Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christoph Block"'
Autor:
Christian Puller, Elaheh Lotfi, Sabrina Duda, Martin Greschner, Malte T. Ahlers, Christoph Block, Yousef Arzhangnia
Publikováno v:
J Neurosci
Electrical coupling has been reported to occur only between homotypic retinal ganglion cells, in line with the concept of parallel processing in the early visual system. Here, however, we show reciprocal correlated firing between heterotypic ganglion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec09f3fdfe8477ca9b53be32dd30572
https://doi.org/10.1523/jneurosci.1374-19.2019
https://doi.org/10.1523/jneurosci.1374-19.2019
Autor:
Ulrike Janssen-Bienhold, Sebastian Swirski, Konrad Schultz, Martin Greschner, Jasmin Segelken, Karin Dedek, Lea I.S. van der Linde, Christoph Block, Klaus Willecke, Maj Britt Hölzel, Sebastian Ströh, Christian Puller, Hannah Monyer, Reto Weiler
In the mammalian retina, horizontal cells receive glutamatergic inputs from many rod and cone photoreceptors and return feedback signals to them, thereby changing photoreceptor glutamate release in a light-dependent manner. Horizontal cells also prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a875f781d923dbf18d5ab36624fe64aa
https://europepmc.org/articles/PMC6705883/
https://europepmc.org/articles/PMC6705883/
Publikováno v:
ChemBioChem. 3:190-197
By use of the quartz crystal microbalance technique, the interaction of the Raf-Ras binding domain (RafRBD) and the cysteine-rich domain Raf-C1 with lipids was quantified by using solid-supported bilayers immobilized on gold electrodes deposited on 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf8331fe7aa9b92473824291461df00
https://doi.org/10.1002/1439-7633(20020301)3:2/3<190::aid-cbic190>3.0.co
https://doi.org/10.1002/1439-7633(20020301)3:2/3<190::aid-cbic190>3.0.co
Publikováno v:
Oncogene. 19:5367-5376
Mutations of Ras with three extra amino acids inserted into the phosphate-binding (P) loop have been investigated both in vitro and in vivo. Such mutants have originally been detected as oncogenes both in the ras and the TC21 genes. Biochemical exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abeae35340168fff25093eaa17fce7f
https://doi.org/10.1038/sj.onc.1203909
https://doi.org/10.1038/sj.onc.1203909
Autor:
Dirk Graf, Stephan vom Dahl, Christoph Block, Freimut Schliess, Dieter Häussinger, Anna Kordelia Kurz
Publikováno v:
Biochemical Journal. 350:207-213
Ursodesoxycholic acid, widely used for the treatment of cholestatic liver disease, causes choleretic, anti-apoptotic and immunomodulatory effects. Here the effects on choleresis of its taurine conjugate tauroursodesoxycholate (TUDC), which is present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb8f0560c3eba69496f2626839284d3
https://doi.org/10.1042/bj3500207
https://doi.org/10.1042/bj3500207
Autor:
Gudrun Horn, Christian Herrmann, Ralf Janknecht, Christoph Block, Alfred Wittinghofer, Nicolas Nassar
Publikováno v:
Nature Structural & Molecular Biology. 3:723-729
Members of the Ras subfamily of small GTP-binding proteins have been shown to be promiscuous towards a variety of putative effector molecules such as the protein kinase c-Raf and the Ral-specific guanine nucleotide exchange factor (Ral-GEF). To addre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fa06999ab19992e321a1fe9ebb74cb
https://doi.org/10.1038/nsb0896-723
https://doi.org/10.1038/nsb0896-723
Autor:
Christoph Block, Alfred Wittinghofer
Publikováno v:
Structure. 3(12):1281-1284
Could the recent elucidation of the structure of the Rap–Raf complex have been the first glimpse of a universal arrangement between GTPase switches and kinase cascades, as a number of recent reports show that Ras is not unique in its ability to sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa7350577a06201ac8d90a106d8d634
Publikováno v:
Environmental Health Perspectives
Cadmium is a carcinogen whose genotoxicity is only weak. Besides its tumor-initiating capacity, cadmium may be tumor-promoting, since it interferes with several steps of cellular signal transduction. We have investigated effects of cadmium(II) on pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad67b70aff25faf0cd298a2ca14834cc
https://doi.org/10.1289/ehp.94102s3177
https://doi.org/10.1289/ehp.94102s3177
Publikováno v:
Journal of molecular biology. 311(1)
With the completion of the sequences of entire genomes, the need for functional characterisation of proteins and their domains is becoming acute. Conserved regions within proteins often share overlapping functions but despite this conservation may fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da4f4335ff68926fda61f447f32d3e6
https://pubmed.ncbi.nlm.nih.gov/11469853
https://pubmed.ncbi.nlm.nih.gov/11469853
Autor:
Christoph K. Weber, Joseph R. Slupsky, Manuela Schuler, Christoph Block, Ulf R. Rapp, Christian Herrmann
Publikováno v:
Oncogene. 19(2)
In the mitogenic signaling cascade interaction of Ras with Raf represents a critical step for the regulation of cell growth and differentiation. The major effector of Ras, the serine/threonine kinase Raf exists as three isoforms with different tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e81382ead41074e91f261e7e421561
https://pubmed.ncbi.nlm.nih.gov/10644994
https://pubmed.ncbi.nlm.nih.gov/10644994