Zobrazeno 1 - 10
of 365
pro vyhledávání: '"Christoph, Stein"'
Autor:
Ernesto Saenz, Nathally Espinosa Montagut, Baohong Wang, Christoph Stein-Thöringer, Kaicen Wang, Honglei Weng, Matthias Ebert, Kai Markus Schneider, Lanjuan Li, Andreas Teufel
Publikováno v:
Engineering, Vol 40, Iss , Pp 51-60 (2024)
The prevalence of metabolic-dysfunction-associated steatotic liver disease (MASLD) is alarmingly high; it is estimated to affect up to a quarter of the global population, making it the most common liver disorder worldwide. MASLD is characterized by e
Externí odkaz:
https://doaj.org/article/48ba401ac8a94c57be2fe7c5b7225bf8
Publikováno v:
Biophysica, Vol 3, Iss 2, Pp 263-275 (2023)
In our previous studies, a new opioid (NFEPP) was developed to only selectively bind to the μ-opoid receptor (MOR) in inflamed tissue and thus avoid the severe side effects of fentanyl. We know that NFEPP has a reduced binding affinity to MOR in hea
Externí odkaz:
https://doaj.org/article/ead5259faca148e7aab3c0f1eef5a318
Autor:
Arne Thies, Vikram Sunkara, Sourav Ray, Hanna Wulkow, M. Özgür Celik, Fatih Yergöz, Christof Schütte, Christoph Stein, Marcus Weber, Stefanie Winkelmann
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract We previously reported the successful design, synthesis and testing of the prototype opioid painkiller NFEPP that does not elicit adverse side effects. The design process of NFEPP was based on mathematical modelling of extracellular interact
Externí odkaz:
https://doaj.org/article/d41b3150ec0440e0ac1fa50c6b066690
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Opioid agonists are powerful drugs for managing pain. However, their central side effects are limiting their use and drugs with similar potency, but a lower risk profile are needed. (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenylpropio
Externí odkaz:
https://doaj.org/article/330afafbfd49494f949d6c9ad8fad09b
Autor:
Melih Özgür Celik, Viola Seitz, Fatih Yergöz, Sandeep Dembla, Nina Kathleen Blum, Stefan Schulz, Christoph Stein
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide is a newly-designed pain killer selectively activating G-protein-coupled mu-opioid receptors (MOR) in acidic injured tissues, and therefore devoid of central side effects which are typical
Externí odkaz:
https://doaj.org/article/d24edb3270114fefa997af4d5bc07964
Autor:
Antonio Pellegrino, Sandra Mükusch, Viola Seitz, Christoph Stein, Friedrich W. Herberg, Harald Seitz
Publikováno v:
Medical Sciences, Vol 10, Iss 4, p 63 (2022)
The sensory ion channel transient receptor potential vanilloid 1 (TRPV1) is mainly expressed in small to medium sized dorsal root ganglion neurons, which are involved in the transfer of acute noxious thermal and chemical stimuli. The Ankyrin-rich mem
Externí odkaz:
https://doaj.org/article/d1350019d9ae443eb9975b4fd90a1a70
Autor:
Mira Woitok, Elena Grieger, Olusiji A Akinrinmade, Susanne Bethke, Anh Tuan Pham, Christoph Stein, Rolf Fendel, Rainer Fischer, Stefan Barth, Judith Niesen
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243286 (2020)
In vitro and ex vivo development of novel therapeutic agents requires reliable and accurate analyses of the cell conditions they were preclinical tested for, such as apoptosis. The detection of apoptotic cells by annexin V (AV) coupled to fluorophore
Externí odkaz:
https://doaj.org/article/c05b4978132b4524b68c1177dd13fb04
Autor:
Sabrina Berens, Yuanjun Dong, Nikola Fritz, Jutta Walstab, Mauro D'Amato, Tenghao Zheng, Verena Wahl, Felix Boekstegers, Justo Lorenzo Bermejo, Cristina Martinez, Stefanie Schmitteckert, Egbert Clevers, Felicitas Engel, Annika Gauss, Wolfgang Herzog, Robin Spiller, Miriam Goebel-Stengel, Hubert Mönnikes, Viola Andresen, Frieling Thomas, Jutta Keller, Christian Pehl, Christoph Stein-Thöringer, Gerard Clarke, Timothy G Dinan, Eamonn M Quigley, Gregory Sayuk, Magnus Simrén, Jonas Tesarz, Gudrun Rappold, Lukas van Oudenhove, Rainer Schaefert, Beate Niesler
Publikováno v:
World Journal of Gastroenterology. 28:2334-2349
BACKGROUND: Single-nucleotide polymorphisms (SNPs) of the serotonin type 3 receptor subunit (HTR3) genes have been associated with psychosomatic symptoms, but it is not clear whether these associations exist in irritable bowel syndrome (IBS). AIM: To
Autor:
Sourav Ray, Christof Schütte, Fatih Yergoz, Christoph Stein, Stefanie Winkelmann, Özgür Celik, Marcus Weber, Arne Thies, Vikram Sunkara
Publikováno v:
Scientific Reports. 13
Initiated by mathematical modelling of extracellular interactions between G-protein coupled receptors (GPCRs) and ligands in normal versus diseased (inflamed) environments, we previously reported the successful design, synthesis and testing of the pr