Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christoph G. Goemans"'
Autor:
Luzheng Xue, Kanwar Virdee, Brian A Hemmings, Aviva M. Tolkovsky, Christoph G. Goemans, Rolf Heumann
Phosphoinositide 3-kinase and its downstream effector kinase PKB/Akt have been suggested to have crucial roles in suppressing apoptosis in several classes of neurons. However, few studies have conducted a long-term investigation of either kinase acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f9868640a6889e4a35272b1d864e0c
https://ora.ox.ac.uk/objects/uuid:d03d563d-ef49-4aa1-8bcf-cbff61fd60ac
https://ora.ox.ac.uk/objects/uuid:d03d563d-ef49-4aa1-8bcf-cbff61fd60ac
Autor:
Sascha Karassek, Carsten Berghaus, Christian Herrmann, Sebastian Neumann, Nadine Ohse, Katharina F. G. Jockers, Melanie Schwarten, Sebastian Gottfried, Christoph G. Goemans, Rolf Heumann, Gerd Kock, Raphael Stoll
Publikováno v:
The Journal of Biological Chemistry
Rheb is a homolog of Ras GTPase that regulates cell growth, proliferation, and regeneration via mammalian target of rapamycin (mTOR). Because of the well established potential of activated Ras to promote survival, we sought to investigate the ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551cf85865955f89747debac04b629cb
https://doi.org/10.1074/jbc.m109.095968
https://doi.org/10.1074/jbc.m109.095968
Autor:
Matthew A. King, Aviva M. Tolkovsky, Jochen H. M. Prehn, Farida Hafiz, Christoph G. Goemans, Andreas Wyttenbach
Publikováno v:
The Journal of Neuroscience. 28:14401-14415
Proteins containing extended polyglutamine repeats cause at least nine neurodegenerative disorders, but the mechanisms of disease-related neuronal death remain uncertain. We show that sympathetic neurons containing cytoplasmic inclusions formed by 97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1432357c4cf55fd83cacba8c45ab79
https://doi.org/10.1523/jneurosci.4751-08.2008
https://doi.org/10.1523/jneurosci.4751-08.2008
Autor:
Edward T. W. Bampton, Noboru Mizushima, Aviva M. Tolkovsky, Dhevahi Niranjan, Christoph G. Goemans
Publikováno v:
ResearcherID
Autophagy has been implicated in a range of disorders and hence is of major interest. However, imaging autophagy in real time has been hampered by lack of suitable markers. We have compared the potential of monodansylcadaverine, widely used as an aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13eeac646f62bf9bb556656673c60c6
https://doi.org/10.4161/auto.1.1.1495
https://doi.org/10.4161/auto.1.1.1495
Autor:
Frank Narz, Peter R. Allegrini, Christoph G. Goemans, Kurt Lingenhöhl, Hartmut Berns, Daniela Bartsch, Bastian Hengerer, Erwin F. Wagner, Rolf Heumann, Rigobert H. Kamdem, Thomas Arendt, Karl Schellander, Peter C. Waldmeier, Kirstin Obst-Pernberg, Petra Wahle
Publikováno v:
The Journal of Cell Biology
Ras is a universal eukaryotic intracellular protein integrating extracellular signals from multiple receptor types. To investigate its role in the adult central nervous system, constitutively activated V12-Ha-Ras was expressed selectively in neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7f9ec6f11c12860354c73aad119068
https://doi.org/10.1083/jcb.151.7.1537
https://doi.org/10.1083/jcb.151.7.1537
Autor:
Robert D. Goldin, Eleonora Lapi, Aviva M. Tolkovsky, Shan Zhong, Yihua Wang, You-Wen He, Indrika Ratnayaka, Xin Lu, Christoph G. Goemans, Wei Jia, Alexandra Sullivan, Xiao Dan Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(33)
RAS is frequently mutated in human cancers and has opposing effects on autophagy and tumorigenesis. Identifying determinants of the cellular responses to RAS is therefore vital in cancer research. Here, we show that autophagic activity dictates the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5d986da98151ec5735a76fefcb75d0
https://pubmed.ncbi.nlm.nih.gov/22847423
https://pubmed.ncbi.nlm.nih.gov/22847423
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 445
Macroautophagy (herein referred to as autophagy) contributes to the control of life and death throughout the animal and plant kingdoms. Bilateral links have been found between apoptosis and autophagy where inducers of apoptosis also induce autophagy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::551accc17f04050d9b5440ff2e594538
https://pubmed.ncbi.nlm.nih.gov/18425451
https://pubmed.ncbi.nlm.nih.gov/18425451
Publikováno v:
Autophagosome and Phagosome ISBN: 9781588298539
Macroautophagy (herein referred to as autophagy) contributes to the control of life and death throughout the animal and plant kingdoms. Bilateral links have been found between apoptosis and autophagy where inducers of apoptosis also induce autophagy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::575692a8986cb27a344dcd95c8dff393
https://doi.org/10.1007/978-1-59745-157-4_12
https://doi.org/10.1007/978-1-59745-157-4_12
Publikováno v:
When Cells Die II: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fde4efea555701772d6b7abcbb98cb0c
https://doi.org/10.1002/0471476501.ch8
https://doi.org/10.1002/0471476501.ch8
Autor:
Pietro Ghezzi, Tiziana Mennini, Maddalena Fratelli, Michael Brines, Simona Casagrande, Anthony Cerami, Sonja Keenan, Rolf Heumann, Piotr Lewczuk, Christoph H. Gleiter, Claudio Pasquali, Anna-Leena Sirén, Christoph G. Goemans, Hannelore Ehrenreich, Annalisa Capobianco
Erythropoietin (EPO) promotes neuronal survival after hypoxia and other metabolic insults by largely unknown mechanisms. Apoptosis and necrosis have been proposed as mechanisms of cellular demise, and either could be the target of actions of EPO. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b803d6c37462e6ac152d233d5c0b19e
https://europepmc.org/articles/PMC31176/
https://europepmc.org/articles/PMC31176/