Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Christoph, Kündig"'
Autor:
Loyse M. Felber, Sylvain M. Cloutier, Christoph Kündig, Tadaaki Kishi, Vincent Brossard, Patrice Jichlinski, Hans-Jürg Leisinger, David Deperthes
Publikováno v:
BioTechniques, Vol 36, Iss 5, Pp 878-885 (2004)
A protease can be defined as an enzyme capable of hydrolyzing peptide bonds. Thus, characterization of a protease involves identification of target peptide sequences, measurement of activities toward these sequences, and determination of kinetic para
Externí odkaz:
https://doaj.org/article/b9d6ef8b4207428a9bd9285dfb49ecda
Autor:
Cloutier Sylvain, David Deperthes, Omar M. Fattah, Hans-Jürg Leisinger, Eric R. Gauthier, Christoph Kündig, Christian M. Gygi, Loyse M. Felber, Jean-Pierre Mach, Patrice Jichlinski
Publikováno v:
International Journal of Cancer. 119:2455-2463
The epidermal growth factor receptor (EGFR) plays a central role in cell life by controlling processes such as growth or proliferation. This receptor is commonly overexpressed in a number of epithelial malignancies and its upregulation is often assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f4d2289ee328ca4af94ad57aa591d5
https://doi.org/10.1002/ijc.21541
https://doi.org/10.1002/ijc.21541
Autor:
Loyse M. Felber, Hans-Jürg Leisinger, Carla A. Borgoño, Christian M. Gygi, Jair R. Chagas, Eleftherios P. Diamandis, Patrice Jichlinski, Cloutier Sylvain, Christoph Kündig, David Deperthes, A. Tasinato
Publikováno v:
FEBS Journal. 273:2505-2514
The reactive center loop (RCL) of serpins plays an essential role in the inhibition mechanism acting as a substrate for their target proteases. Changes within the RCL sequence modulate the specificity and reactivity of the serpin molecule. Recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fc520bf1800ef8d492a33167cb19ddd
https://doi.org/10.1111/j.1742-4658.2006.05257.x
https://doi.org/10.1111/j.1742-4658.2006.05257.x
Publikováno v:
Journal of Biological Chemistry. 279:18575-18582
The protozoan parasite Leishmania is a folate and pterin auxotroph. The main biopterin transporter (BT1) and pterin reductase (PTR1) have already been characterized in Leishmania. In this study, we have succeeded in generating a BT1 and PTR1 null mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c99769d359aa5a2726cefbc05e2daa
https://doi.org/10.1074/jbc.m400652200
https://doi.org/10.1074/jbc.m400652200
Autor:
Jair R. Chagas, Christian M. Gygi, Christoph Kündig, Omar M. Fattah, Hans-Jürg Leisinger, David Deperthes, Cloutier Sylvain, Loyse M. Felber, Patrice Jichlinski
Publikováno v:
European Journal of Biochemistry. 271:607-613
The reactive site loop of serpins undoubtedly defines in part their ability to inhibit a particular enzyme. Exchanges in the reactive loop of serpins might reassign the targets and modify the serpin-protease interaction kinetics. Based on this concep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37136b949dbd1c7d80c95a860dddfbaf
https://doi.org/10.1111/j.1432-1033.2003.03963.x
https://doi.org/10.1111/j.1432-1033.2003.03963.x
Autor:
Hans-Jürg Leisinger, Cloutier Sylvain, Christian M. Gygi, Patrice Jichlinski, Christoph Kündig, David Deperthes
Publikováno v:
Tumor Biology. 25:24-30
Although the cellular steps required for metastasis are similar for all cancer cells, proteases involved in this process and their expression levels vary greatly between different cancer types. Thus, the identification of these proteolytic activities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fe30021ebecb9cb9550c7d6fd29188
https://doi.org/10.1159/000077720
https://doi.org/10.1159/000077720
Publikováno v:
ResearcherID
Folates are polyglutamylated in most organisms, and in cancer cells the polyglutamylation of folates and of the antifolate methotrexate (MTX) is an important determinant of MTX susceptibility. The folylpolyglutamate synthetase (FPGS) responsible for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637edb23112975c1691fa855828d27fb
https://doi.org/10.1016/s0006-2952(03)00417-9
https://doi.org/10.1016/s0006-2952(03)00417-9
Publikováno v:
Experimental Parasitology. 97:161-168
Roy, G., Kundig, C., Olivier, M., Papadopoulou, B., and Ouellette, M. 2001. Adaptation of Leishmania cells to in vitro culture results in a more efficient reduction and transport of biopterin. Experimental Parasitology97, 161–168. Leishmania major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5800740c4d3c744882b0fcdb238f49f4
https://doi.org/10.1006/expr.2001.4595
https://doi.org/10.1006/expr.2001.4595
Autor:
Roger Marty, Christoph Kündig, Christoph Beck, Hauke Hennecke, Michael Göttfert, Sandra Röthlisberger
Publikováno v:
Journal of Bacteriology. 183:1405-1412
The physical and genetic map of the Bradyrhizobium japonicum chromosome revealed that nitrogen fixation and nodulation genes are clustered. Because of the complex interactions between the bacterium and the plant, we expected this chromosomal sector t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453a3ffe08efb246d7155c9391c0f417
https://doi.org/10.1128/jb.183.4.1405-1412.2001
https://doi.org/10.1128/jb.183.4.1405-1412.2001
Publikováno v:
ResearcherID
The protozoan parasite Leishmania resists the antifolate methotrexate (MTX) by amplifying the R locus dihydrofolate reductase-thymidylate synthase ( dhfr-ts ) gene, the H locus ptr1 pterin reductase gene, and finally by mutation in a common folate/MT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7497840e8cce882c85f8178bb34662df
https://doi.org/10.1093/nar/27.18.3653
https://doi.org/10.1093/nar/27.18.3653