Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Christoph A Haselwandter"'
Publikováno v:
eLife, Vol 11 (2022)
Piezo1 is the stretch activated Ca2+ channel in red blood cells that mediates homeostatic volume control. Here, we study the organization of Piezo1 in red blood cells using a combination of super-resolution microscopy techniques and electron microsco
Externí odkaz:
https://doaj.org/article/9c53011f2546426dabb03677f0c1a68f
Publikováno v:
eLife, Vol 7 (2018)
Piezo1 is an ion channel that gates open when mechanical force is applied to a cell membrane, thus allowing cells to detect and respond to mechanical stimulation. Molecular structures of Piezo1 reveal a large ion channel with an unusually curved shap
Externí odkaz:
https://doaj.org/article/4da111984c12418d9f9807684d96f300
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 12, p e1003932 (2014)
In vivo fluorescence microscopy and electron cryo-tomography have revealed that chemoreceptors self-assemble into extended honeycomb lattices of chemoreceptor trimers with a well-defined relative orientation of trimers. The signaling response of the
Externí odkaz:
https://doaj.org/article/e830fd87751644d9b8ee8719d98ec09d
Autor:
Christoph A Haselwandter, Rob Phillips
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 5, p e1003055 (2013)
The mechanosensitive channel of large conductance (MscL) is capable of transducing mechanical stimuli such as membrane tension into an electrochemical response. MscL provides a widely-studied model system for mechanotransduction and, more generally,
Externí odkaz:
https://doaj.org/article/729b595b910f4ad0b70346f60936bbb0
Publikováno v:
Physical Review E. 107
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7452e758c2d72f897edc89a5bdc83358
https://doi.org/10.1103/physreve.107.024409
https://doi.org/10.1103/physreve.107.024409
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Piezo proteins are mechanosensitive ion channels that can locally curve the membrane into a dome shape [Y. R. Guo, R. MacKinnon,eLife6, e33660 (2017)]. The curved shape of the Piezo dome is expected to deform the surrounding lipid bilayer membrane in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f22215675b29bedc03a73f78d737c45
https://doi.org/10.1073/pnas.2208027119
https://doi.org/10.1073/pnas.2208027119
We show in the companion paper that the free membrane shape of lipid bilayer vesicles containing the mechanosensitive ion channel Piezo can be predicted, with no free parameters, from membrane elasticity theory together with measurements of the prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9ed20465bf208e2e506212d6afa939
https://doi.org/10.1101/2022.07.01.498002
https://doi.org/10.1101/2022.07.01.498002
Membrane proteins typically deform the surrounding lipid bilayer membrane, which can play an important role in the function, regulation, and organization of membrane proteins. Membrane elasticity theory provides a beautiful description of protein-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72526e98a2594c90632b25fca3b37d3e
Publikováno v:
Physical review. E. 105(5-1)
Cell membranes are composed of a great variety of protein and lipid species with distinct unperturbed hydrophobic thicknesses. To achieve hydrophobic matching, the lipid bilayer tends to deform around membrane proteins so as to match the protein hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294caf8a52cbf0b7d45530bf54e60d3f
https://pubmed.ncbi.nlm.nih.gov/35706253
https://pubmed.ncbi.nlm.nih.gov/35706253