Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Christoph, Loenarz"'
Autor:
Lukas Gericke, Dipali Mhaindarkar, Lukas C. Karst, Sören Jahn, Marco Kuge, Michael K. F. Mohr, Jana Gagsteiger, Nicolas V. Cornelissen, Xiaojin Wen, Silja Mordhorst, Henning J. Jessen, Andrea Rentmeister, Florian P. Seebeck, Gunhild Layer, Christoph Loenarz, Jennifer N. Andexer
Publikováno v:
ChemBioChem. 24
Autor:
Verena B. Eisenbeis, Danye Qiu, Lisa Strotmann, Guizhen Liu, Isabel Prucker, Kevin Ritter, Christoph Loenarz, Adolfo Saiardi, Henning J. Jessen
1AbstractInositol pyrophosphates (PP-InsPs) are energetic signalling molecules with important functions in mammals. As their biosynthesis depends on ATP concentration, PP-InsPs are tightly connected to cellular energy homeostasis. Consequently, an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65bf789a6cef6396d4efa09b21383c75
https://doi.org/10.1101/2022.11.27.518098
https://doi.org/10.1101/2022.11.27.518098
Autor:
Lukas Gericke, Dipali Mhaindarkar, Lukas Karst, Sören Jahn, Marco Kuge, Michael K. F. Mohr, Jana Gagsteiger, Nicolas V. Cornelissen, Xiaojin Wen, Silja Mordhorst, Henning J. Jessen, Andrea Rentmeister, Florian P. Seebeck, Gunhild Layer, Christoph Loenarz, Jennifer N. Andexer
S-Adenosylmethionine (SAM) is an enzyme cofactor involved in methylation, aminopropyl transfer, and radical reactions. This versatility renders SAM-dependent enzymes of great interest in biocatalysis. The usage of SAM analogues adds to this diversity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08fe24e923b40be13a74349ce540daf4
https://doi.org/10.1101/2022.09.26.509380
https://doi.org/10.1101/2022.09.26.509380
Autor:
Jana Gagsteiger, Sören Jahn, Lorenz Heidinger, Lukas Gericke, Jennifer N. Andexer, Thorsten Friedrich, Christoph Loenarz, Gunhild Layer
Publikováno v:
Angew. Chem. Int. Ed.
Autor:
Christoph Loenarz
Publikováno v:
Angewandte Chemie International Edition. 59:3776-3780
The 2019 Nobel Prize in Physiology or Medicine honours three scientists that devoted their careers to pursuing an audacious basic science question: by what mechanisms do animals sense oxygen, and how can cells adapt to a lack of oxygen? The identific
Autor:
Christoph Loenarz
Publikováno v:
Angewandte Chemie. 132:3804-3809
Autor:
Emily Flashman, Christoph Loenarz, Martin Münzel, Sarah E. Wilkins, Michael A. McDonough, Rok Sekirnik, Hanna Tarhonskaya, Christopher J. Schofield, Aayan Hussein, Shabaz Mohammed, Jacob T. Bush
Publikováno v:
Extremophiles
YcfD from Escherichia coli is a homologue of the human ribosomal oxygenases NO66 and MINA53, which catalyse histidyl-hydroxylation of the 60S subunit and affect cellular proliferation (Ge et al., Nat Chem Biol 12:960–962, 2012). Bioinformatic analy
Autor:
Armin Thalhammer, Zuzana Bencokova, Rachel Poole, Christoph Loenarz, Julie Adam, Linda O'Flaherty, Johannes Schödel, David Mole, Konstantinos Giaslakiotis, Christopher J Schofield, Ester M Hammond, Peter J Ratcliffe, Patrick J Pollard
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16210 (2011)
Human 2-oxoglutarate oxygenases catalyse a range of biological oxidations including the demethylation of histone and nucleic acid substrates and the hydroxylation of proteins and small molecules. Some of these processes are centrally involved in regu
Externí odkaz:
https://doaj.org/article/d8b08645bf7840749a1fcc8057e57e37
Autor:
Christoph Loenarz, Martine I. Abboud, Rasheduzzaman Chowdhury, Kerstin Lippl, Ivanhoe K. H. Leung, Christopher J. Schofield, Timothy D. W. Claridge
Publikováno v:
Chembiochem. 19(21)
In animals, the response to chronic hypoxia is mediated by upregulation of the α,β-heterodimeric hypoxia-inducible factors (HIFs). Levels of HIFα isoforms, but not HIFβ, are regulated by their post-translational modification as catalysed by proly
Autor:
Christopher D.O. Cooper, Peter J. Ratcliffe, Christoph Loenarz, Wei Ge, Nathan R. Rose, Christopher J. Schofield, Robert J. Klose, Mathew L. Coleman
Mutations of human PHF8 cluster within its JmjC encoding exons and are linked to mental retardation (MR) and a cleft lip/palate phenotype. Sequence comparisons, employing structural insights, suggest that PHF8 contains the double stranded beta-helix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9c4a86a248a6b768b394dea1bcd7a8
https://doi.org/10.1093/hmg/ddp480
https://doi.org/10.1093/hmg/ddp480