Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Christoph, Schmal"'
Autor:
Carolin Ector, Christoph Schmal, Jeff Didier, Sébastien De Landtsheer, Anna-Marie Finger, Francesca Müller-Marquardt, Johannes H. Schulte, Thomas Sauter, Ulrich Keilholz, Hanspeter Herzel, Achim Kramer, Adrián E. Granada
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administrati
Externí odkaz:
https://doaj.org/article/7f9b4ff997de4ecbb614a0fa51da477c
Autor:
Hanspeter Herzel, Christian Gabriel, Achim Kramer, Camillo Mizaikoff, Saskia Grabe, Marta del Olmo, Christoph Schmal
Publikováno v:
F1000Research, Vol 12 (2024)
Three parameters are important to characterize a circadian and in general any biological clock: period, phase and amplitude. While circadian periods have been shown to correlate with entrainment phases, and clock amplitude influences the phase respon
Externí odkaz:
https://doaj.org/article/79c465508fca450aa06e09d2444f161b
Publikováno v:
Heliyon, Vol 10, Iss 2, Pp e24773- (2024)
Circadian clocks are endogenous oscillators present in almost all cells that drive daily rhythms in physiology and behavior. There are two mechanisms that have been proposed to explain how circadian rhythms are generated in mammalian cells: through a
Externí odkaz:
https://doaj.org/article/7d8ad7d68c1b446f8601106d309ce567
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The synchronization of multiple oscillators serves as the central mechanism for maintaining stable circadian rhythms in physiology and behavior. Aging and disease can disrupt synchronization, leading to changes in the periodicity of circadian activit
Externí odkaz:
https://doaj.org/article/c816f6b9619743ea954e1dc73b2563d8
Autor:
Hanspeter Herzel, Christian Gabriel, Achim Kramer, Camillo Mizaikoff, Saskia Grabe, Marta del Olmo, Christoph Schmal
Publikováno v:
F1000Research, Vol 12 (2023)
Three parameters are important to characterize a circadian and in general any biological clock: period, phase and amplitude. While circadian periods have been shown to correlate with entrainment phases, and clock amplitude influences the phase respon
Externí odkaz:
https://doaj.org/article/2fe029b58809407e89dabb15c86fa9ad
Autor:
Daisuke Ono, Ken-ichi Honma, Christoph Schmal, Toru Takumi, Takeshi Kawamoto, Katsumi Fujimoto, Yukio Kato, Sato Honma
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Clock genes Cry1 and Cry2, inhibitory components of core molecular feedback loop, are regarded as critical molecules for the circadian rhythm generation in mammals. A double knockout of Cry1 and Cry2 abolishes the circadian behavioral rhythm
Externí odkaz:
https://doaj.org/article/2264fe39e11443cc9f953c3785c8c006
Autor:
Philipp Burt, Saskia Grabe, Cornelia Madeti, Abhishek Upadhyay, Martha Merrow, Till Roenneberg, Hanspeter Herzel, Christoph Schmal
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103370- (2021)
Summary: Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for ligh
Externí odkaz:
https://doaj.org/article/c86cdd7fecb0449e9b4cd82d3a3dd946
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Entrainment denotes a process of coordinating the internal circadian clock to external rhythmic time-cues (Zeitgeber), mainly light. It is facilitated by stronger Zeitgeber signals and smaller period differences between the internal clock and the ext
Externí odkaz:
https://doaj.org/article/9a6e5af61bf94499805b04cdc56dde29
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Understanding entrainment of circadian rhythms is a central goal of chronobiology. Many factors, such as period, amplitude, Zeitgeber strength, and daylength, govern entrainment ranges and phases of entrainment. We have tested whether simple amplitud
Externí odkaz:
https://doaj.org/article/433863811b684a15aeaf5d4809580523
Autor:
Jihwan Myung, Christoph Schmal, Sungho Hong, Yoshiaki Tsukizawa, Pia Rose, Yong Zhang, Michael J. Holtzman, Erik De Schutter, Hanspeter Herzel, Grigory Bordyugov, Toru Takumi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The suprachiasmatic nucleus (SCN) has been thought of as the master circadian clock, but peripheral circadian clocks do exist. Here, the authors show that the choroid plexus displays oscillations more robust than the SCN and that can be described as
Externí odkaz:
https://doaj.org/article/707c2f42059b4009a9d4a81449745eaf