien Polleux, Ali Önder Yildirim, Gerald Burgstaller, Matthias Mann, Herbert B. Schiller
Feedback connections between tissue stiffness and cellular contractile forces can instruct cell identity and activity via a process referred to as mechanosensing. Specific phosphoproteome changes during mechanosensing are poorly characterized. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76a52b5795eb1544fa4b6f89b3e2f4e6
https://doi.org/10.1101/2023.02.13.528335
https://doi.org/10.1101/2023.02.13.528335
Autor:
Niklas J. Lang, Janine Gote-Schniering, Diana Porras-Gonzalez, Lin Yang, Laurens J. De Sadeleer, R. Christoph Jentzsch, Vladimir A. Shitov, Shuhong Zhou, Meshal Ansari, Ahmed Agami, Christoph H. Mayr, Baharak Hooshiar Kashani, Yuexin Chen, Lukas Heumos, Jeanine C. Pestoni, Emiel Geeraerts, Vincent Anquetil, Laurent Saniere, Melanie Wögrath, Michael Gerckens, Rudolf Hatz, Nikolaus Kneidinger, Jürgen Behr, Wim A. Wuyts, Mircea-Gabriel Stoleriu, Malte D. Luecken, Fabian J. Theis, Gerald Burgstaller, Herbert B. Schiller
Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered by the lack of organotypic models and analytical techniques. In this wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf1115a9d55d70a3b11582764ec1e5d4
https://doi.org/10.1101/2023.01.16.524219
https://doi.org/10.1101/2023.01.16.524219
Autor:
Olivier Burgy, Christoph H. Mayr, Beatriz Ballester Llobell, Arunima Sengupta, Déborah Schenesse, Christina Coughlan, Tanyalak Parimon, Peter Chen, Michael Lindner, Anne Hilgendorff, Matthias Mann, Ali Önder Yildirim, Oliver Eickelberg, Herbert B. Schiller, Mareike Lehmann, Gerald Burgstaller, Melanie Königshoff
Idiopathic pulmonary fibrosis (IPF) is a lethal and chronic lung disease characterized by aberrant intercellular communication, increased extracellular matrix (ECM) deposition, and destruction of functional lung tissue. Extracellular vesicles (EVs) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68a31cfb1b5f105c5100b9610805d9cb
https://doi.org/10.1101/2022.12.22.521499
https://doi.org/10.1101/2022.12.22.521499
Autor:
Niklas Lang, Meshal Ansari, Diana Porras-Gonzalez, Ahmed Agami, Baharak Hooshiar Kashani, Shuhong Zhou, Lin Yang, Michael Gerckens, Xin Wei, Christoph H. Mayr, Janine Schniering, Mircea-Gabriel Stoleriu, Rudolf Hatz, Jürgen Behr, Gerald Burgstaller, Herbert B. Schiller
Publikováno v:
03.03 - Mechanisms of lung injury and repair.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c54e2dfc7f70a87ebae9a6dca75d0f6
https://doi.org/10.1183/13993003.congress-2022.lsc-0072
https://doi.org/10.1183/13993003.congress-2022.lsc-0072
Autocrine Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts
Autor:
Christoph H. Mayr, Arunima Sengupta, Meshal Ansari, Jeanine C. Pestoni, Paulina Ogar, Ilias Angelidis, Andreas Liontos, Alberto Rodriguez-Castillo, Niklas J. Lang, Maximilian Strunz, Sara Asgharpour, Diana Porras-Gonzalez, Michael Gerckens, Bettina Oehrle, Valeria Viteri-Alvarez, Isis E. Fernandez, Michelle Tallquist, Martin Irmler, Johannes Beckers, Oliver Eickelberg, Gabriel Mircea Stoleriu, Jürgen Behr, Nikolaus Kneidinger, Ali Önder Yildirim, Katrin Ahlbrecht, Rory E. Morty, Christos Samakovlis, Fabian J. Theis, Gerald Burgstaller, Herbert B. Schiller
Fibroblast to myofibroblast conversion is a major driver of tissue remodeling in organ fibrosis. Several distinct lineages of fibroblasts support homeostatic tissue niche functions, yet, specific activation states and phenotypic trajectories of fibro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a71ef4386bf9ba8425663fdc42b3b85
https://doi.org/10.1101/2022.07.11.499594
https://doi.org/10.1101/2022.07.11.499594
Autor:
Maximilian Strunz, Paulina Ogar, Zhongming Zhao, Meshal Ansari, Herbert B. Schiller, Jens Neumann, Min Yee, Gerald Burgstaller, Marius Lange, I. V. Kukhtevich, Laura F. Mattner, Carola Voss, Ilias Angelidis, Arunima Sengupta, Michael A. O'Reilly, Robert J. Schneider, Christoph H. Mayr, Lukas M. Simon, Fabian J. Theis, Mareike Lehmann, Tobias Stoeger, Harold A. Chapman, Jürgen Behr, George Tsidiridis, Melanie Königshoff, Anne Hilgendorff, Jaymin J. Kathiriya
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptional dynamics for 28 cell types. Trajectory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13d526d4f406413d6495af1f39c7ad2
http://link.springer.com/article/10.1038/s41467-020-17358-3
http://link.springer.com/article/10.1038/s41467-020-17358-3
Autor:
Enzo Lüsebrink, Inas Saleh, René M'Pembele, Manuela Thienel, Philipp Mourikis, Franz Röschenthaler, Christoph H. Mayr, Lisa Dannenberg, Thomas J. Stocker, Kajetan Trojovky, Joachim Pircher, Christian Jung, Alina Achilles, Richard Brandl, Bodo Levkau, Till Hoffmann, Tobias Zeus, Zhe Zhang, Norbert Gerdes, Thomas Hohlfeld, Andreas Ehrlich, Michael Spannagl, Daniel Konsek, Malte Kelm, Carolin Helten, Christian Schulz, Ron Regenauer, Herbert B. Schiller, Jan Strecker, Aysel Ayhan, Leo Nicolai, Tobias Petzold, Amin Polzin
Publikováno v:
Circulation Research. 126:486-500
Rationale: A reduced rate of myocardial infarction has been reported in patients with atrial fibrillation treated with FXa (factor Xa) inhibitors including rivaroxaban compared with vitamin K antagonists. At the same time, low-dose rivaroxaban has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8bedea63187b550b56b521d05fccf5
https://doi.org/10.1161/circresaha.119.315099
https://doi.org/10.1161/circresaha.119.315099
Autor:
Janine Schniering, Mareike Lehmann, Meshal Ansari, Maria C. Melo Narvaez, Christoph H. Mayr, Yuexin Chen, Niklas J. Lang, Ahmed Agami, Baharak Hooshiar Kashani, Ilias Angelidis, Melanie Königshoff, Herbert B. Schiller
Publikováno v:
Molecular pathology and functional genomics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a72996953f2429d4134e175f43856e66
https://doi.org/10.1183/23120541.lsc-2022.70
https://doi.org/10.1183/23120541.lsc-2022.70