Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Christoph, Wandel"'
Autor:
Celia Goeldner, Priya S. Kishnani, Brian G. Skotko, Julian Lirio Casero, Joerg F. Hipp, Michael Derks, Maria-Clemencia Hernandez, Omar Khwaja, Sian Lennon-Chrimes, Jana Noeldeke, Sabine Pellicer, Lisa Squassante, Jeannie Visootsak, Christoph Wandel, Paulo Fontoura, Xavier Liogier d’Ardhuy, Clematis Study Group
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 14, Iss 1, Pp 1-14 (2022)
Abstract Background There are currently no pharmacological therapies to address the intellectual disability associated with Down syndrome. Excitatory/inhibitory imbalance has been hypothesized to contribute to impairments in cognitive functioning in
Externí odkaz:
https://doaj.org/article/82719940df4e43d5917b4ba65a910b48
Autor:
Erin O’Rourke, Crystal Proud, Craig Zaidman, Perry B. Shieh, Craig McDonald, John W. Day, Stefanie Mason, Maitea Guridi, Lixin Han, Lixi Yu, Carol Reid, Eddie Darton, Christoph Wandel, James Richardson, Jyoti Malhotra, Teji Singh, Louise Rodino-Klapac, Jerry Mendell
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100115- (2023)
Externí odkaz:
https://doaj.org/article/3e80487af3b44c5fac8da0cba332879d
Autor:
Joerg F. Hipp, Frederic Knoflach, Robert Comley, Theresa M. Ballard, Michael Honer, Gerhard Trube, Rodolfo Gasser, Eric Prinssen, Tanya L. Wallace, Andreas Rothfuss, Henner Knust, Sian Lennon-Chrimes, Michael Derks, Darren Bentley, Lisa Squassante, Stephane Nave, Jana Nöldeke, Christoph Wandel, Andrew W. Thomas, Maria-Clemencia Hernandez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract GABAA-α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive dysfunction, as well as other disorders. Here we report on the preclinical and early clinic
Externí odkaz:
https://doaj.org/article/1cc826ca236941e185deaad9d64c993b
Autor:
Crystal Proud, Craig Zaidman, Perry Shieh, Craig McDonald, John Day, Stefanie Mason, Maitea Guridi, Lixin Han, Lixi Yu, Carol Reid, Eddie Darton, Christoph Wandel, James Richardson, Jyoti Malhotra, Tejdip Singh, Louise Rodino-Klapac, Jerry Mendell
Publikováno v:
Thursday, April 27.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5862a1d97622d0da89f4ba24e50c3523
https://doi.org/10.1212/wnl.0000000000203470
https://doi.org/10.1212/wnl.0000000000203470
Autor:
Francesco Muntoni, Eugenio Mercuri, Ulrike Schara Schmidt, Hirofumi Komaki, James Richardson, Tejdip Singh, Maitea Guridi, Stefanie Mason, Alex Murphy, Lixi Yu, Carol Reid, Eddie Darton, Christoph Wandel, Jerry Mendell
Publikováno v:
Monday, April 24.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aabb3e2264ff43cdfdd694f0d140ea1b
https://doi.org/10.1212/wnl.0000000000203455
https://doi.org/10.1212/wnl.0000000000203455
Autor:
Craig Zaidman, Crystal Proud, Craig McDonald, Stefanie Mason, Maitea Guridi, Shufang Wang, Carol Reid, Eddie Darton, Christoph Wandel, Sarah Lewis, Jyoti Malhotra, Danielle Griffin, Rachael Potter, Louise Rodino-Klapac, Jerry Mendell
Publikováno v:
Thursday, April 27.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56a750a48d983e3a398aec8ce6c363de
https://doi.org/10.1212/wnl.0000000000203475
https://doi.org/10.1212/wnl.0000000000203475
Autor:
Suma, Jacob, Jeremy, Veenstra-VanderWeele, Declan, Murphy, James, McCracken, Janice, Smith, Kevin, Sanders, Christoph, Meyenberg, Thomas, Wiese, Gurpreet, Deol-Bhullar, Christoph, Wandel, Elizabeth, Ashford, Evdokia, Anagnostou
Publikováno v:
The Lancet Psychiatry. 9:199-210
There are no approved pharmacological therapies to support treatment of the core communication and socialisation difficulties associated with autism spectrum disorder in adults. We aimed to assess the efficacy, safety, and pharmacokinetics of balovap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373a65dc2819296ad266928f1a472841
https://doi.org/10.1016/s2215-0366(21)00429-6
https://doi.org/10.1016/s2215-0366(21)00429-6
Autor:
Michael Derks, Christoph Wandel, Sian Lennon-Chrimes, Axel Paehler, Piotr Szczesny, Heidemarie Kletzl, Lisa Squassante, Andreas Guenther
Publikováno v:
Expert Opinion on Investigational Drugs. 30:893-901
Balovaptan is a potent, selective vasopressin 1a receptor antagonist. The early-phase pharmacokinetics (PK) of balovaptan are reported.Two Phase 1 studies (overallAbsolute balovaptan bioavailability was high (103-116%). Steady-state (Day 14) balovapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594453fb8d9e29e6cd63b0245011308f
https://doi.org/10.1080/13543784.2021.1948009
https://doi.org/10.1080/13543784.2021.1948009
Autor:
Andreas Rothfuss, Michael Derks, Robert A. Comley, Stephane Nave, Theresa M. Ballard, Sian Lennon-Chrimes, Henner Knust, Christoph Wandel, Joerg F. Hipp, Darren Bentley, Andrew Thomas, Eric Prinssen, Gerhard Trube, Tanya L. Wallace, Jana Nöldeke, Michael Honer, Frédéric Knoflach, Maria-Clemencia Hernandez, Rodolfo Gasser, Lisa Squassante
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Scientific Reports
Scientific Reports
GABAA-α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive dysfunction, as well as other disorders. Here we report on the preclinical and early clinical profil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c3b0913085fae374eb6efde4d99400
https://doaj.org/article/1cc826ca236941e185deaad9d64c993b
https://doaj.org/article/1cc826ca236941e185deaad9d64c993b
Publikováno v:
Advances in Therapy. 37:4720-4729
Balovaptan, an investigational vasopressin 1a receptor antagonist that has been evaluated for improvement of social communication and interaction, is primarily metabolized by cytochrome P450 3A4 (CYP3A4). Two single-center, non-randomized, two-period
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5718d85beaf33db7129a70e9b6bfd8dc
https://doi.org/10.1007/s12325-020-01491-y
https://doi.org/10.1007/s12325-020-01491-y