Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Christoph, Koentges"'
Autor:
Mark E. Pepin, Christoph Koentges, Katharina Pfeil, Johannes Gollmer, Sophia Kersting, Sebastian Wiese, Michael M. Hoffmann, Katja E. Odening, Constantin von zur Mühlen, Philipp Diehl, Peter Stachon, Dennis Wolf, Adam R. Wende, Christoph Bode, Andreas Zirlik, Heiko Bugger
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Decreased serum adiponectin levels in type 2 diabetes has been linked to the onset of mitochondrial dysfunction in diabetic complications by impairing AMPK-SIRT1-PGC-1α signaling via impaired adiponectin receptor 1 (AdipoR1) signaling. Here, we aime
Externí odkaz:
https://doaj.org/article/d0270a67460e4aefab542488ea2e765b
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 3 (2016)
Functional defects in mitochondrial biology causally contribute to various human diseases, including cardiovascular disease. Impairment in oxidative phosphorylation, mitochondrial oxidative stress and increased opening of the mitochondrial permeabili
Externí odkaz:
https://doaj.org/article/2c5d184c177740b595705022fdba18be
Autor:
Nikole J. Byrne, Constantin N. Witt, Christoph Koentges, Katharina Pfeil, Thomas Pusdrowski, Johannes Gollmer, Ivan Vosko, Christoph Bode, Andreas Zirlik, Heiko Bugger
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::953064ce1b0b4b62a7a98c2fa34f61d2
https://doi.org/10.1016/j.yjmcc.2022.08.135
https://doi.org/10.1016/j.yjmcc.2022.08.135
Autor:
Franziska Pankratz, Oliver Gorka, Philipp Diehl, Delia Schlösser, Olaf Groß, Aleksandre Tarkhnishvili, Dietmar Pfeifer, Heiko Bugger, Xavier Bemtgen, Christian Smolka, Christoph Koentges, Sebastian Grundmann, Martin Moser, Alexander Asmussen, Christoph Bode
Publikováno v:
The FASEB Journal. 35
MicroRNAs are key regulators of the cardiac response to injury. MiR-100 has recently been suggested to be involved in different forms of heart failure, but functional studies are lacking. In the present study, we examined the impact of transgenic miR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28179059e672fcb03f6254704785c95a
https://doi.org/10.1096/fj.202100829rr
https://doi.org/10.1096/fj.202100829rr
Autor:
Martin Braun, Niko Hettinger, Christoph Koentges, Katharina Pfeil, Maria C Cimolai, Michael M Hoffmann, Moritz Osterholt, Torsten Doenst, Christoph Bode, Heiko Bugger
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119416 (2015)
Adiponectin deficiency leads to increased myocardial infarct size following ischemia reperfusion and to exaggerated cardiac hypertrophy following pressure overload, entities that are causally linked to mitochondrial dysfunction. In skeletal muscle, l
Externí odkaz:
https://doaj.org/article/1fa183b82a0e46ed9b2d41a20cee6ad2
Autor:
Aleksandre, Tarkhnishvili, Christoph, Koentges, Katharina, Pfeil, Johannes, Gollmer, Nikole J, Byrne, Ivan, Vosko, Julia, Lueg, Laura, Vogelbacher, Stephan, Birkle, Sibai, Tang, Timothy, Bon-Nawul Mwinyella, Michael M, Hoffmann, Katja E, Odening, Nathaly Anto, Michel, Dennis, Wolf, Peter, Stachon, Ingo, Hilgendorf, Markus, Wallner, Senka, Ljubojevic-Holzer, Dirk, von Lewinski, Peter, Rainer, Simon, Sedej, Harald, Sourij, Christoph, Bode, Andreas, Zirlik, Heiko, Bugger
Publikováno v:
Journal of lipid and atherosclerosis. 11(2)
Impaired cardiac efficiency is a hallmark of diabetic cardiomyopathy in models of type 2 diabetes. Adiponectin receptor 1 (AdipoR1) deficiency impairs cardiac efficiency in non-diabetic mice, suggesting that hypoadiponectinemia in type 2 diabetes may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4fda0e17466bd3787910f4a5bda5b40
https://pubmed.ncbi.nlm.nih.gov/35656151
https://pubmed.ncbi.nlm.nih.gov/35656151
Autor:
Maria C. Cimolai, Philipp Diehl, Aleksandre Tarkhnishvili, Heiko Bugger, Michael M. Hoffmann, Katja E. Odening, Constantin von zur Mühlen, Andreas Zirlik, Christoph Koentges, Katharina Pfeil, Christoph Bode, Dennis Wolf, Silvia Alvarez, Timoteo Marchini
Publikováno v:
Journal of Molecular and Cellular Cardiology. 133:138-147
Background Sepsis-induced cardiomyopathy contributes to the high mortality of septic shock in critically ill patients. Since the underlying mechanisms are incompletely understood, we hypothesized that sepsis-induced impairment of sirtuin 3 (SIRT3) ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd85504c47f96338cd08c658a3da232
https://doi.org/10.1016/j.yjmcc.2019.06.008
https://doi.org/10.1016/j.yjmcc.2019.06.008
Autor:
C N Witt, L Vogelbacher, C. Bode, Andreas Zirlik, Heiko Bugger, Katharina Pfeil, Christoph Koentges, T Pusdrowski
Publikováno v:
European Heart Journal. 40
Sirtuin 5 (SIRT5) is a mitochondrial NAD+-dependent protein deacylase which regulates the enzymatic activity of numerous mitochondrial proteins due to increased succinylation and malonylation, including enzymes of energy substrate oxidation and mitoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c61ca35a82889a6b970284f1ced5a65
https://doi.org/10.1093/eurheartj/ehz746.0341
https://doi.org/10.1093/eurheartj/ehz746.0341
Autor:
C. Bode, Katharina Pfeil, Mark E Pepin, Andreas Zirlik, Adam R. Wende, Christoph Koentges, Heiko Bugger, Johannes Gollmer
Publikováno v:
European Heart Journal. 40
Lack of the adiponectin target receptor adiponectin receptor 1 (AdipoR1) impairs gene expression of mitochondrial OXPHOS proteins due to impaired AMPK-SIRT1-PGC-1α signaling. Since decreased adiponectin serum levels in diabetes mellitus should thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a4696cb7a89edf92680c9b9bebfdc7c
https://doi.org/10.1093/eurheartj/ehz745.0350
https://doi.org/10.1093/eurheartj/ehz745.0350
Autor:
Eva A. Rog-Zielinska, Natalie Hoppe, Christoph Koentges, I Ahmed, Peter Kohl, Heiko Bugger, Andreas Zirlik, Peter Stachon, K Rofa, D Dimanski, Bianca Dufner, J Merz, C. Bode, Ingo Hilgendorf
Publikováno v:
European Heart Journal. 40
Introduction Cardiomyopathies due to pathological remodelling are the most common myocardial disorders and leading indication for heart transplant in young adults. Cardiomyocytes rely on sessile macrophage phagocytosis for cell homeostasis. Purinergi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baaa44c6eafc2ceee7b77a92f11b3e51
https://doi.org/10.1093/eurheartj/ehz746.0942
https://doi.org/10.1093/eurheartj/ehz746.0942