Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Christoph Grundner"'
Publikováno v:
PLoS Biology, Vol 20, Iss 11, p e3001906 (2022)
The mechanisms by which nutrients traverse the Mycobacterium tuberculosis (Mtb) outer membrane remain mostly unknown and, in the absence of classical porins, likely involve specialized transport systems. Calcium ions (Ca2+) are an important nutrient
Externí odkaz:
https://doaj.org/article/14803093b5dd472c810b6bc5e6d9f86d
Autor:
Christoph Grundner
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e3000037 (2018)
Tuberculosis (TB) is now the leading cause of death from infectious disease. On September 26, 2018, the United Nations (UN) General Assembly holds its first high-level meeting on TB, a once-in-a-lifetime chance to commit governments around the world
Externí odkaz:
https://doaj.org/article/5521961ea4a845a8bd087bff8efeb176
Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch.
Autor:
Corrie Ortega, Reiling Liao, Lindsey N Anderson, Tige Rustad, Anja R Ollodart, Aaron T Wright, David R Sherman, Christoph Grundner
Publikováno v:
PLoS Biology, Vol 12, Iss 1, p e1001746 (2014)
The majority of Mycobacterium tuberculosis (Mtb) infections are clinically latent, characterized by drug tolerance and little or no bacterial replication. Low oxygen tension is a major host factor inducing bacteriostasis, but the molecular mechanisms
Externí odkaz:
https://doaj.org/article/af629d4898f64f4490956e535809de40
Many aspects of eukaryotic physiology are regulated by calcium ions (Ca2+). Whether bacteria have similar Ca2+ systems for transport, storage, binding, and response to Ca2+ is not well understood. To identify components of Ca2+ signaling in Mycobacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1338695007f5a04d2f2de9e5f906454a
https://doi.org/10.1101/2022.05.30.494056
https://doi.org/10.1101/2022.05.30.494056
Autor:
Andrew Frando, Kyu Y. Rhee, Tige R. Rustad, David R. Sherman, Samuel J. Hobbs, Neil David Fleck, Christoph Grundner, Vijay Soni, Robert Morrison, Jessica Farrow-Johnson, Shuyi Ma
Publikováno v:
Nature microbiology
Transposon-based strategies provide a powerful and unbiased way to study the bacterial stress response1-8, but these approaches cannot fully capture the complexities of network-based behaviour. Here, we present a network-based genetic screening appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd91b52555380ac1e0621784f010e8d
https://doi.org/10.1038/s41564-020-00810-x
https://doi.org/10.1038/s41564-020-00810-x
Publikováno v:
Trends in Biochemical Sciences, 47, 9, pp. 785-794
Trends in Biochemical Sciences, 47, 785-794
Trends in Biochemical Sciences, 47, 785-794
Current tools to annotate protein function have failed to keep pace with the speed of DNA sequencing and exponentially growing number of proteins of unknown function (PUFs). A major contributing factor to this mismatch is the historical lack of high-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5717a364fa047e3bb6af6bf9d9ede9
https://repository.ubn.ru.nl/handle/2066/285534
https://repository.ubn.ru.nl/handle/2066/285534
Autor:
Christopher R. M. Asquith, Christoph Grundner, William J. Zuercher, Chad Torrice, Neil Fleck, Daniel J. Crona
Publikováno v:
Bioorg Med Chem Lett
We screened a series of 4-anilinoquinolines and 4-anilinoquinazolines and identified novel inhibitors of Mycobacterium tuberculosis (Mtb). The focused 4-anilinoquinoline/quinazoline scaffold arrays yielded compounds with high potency and the identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8c22bc9e45a18135b18fcc4bc00b88
https://doi.org/10.1016/j.bmcl.2019.07.012
https://doi.org/10.1016/j.bmcl.2019.07.012
Autor:
Neil Fleck, Christoph Grundner
The introduction of CRISPR interference (CRISPRi) has made gene repression in mycobacteria much more efficient, but technical challenges of the prototypical Cas9-based platform, for example in multigene regulation, remain. Here, we introduce an alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e1035f157498eb9d8cba3ea58da8ba9
https://doi.org/10.1101/2021.01.25.427309
https://doi.org/10.1101/2021.01.25.427309
Autor:
Joshua R. Hansen, Lindsey N. Anderson, Christoph Grundner, Erika L. Flannery, Neil Fleck, Richard D. Smith, Matthew Fishbaugher, Bobbie-Jo M. Webb-Robertson, Andrew Frando, Corrie Ortega, Aaron T. Wright, Taylor A. Murphree, Stefan H. I. Kappe
Publikováno v:
Molecular & Cellular Proteomics. 17:111-120
Effective malaria control and elimination in hyperendemic areas of the world will require treatment of the Plasmodium falciparum (Pf) blood stage that causes disease as well as the gametocyte stage that is required for transmission from humans to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e89835c9c915ce412e60055e749f88e3
https://doi.org/10.1074/mcp.ra117.000088
https://doi.org/10.1074/mcp.ra117.000088