Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Christoph Brenker"'
Autor:
Johannes Lorenz, Clara Eisenhardt, Teresa Mittermair, Alexandra E. Kulle, Paul Martin Holterhus, Manfred Fobker, Wolfgang Boenigk, Verena Nordhoff, Hermann M. Behre, Timo Strünker, Christoph Brenker
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
To locate and fertilize the egg, sperm probe the varying microenvironment prevailing at different stages during their journey across the female genital tract. To this end, they are equipped with a unique repertoire of mostly sperm-specific proteins.
Externí odkaz:
https://doaj.org/article/cc8187186afb40fb821db645251b8538
Autor:
Simon Schneider, Andjela Kovacevic, Michelle Mayer, Ann-Kristin Dicke, Lena Arévalo, Sophie A Koser, Jan N Hansen, Samuel Young, Christoph Brenker, Sabine Kliesch, Dagmar Wachten, Gregor Kirfel, Timo Strünker, Frank Tüttelmann, Hubert Schorle
Publikováno v:
eLife, Vol 12 (2023)
Cylicins are testis-specific proteins, which are exclusively expressed during spermiogenesis. In mice and humans, two Cylicins, the gonosomal X-linked Cylicin 1 (Cylc1/CYLC1) and the autosomal Cylicin 2 (Cylc2/CYLC2) genes, have been identified. Cyli
Externí odkaz:
https://doaj.org/article/d7b2c5f7a719474eb70622b7f2bb0821
Autor:
Michelina Kierzek, Parker E Deal, Evan W Miller, Shatanik Mukherjee, Dagmar Wachten, Arnd Baumann, U Benjamin Kaupp, Timo Strünker, Christoph Brenker
Publikováno v:
eLife, Vol 10 (2021)
Fluorescent probes that change their spectral properties upon binding to small biomolecules, ions, or changes in the membrane potential (Vm) are invaluable tools to study cellular signaling pathways. Here, we introduce a novel technique for simultane
Externí odkaz:
https://doaj.org/article/ff6c6b36dc74490c9dc0a6d1e5cee781
Autor:
Janice K. Jeschke, Cristina Biagioni, Tobias Schierling, Isabel Viola Wagner, Frederik Börgel, Dirk Schepmann, Andreas Schüring, Alexandra E. Kulle, Paul Martin Holterhus, Michael von Wolff, Bernhard Wünsch, Verena Nordhoff, Timo Strünker, Christoph Brenker
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The sperm-specific Ca2+ channel CatSper registers chemical cues that assist human sperm to fertilize the egg. Prime examples are progesterone and prostaglandin E1 that activate CatSper without involving classical nuclear and G protein-coupled recepto
Externí odkaz:
https://doaj.org/article/e93831ba22cc4ad688b87043d05ff3c8
Autor:
Melanie Balbach, Hussein Hamzeh, Jan F. Jikeli, Christoph Brenker, Christian Schiffer, Jan N. Hansen, Pia Neugebauer, Christian Trötschel, Luca Jovine, Ling Han, Harvey M. Florman, U. Benjamin Kaupp, Timo Strünker, Dagmar Wachten
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mammalian oocytes are enveloped by the zona pellucida (ZP), an extracellular matrix of glycoproteins. In sperm, stimulation with ZP proteins evokes a rapid Ca2+ influx via the sperm-specific, pH-sensitive Ca2+ channel CatSper. However, the physiologi
Externí odkaz:
https://doaj.org/article/87d6e04ca4ce4b2cb1e990ab3f22a423
Autor:
Elsie Amedonu, Christoph Brenker, Sumanta Barman, Julian A. Schreiber, Sebastian Becker, Stefan Peischard, Nathalie Strutz-Seebohm, Christine Strippel, Andre Dik, Hans-Peter Hartung, Thomas Budde, Heinz Wiendl, Timo Strünker, Bernhard Wünsch, Norbert Goebels, Sven G. Meuth, Guiscard Seebohm, Nico Melzer
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
N-Methyl-D-aspartate (NMDA) receptors (NMDARs) are among the most important excitatory neurotransmitter receptors in the human brain. Autoantibodies to the human NMDAR cause the most frequent form of autoimmune encephalitis involving autoantibody-med
Externí odkaz:
https://doaj.org/article/c459b4e8d59c4d2591a4219c1010af57
Autor:
Christoph Brenker, Yu Zhou, Astrid Müller, Fabio Andres Echeverry, Christian Trötschel, Ansgar Poetsch, Xiao-Ming Xia, Wolfgang Bönigk, Christopher J Lingle, U Benjamin Kaupp, Timo Strünker
Publikováno v:
eLife, Vol 3 (2014)
Sperm are equipped with a unique set of ion channels that orchestrate fertilization. In mouse sperm, the principal K+ current (IKSper) is carried by the Slo3 channel, which sets the membrane potential (Vm) in a strongly pHi-dependent manner. Here, we
Externí odkaz:
https://doaj.org/article/e83017a040674c3d9b166ab38e277594
Autor:
Tobias Schierling, Beatrice Tosi, Clara Eisenhardt, Sophie Reining, Constantin G. Daniliuc, Christoph Brenker, Timo Strünker, Bernhard Wünsch
Publikováno v:
ACS Pharmacology & Translational Science. 6:115-127
Autor:
Samuel Young, Christian Schiffer, Alice Wagner, Jannika Patz, Anton Potapenko, Leonie Herrmann, Verena Nordhoff, Tim Pock, Claudia Krallmann, Birgit Stallmeyer, Albrecht Röpke, Michelina Kierzek, Cristina Biagioni, Tao Wang, Lars Haalck, Dirk Deuster, Jan N Hansen, Dagmar Wachten, Benjamin Risse, Hermann M Behre, Stefan Schlatt, Sabine Kliesch, Frank Tüttelmann, Christoph Brenker, Timo Strünker
The infertility of many couples seems to rest on an enigmatic dysfunction of the men’s sperm, rendering early diagnosis and evidence-based treatment by medically assisted reproduction impossible. Using a novel laboratory test, we assessed the funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cda6c97bbe13cfd00563eab3092ff946
https://doi.org/10.1101/2023.03.23.23286813
https://doi.org/10.1101/2023.03.23.23286813
Autor:
Nadine Ritter, Paul Disse, Isabel Aymanns, Lena Mücher, Julian Alexander Schreiber, Christoph Brenker, Timo Strünker, Dirk Schepmann, Thomas Budde, Nathalie Strutz-Seebohm, Simon Mensah Ametamey, Bernhard Wünsch, Guiscard Seebohm
N-methyl-D-aspartate receptors (NMDARs) composed of different splice variants display distinct pH sensitivities and are crucial for learning and memory, as well as for inflammatory or injury processes. Dysregulation of the NMDAR is associated with di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b1517df5e3c09dc46c60046f3e64625
https://doi.org/10.21203/rs.3.rs-2169726/v1
https://doi.org/10.21203/rs.3.rs-2169726/v1