Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Christoph A Reichel"'
Autor:
Enxian Shi, Zhengquan Wu, Birnur Sinem Karaoglan, Sabina Schwenk-Zieger, Gisela Kranz, Nilofer Abdul Razak, Christoph A. Reichel, Martin Canis, Philipp Baumeister, Reinhard Zeidler, Olivier Gires
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-20 (2023)
Abstract Background Epithelial-to-mesenchymal transition (EMT) of malignant cells is a driving force of disease progression in human papillomavirus-negative (HPV-negative) head and neck squamous cell carcinomas (HNSCC). Sustained hyper-activation of
Externí odkaz:
https://doaj.org/article/a19c6c69db73497296f9698ab827c111
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-19 (2023)
Abstract Background The microvascular endothelium inherently controls nutrient delivery, oxygen supply, and immune surveillance of malignant tumors, thus representing both biological prerequisite and therapeutic vulnerability in cancer. Recently, cel
Externí odkaz:
https://doaj.org/article/67bea446d8134c2a972758860be7ad30
Autor:
Henrik Schinke, Enxian Shi, Zhongyang Lin, Tanja Quadt, Gisela Kranz, Jiefu Zhou, Hongxia Wang, Julia Hess, Steffen Heuer, Claus Belka, Horst Zitzelsberger, Udo Schumacher, Sandra Genduso, Kristoffer Riecken, Yujing Gao, Zhengquan Wu, Christoph A. Reichel, Christoph Walz, Martin Canis, Kristian Unger, Philipp Baumeister, Min Pan, Olivier Gires
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-25 (2022)
Abstract Background Epidermal growth factor receptor (EGFR) is both a driver oncogene and a therapeutic target in advanced head and neck squamous cell carcinoma (HNSCC). However, response to EGFR treatment is inconsistent and lacks markers for treatm
Externí odkaz:
https://doaj.org/article/95531d59b79a463e83a7c5658acca70f
Autor:
Leo Nicolai, Karin Schiefelbein, Silvia Lipsky, Alexander Leunig, Marie Hoffknecht, Kami Pekayvaz, Ben Raude, Charlotte Marx, Andreas Ehrlich, Joachim Pircher, Zhe Zhang, Inas Saleh, Anna-Kristina Marel, Achim Löf, Tobias Petzold, Michael Lorenz, Konstantin Stark, Robert Pick, Gerhild Rosenberger, Ludwig Weckbach, Bernd Uhl, Sheng Xia, Christoph Andreas Reichel, Barbara Walzog, Christian Schulz, Vanessa Zheden, Markus Bender, Rong Li, Steffen Massberg, Florian Gaertner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/ed292487695f4934991736364329901e
Autor:
Bernd Uhl, Florian Haring, Julia Slotta-Huspenina, Joshua Luft, Vera Schneewind, Jonas Hildinger, Zhengquan Wu, Katja Steiger, Bojan Smiljanov, Aarif M. N. Batcha, Oliver T. Keppler, Johannes C. Hellmuth, Tobias Lahmer, Konrad Stock, Bernhard G. Weiss, Martin Canis, Konstantin Stark, Thomas Bromberger, Markus Moser, Christian Schulz, Wilko Weichert, Gabriele Zuchtriegel, Christoph A. Reichel
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Microvascular immunothrombotic dysregulation is a critical process in the pathogenesis of severe systemic inflammatory diseases. The mechanisms controlling immunothrombosis in inflamed microvessels, however, remain poorly understood. Here, we report
Externí odkaz:
https://doaj.org/article/ade407ee878a42518dbdd312efef54f7
Autor:
Tobias F. Primke, Rebecca Ingelfinger, Mohammed A. F. Elewa, Igor Macinkovic, Andreas Weigert, Matthias P. Fabritius, Christoph A. Reichel, Angelika Ullrich, Uli Kazmaier, Luisa D. Burgers, Robert Fürst
Publikováno v:
Cells, Vol 12, Iss 16, p 2112 (2023)
The anti-inflammatory effects of depolymerizing microtubule-targeting agents on leukocytes are known for a long time, but the potential involvement of the vascular endothelium and the underlying mechanistic basis is still largely unclear. Using the r
Externí odkaz:
https://doaj.org/article/0aefd39697be478ca324db28bd49dec4
Autor:
Leo Nicolai, Karin Schiefelbein, Silvia Lipsky, Alexander Leunig, Marie Hoffknecht, Kami Pekayvaz, Ben Raude, Charlotte Marx, Andreas Ehrlich, Joachim Pircher, Zhe Zhang, Inas Saleh, Anna-Kristina Marel, Achim Löf, Tobias Petzold, Michael Lorenz, Konstantin Stark, Robert Pick, Gerhild Rosenberger, Ludwig Weckbach, Bernd Uhl, Sheng Xia, Christoph Andreas Reichel, Barbara Walzog, Christian Schulz, Vanessa Zheden, Markus Bender, Rong Li, Steffen Massberg, Florian Gaertner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Breakdown of vascular barriers is a major complication of inflammatory diseases. However, the mechanisms underlying platelet recruitment to inflammatory micro-environments remains unclear. Here, the authors identify haptotaxis as a key effector funct
Externí odkaz:
https://doaj.org/article/4823a6cec2a1460586e33e31ba7a0aef
Autor:
Luisa D. Burgers, Betty Luong, Yanfen Li, Matthias P. Fabritius, Stylianos Michalakis, Christoph A. Reichel, Rolf Müller, Robert Fürst
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112255- (2021)
Chronic inflammation is characterized by persisting leukocyte infiltration of the affected tissue, which is enabled by activated endothelial cells (ECs). Chronic inflammatory diseases remain a major pharmacotherapeutic challenge, and thus the search
Externí odkaz:
https://doaj.org/article/4d20bc27720141d9918bfdcaca1d4432
Autor:
Thomas Bromberger, Sarah Klapproth, Ina Rohwedder, Jasmin Weber, Robert Pick, Laura Mittmann, Soo Jin Min-Weißenhorn, Christoph A. Reichel, Christoph Scheiermann, Markus Sperandio, Markus Moser
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
β2 integrins mediate key processes during leukocyte trafficking. Upon leukocyte activation, the structurally bent β2 integrins change their conformation towards an extended, intermediate and eventually high affinity conformation, which mediate slow
Externí odkaz:
https://doaj.org/article/c3cea8679646465e990db2cdccfaa565
Autor:
Bernd Uhl, Laura AMittmann, Julian Dominik, Roman Hennel, Bojan Smiljanov, Florian Haring, Johanna BSchaubächer, Constanze Braun, Lena Padovan, Robert Pick, Martin Canis, Christian Schulz, Matthias Mack, Ewgenija Gutjahr, Peter Sinn, Jörg Heil, Katja Steiger, Sandip M Kanse, Wilko Weichert, Markus Sperandio, Kirsten Lauber, Fritz Krombach, Christoph A Reichel
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 6, Pp n/a-n/a (2021)
Abstract High intratumoral levels of urokinase‐type plasminogen activator (uPA)‐plasminogen activator inhibitor‐1 (PAI‐1) heteromers predict impaired survival and treatment response in early breast cancer. The pathogenetic role of this protei
Externí odkaz:
https://doaj.org/article/4c70973c2a744ff8b94cdcdb9b282bf8