Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Christoph A, Klein"'
Autor:
Martin Metzenmacher, Balazs Hegedüs, Jan Forster, Alexander Schramm, Peter A. Horn, Christoph A. Klein, Nicola Bielefeld, Till Ploenes, Clemens Aigner, Jens T. Siveke, Martin Schuler, Smiths S. Lueong
Publikováno v:
Thoracic Cancer, Vol 13, Iss 15, Pp 2180-2191 (2022)
Abstract Background CT scans are used in routine clinical practice for the diagnosis and treatment surveillance of non‐small cell lung cancer (NSCLC). However, more sensitive methods are desirable. Liquid biopsy analyses of RNA and DNA can offer mo
Externí odkaz:
https://doaj.org/article/2636748d7c9c455babf6ed2f5ee009ba
Autor:
Maki Asami, Brian Y.H. Lam, Martin Hoffmann, Toru Suzuki, Xin Lu, Naoko Yoshida, Marcella K. Ma, Kara Rainbow, Miodrag Gužvić, Matthew D. VerMilyea, Giles S.H. Yeo, Christoph A. Klein, Anthony C.F. Perry
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112023- (2023)
Summary: At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for development, yet its timing and profile remain elusive i
Externí odkaz:
https://doaj.org/article/58b7a14aaceb4f2b84375d76e14ddecf
Autor:
Sarah M. Hücker, Tobias Fehlmann, Christian Werno, Kathrin Weidele, Florian Lüke, Anke Schlenska-Lange, Christoph A. Klein, Andreas Keller, Stefan Kirsch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Technologies for small non-coding RNA sequencing at the single-cell level are less mature than for sequencing mRNAs. Here the authors evaluate available protocols for analysis of circulating lung cancer tumour cells.
Externí odkaz:
https://doaj.org/article/b7aaf42d26034da3865f132170e16835
Autor:
Melanie Werner-Klein, Ana Grujovic, Christoph Irlbeck, Milan Obradović, Martin Hoffmann, Huiqin Koerkel-Qu, Xin Lu, Steffi Treitschke, Cäcilia Köstler, Catherine Botteron, Kathrin Weidele, Christian Werno, Bernhard Polzer, Stefan Kirsch, Miodrag Gužvić, Jens Warfsmann, Kamran Honarnejad, Zbigniew Czyz, Giancarlo Feliciello, Isabell Blochberger, Sandra Grunewald, Elisabeth Schneider, Gundula Haunschild, Nina Patwary, Severin Guetter, Sandra Huber, Brigitte Rack, Nadia Harbeck, Stefan Buchholz, Petra Rümmele, Norbert Heine, Stefan Rose-John, Christoph A. Klein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Metastatic dissemination in breast cancer patients occurs early in malignant transformation, raising questions about how disseminated cancer cells (DCC) progress at distant sites. Here, the authors show that DCCs in bone marrow are activated via IL6-
Externí odkaz:
https://doaj.org/article/852fb79d2cfa456b923be4f3ce115b15
Autor:
Martin Metzenmacher, Balazs Hegedüs, Jan Forster, Alexander Schramm, Peter A. Horn, Christoph A. Klein, Nicola Bielefeld, Till Ploenes, Clemens Aigner, Dirk Theegarten, Hans-Ulrich Schildhaus, Jens T. Siveke, Martin Schuler, Smiths S. Lueong
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101279- (2022)
Background: Radiology is the current standard for monitoring treatment responses in lung cancer. Limited sensitivity, exposure to ionizing radiations and related sequelae constitute some of its major limitation. Non-invasive and highly sensitive meth
Externí odkaz:
https://doaj.org/article/d3b1076963f443d6a11522f1b04db4d4
Autor:
Liming Tao, Ofir Raz, Zipora Marx, Manjusha S. Ghosh, Sandra Huber, Julia Greindl-Junghans, Tamir Biezuner, Shiran Amir, Lilach Milo, Rivka Adar, Ron Levy, Amos Onn, Noa Chapal-Ilani, Veronika Berman, Asaf Ben Arie, Guy Rom, Barak Oron, Ruth Halaban, Zbigniew T. Czyz, Melanie Werner-Klein, Christoph A. Klein, Ehud Shapiro
Publikováno v:
Cell Reports: Methods, Vol 1, Iss 3, Pp 100054- (2021)
Summary: Cell lineage analysis aims to uncover the developmental history of an organism back to its cell of origin. Recently, novel in vivo methods utilizing genome editing enabled important insights into the cell lineages of animals. In contrast, hu
Externí odkaz:
https://doaj.org/article/ba8554237db044ec9dcf871c12171ac6
Autor:
Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O’Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R. Sprick, Amruta Damle-Vartak, Alexander Hapfelmeier, Norbert Hüser, Ulrike Protzer, Andreas Trumpp, Dieter Saur, Nachiket Vartak, Christoph A. Klein, Bernhard Polzer, Lubor Borsig, Mathias Heikenwalder
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-20 (2018)
Polarisation of metastasising cancer cells in circulation has not been investigated before. Here the authors identify single cell polarity as a distinct polarisation state of single cells in liquid phase, and show that perturbing single cell polarity
Externí odkaz:
https://doaj.org/article/e4d4ca03df544a909e2ed53aef5fd83a
Autor:
Melanie Werner-Klein, Sebastian Scheitler, Martin Hoffmann, Isabelle Hodak, Klaus Dietz, Petra Lehnert, Veronika Naimer, Bernhard Polzer, Steffi Treitschke, Christian Werno, Aleksandra Markiewicz, Kathrin Weidele, Zbigniew Czyz, Ulrich Hohenleutner, Christian Hafner, Sebastian Haferkamp, Mark Berneburg, Petra Rümmele, Anja Ulmer, Christoph A. Klein
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
For several cancer types, mouse models indicate that metastasis occurs early. Here, the authors show that human melanoma cells disseminate early and illustrate a genetic colonisation signature that evolves in parallel at different sites.
Externí odkaz:
https://doaj.org/article/08484ba36c924d67bd84ae818b551c58
Autor:
Felix Elsner, Martin Hoffmann, Rezan Fahrioglu‐Yamaci, Zbigniew Czyz, Giancarlo Feliciello, Tobias Mederer, Bernhard Polzer, Steffi Treitschke, Petra Rümmele, Florian Weber, Hellmuth Wiesinger, Tobias Robold, Zsolt Sziklavari, Wulf Sienel, Hans‐Stefan Hofmann, Christoph A Klein
Publikováno v:
The Journal of Pathology. 258:250-263
In melanoma, immunocytology (IC) after sentinel lymph node disaggregation not only enables better quantification of disseminated cancer cells (DCCs) than routine histopathology (HP) but also provides a unique opportunity to detect, isolate, and analy
Autor:
Franziska C Durst, Ana Grujovic, Iris Ganser, Martin Hoffmann, Peter Ugocsai, Christoph A Klein, Zbigniew T Czyż
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0216442 (2019)
Gene expression analysis of rare or heterogeneous cell populations such as disseminated cancer cells (DCCs) requires a sensitive method allowing reliable analysis of single cells. Therefore, we developed and explored the feasibility of a quantitative
Externí odkaz:
https://doaj.org/article/6e8ba3fa007749bcb8f50752c6b74437