Výsledky vyhledávání - "Christoph, Korbmacher"

Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels

Autor: Simona E. Carbone, Stephen J. Keely, Andreacarola Urso, Daniel P. Poole, Christoph Korbmacher, Alexandr V. Ilyaskin, Nigel W. Bunnett

Publikováno v: Am J Physiol Gastrointest Liver Physiol

Bile acids (BAs) are known to be important regulators of intestinal motility and epithelial fluid and electrolyte transport. Over the past two decades, significant advances in identifying and characterizing the receptors, transporters, and ion channe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40a183749b54aa29b895cd18516e775
https://pubmed.ncbi.nlm.nih.gov/34755536

Zobrazit plný text záznamu

Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel’s γ-subunit

Autor: Florian Sure, Marko Bertog, Sara Afonso, Alexei Diakov, Ralf Rinke, M. Gregor Madej, Sabine Wittmann, Thomas Gramberg, Christoph Korbmacher, Alexandr V. Ilyaskin

The epithelial sodium channel (ENaC) is a heterotrimer consisting of α-, β-, and γ-subunits. Channel activation requires proteolytic release of inhibitory tracts from the extracellular domains of α-ENaC and γ-ENaC; however, the proteases involve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1647ad897ede0e49595e59a2dbc68df
https://epub.uni-regensburg.de/52234/

Zobrazit plný text záznamu

Two adjacent phosphorylation sites in the C-terminus of the channel's α-subunit have opposing effects on epithelial sodium channel (ENaC) activity

Autor: Alexei Diakov, Viatcheslav Nesterov, Anke Dahlmann, Christoph Korbmacher

Publikováno v: Pflugers Archiv : European journal of physiology. 474(7)

How phosphorylation of the epithelial sodium channel (ENaC) contributes to its regulation is incompletely understood. Previously, we demonstrated that in outside-out patches ENaC activation by serum- and glucocorticoid-inducible kinase isoform 1 (SGK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d663fffef508e4920d81040b71545f
https://pubmed.ncbi.nlm.nih.gov/35676334

Zobrazit plný text záznamu

Effects of syntaxins 2, 3, and 4 on rat and human epithelial sodium channel (ENaC) in Xenopus laevis oocytes

Autor: Christoph Korbmacher, Robert Rauh, Fabian Frost

Publikováno v: Pflugers Archiv

Syntaxins are SNARE proteins and may play a role in epithelial sodium channel (ENaC) trafficking. The aim of the present study was to investigate the effects of syntaxin 2 (STX2), syntaxin 3 (STX3), and syntaxin 4 (STX4) on rat (rENaC) and human ENaC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e3d7072d75dbca7254af10b275cb48
https://doi.org/10.1007/s00424-020-02365-6

Zobrazit plný text záznamu

High baseline ROMK activity in the mouse late distal convoluted and early connecting tubule probably contributes to aldosterone-independent K

Autor: Viatcheslav Nesterov, Marko Bertog, Christoph Korbmacher

Publikováno v: American journal of physiology. Renal physiology. 322(1)

The renal outer medullary K+ channel (ROMK) is co-localized with the epithelial Na+ channel (ENaC) in late distal convoluted tubule (DCT2), connecting tubule (CNT) and cortical collecting duct (CCD). ENaC-mediated Na+ absorption generates the electri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1936d212ed224b07ae0e55d20f0a46b6
https://pubmed.ncbi.nlm.nih.gov/34843658

Zobrazit plný text záznamu

A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts

Publikováno v: Journal of Cell Science
article-version (VoR) Version of Record

Mutations in the PKD2 gene cause autosomal-dominant polycystic kidney disease but the physiological role of polycystin-2, the protein product of PKD2, remains elusive. Polycystin-2 belongs to the transient receptor potential (TRP) family of non-selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4fd48c1c766e87d3fe6f1f0fe1a9ce
http://europepmc.org/articles/PMC8435292

Zobrazit plný text záznamu

Critical role of the mineralocorticoid receptor in aldosterone-dependent and aldosterone-independent regulation of ENaC in the distal nephron

Autor: Jérémie Canonica, Paul A. Welling, Christoph Korbmacher, Edith Hummler, Viatcheslav Nesterov, Marko Bertog, Richard Coleman

Publikováno v: Am J Physiol Renal Physiol

The epithelial Na(+) channel (ENaC) constitutes the rate-limiting step for Na(+) absorption in the aldosterone-sensitive distal nephron (ASDN) comprising the late distal convoluted tubule (DCT2), connecting tubule (CNT), and collecting duct (CD). Pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5d8ce99393b40d6b4890c67c84028a
https://europepmc.org/articles/PMC9847332/

Zobrazit plný text záznamu

Bile acids inhibit human purinergic receptor P2X4 in a heterologous expression system

Autor: Silke Haerteis, Christoph Korbmacher, Viatcheslav Nesterov, Alexandr V. Ilyaskin, Florian Sure

Publikováno v: The Journal of General Physiology

The human purinergic receptor P2X4 is an ATP-gated nonselective cation channel expressed in a variety of cells, including hepatocytes and cholangiocytes. Ilyaskin et al. find that the bile acids inhibit P2X4 by stabilizing the channel's closed state,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2e9f076bb662339288ba0d0b01edb0
http://europepmc.org/articles/PMC6572003

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání