Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Christoph Enzensperger"'
Autor:
Philipp Ernst, Adrian T. Press, Mike Fischer, Vivien Günther, Christine Gräfe, Joachim H. Clement, Thomas Ernst, Ulrich S. Schubert, Jana Wotschadlo, Marc Lehmann, Christoph Enzensperger, Michael Bauer, Andreas Hochhaus
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 372-381 (2020)
In chronic myelogenous leukemia (CML), treatment with tyrosine kinase inhibitors (TKI) is unable to eradicate leukemic stem cells (LSC). Polymethine dye-functionalized nanoparticles can be internalized by specific cell types using transmembrane carri
Externí odkaz:
https://doaj.org/article/67947521e5e3418a85f1055be7115221
Autor:
Blerina Shkodra, Adrian T. Press, Antje Vollrath, Ivo Nischang, Stephanie Schubert, Stephanie Hoeppener, Dorothee Haas, Christoph Enzensperger, Marc Lehmann, Petra Babic, Kay Jovana Benecke, Anja Traeger, Michael Bauer, Ulrich S. Schubert
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1110 (2020)
Bisindolylmaleimide I (BIM-I) is a competitive pan protein kinase C inhibitor with anti-inflammatory and anti-metastatic properties, suggested to treat inflammatory diseases and various cancer entities. However, despite its therapeutic potential, BIM
Externí odkaz:
https://doaj.org/article/239eaf11ef024de1bc10c5624c3ffef9
Autor:
Ulrich S. Schubert, Michael Bauer, Thomas Ernst, Jana Wotschadlo, Adrian T. Press, Marc Lehmann, Michael Fischer, Andreas Hochhaus, Christoph Enzensperger, Vivien Günther, Joachim H. Clement, Philipp Ernst, Christine Gräfe
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss, Pp 372-381 (2020)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
In chronic myelogenous leukemia (CML), treatment with tyrosine kinase inhibitors (TKI) is unable to eradicate leukemic stem cells (LSC). Polymethine dye-functionalized nanoparticles can be internalized by specific cell types using transmembrane carri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785676bc5afef4bba90d58cf2d25da8a
http://www.sciencedirect.com/science/article/pii/S237277052030111X
http://www.sciencedirect.com/science/article/pii/S237277052030111X
Autor:
Heinz Reichmann, Sebastian Keller, Gabriele Gille, Witold H Polanski, Andreas Hermann, Christoph Enzensperger
Publikováno v:
Journal of neural transmission 127(7), 999-1012 (2020). doi:10.1007/s00702-020-02189-9
Journal of Neural Transmission
Journal of Neural Transmission
β-Carbolines (BC) are pyridoindoles, which can be found in various exogenous and endogenous sources. Recent studies revealed neurostimulative, neuroprotective, neuroregenerative and anti-inflammatory effects of 9-methyl-BC (9-Me-BC). Additionally, 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518a4cdfa60dee7fc88933668b725820
https://pub.dzne.de/record/151649
https://pub.dzne.de/record/151649
Autor:
Witold H Polanski, Christoph Enzensperger, Andreas Hermann, Heinz Reichmann, Sebastian Keller, Gabriele Gille
Publikováno v:
Journal of neural transmission 129(1), 125 (2022). doi:10.1007/s00702-021-02433-w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4f562efde621bb9f50f6474fd69e3b
https://doi.org/10.1007/s00702-021-02433-w
https://doi.org/10.1007/s00702-021-02433-w
Autor:
Dina Robaa, Friedemann Gaube, Karl J. Föhr, Paul Warncke, Christian Fleck, Oliver Adolph, Christoph Enzensperger, Robert Penzis, Robert Otto, Jochen Lehmann, Thomas Winckler, Dorothea Appenroth
Publikováno v:
Journal of Medicinal Chemistry. 58:6710-6715
Neurodegenerative diseases represent a challenge for biomedical research due to their high prevalence and lack of mechanism-based treatments. Because of the complex pathology of neurodegenerative disorders, multifunctional drugs have been increasingl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fe2281f97c55ba9b0ef6776e13843d
https://doi.org/10.1021/acs.jmedchem.5b00958
https://doi.org/10.1021/acs.jmedchem.5b00958
Autor:
Jochen Lehmann, Peter Meinhard Dr. rer. nat. Schweikert, Ashraf H. Abadi, Christoph Enzensperger, Mohamed A. O. Abdel-Fattah
Publikováno v:
MedChemComm. 6:1679-1686
Designing ligands with D1/D5 subtype selectivity is a challenge because of the high identity within the receptor helices. Based on the lead compounds 1–3, the thieno-benzazecine regioisomers 4 and 5 were synthesized and biologically evaluated for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d15a70bf7d2ec3eaff50fdec43709350
https://doi.org/10.1039/c5md00258c
https://doi.org/10.1039/c5md00258c
Autor:
Hans-Dieter Arndt, Christian Fleck, Stephanie Zergiebel, Andreas Seeling, Christoph Enzensperger
Publikováno v:
Drug research. 67(8)
Dibenzo- and benzindolo-azecines represent a class of potential neuroleptics. To characterize the effectiveness at the dopamine and 5-HT2A-receptor representative structures were synthesized and tested by radio ligand binding studies, in vivo and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355a0bb8d2ef67b30de86fa8c779a041
https://pubmed.ncbi.nlm.nih.gov/28521372
https://pubmed.ncbi.nlm.nih.gov/28521372
Autor:
Christoph Enzensperger, Christian Tränkle, Christian Fleck, Robert Otto, Dorothea Appenroth, Jochen Lehmann, Thomas Winckler, Friedemann Gaube, Robert Penzis
Publikováno v:
European Journal of Medicinal Chemistry. 87:63-70
Nine novel β- and γ-carboline derivatives bearing either methyl-, propargyl- or phenethyl-residues at the indole nitrogen were synthesized and tested as potential anti-Alzheimer drugs. Antagonism of recombinantly expressed NMDA receptors, inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e390437c1d94743ea2f57043d5a4ca1b
https://doi.org/10.1016/j.ejmech.2014.09.048
https://doi.org/10.1016/j.ejmech.2014.09.048
Autor:
Robert E. Van Sciver, Ishan T. Shah, Jonathan A. Israel, Helen E. McGrath, Robin A. Felder, Christoph Enzensperger, John J Gildea, Pedro A. Jose
Publikováno v:
Kidney international
Determining the individual roles of the two dopamine D1-like receptors (D1R and D5R) on sodium transport in the human renal proximal tubule has been complicated by their structural and functional similarity. Here we used a novel D5R-selective antagon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a88f0414b238d69ff6a6183b23527f
https://doi.org/10.1038/ki.2014.5
https://doi.org/10.1038/ki.2014.5