Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Christoph, Falschlunger"'
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Akademický článek
Syntheses and crystal structures of [IrIII{C(CHCO2Et)(dppm)2-κ4P,C,C′,P′}ClH]Cl·2.75CH2Cl2 and its derivatives, [IrIII{C(CHCO2Et)(dppm)2-κ4P,C,C′,P′}(CH2CO2Et)Cl]Cl·CH3OH·0.5H2O, [IrIII{C(CHCO2Et)(dppm)2-κ4P,C,C′,P′}Cl2]Cl·CH3OH·2H2O and [IrIII{C(CHCO2Et)(dppm)2-κ4P,C,C′,P′}(CH2CO2Et)(CO)]Cl2·2CH2Cl2·1.5H2O
Autor: Inge Schlapp-Hackl, Christoph Falschlunger, Kathrin Zauner, Walter Schuh, Holger Kopacka, Klaus Wurst, Paul Peringer
Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 1, Pp 12-20 (2019)
The common feature of the four iridium(III) salt complexes, (bis{[(diphenylphosphanyl)methyl]diphenylphosphanylidene}(ethoxyoxoethanylidene)methane-κ4P,C,C′,P′)chloridohydridoiridium(III) chloride methylene chloride 2.75-solvate (4), (bis{[(diph
Externí odkaz: https://doaj.org/article/c9788750fef44069ba8879b63f2e5577
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2
Akademický článek
Crystal structures of the [IrIII{C(C4H6O2)(dppm)-κ3P,C,O}(dppm)H](CF3O3S)2 and [IrIII{C(C4H6O2)(dppm)-κ2P,C}(CO)(dppm)H](CF3O3S)2 phosphorus ylide complexes, generated by a Wittig-type carbon–carbon coupling reaction of a carbodiphosphorane PCP ligand system
Autor: Inge Schlapp-Hackl, Bettina Pauer, Christoph Falschlunger, Walter Schuh, Holger Kopacka, Klaus Wurst, Paul Peringer
Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 74, Iss 11, Pp 1643-1647 (2018)
The reaction of [IrIII{C(dppm)2-κ3P,C,P′}ClH(NH3C2)]Cl with ethyl diazoacetate, a well known C=C coupling reagent, leads to the formation of a C=C unit, accompanied by N2 abstraction, reorganization of a dppm subunit and, considered as a whole, to
Externí odkaz: https://doaj.org/article/49773ebf8ebe40fa830d78a109e2015a
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4
Structural insights into synthetic ligands targeting A–A pairs in disease-related CAG RNA repeats
Autor: Agnieszka Kiliszek, Sanjukta Mukherjee, Asako Murata, Wojciech Rypniewski, Chikara Dohno, Ronald Micura, Kazuhiko Nakatani, Christoph Falschlunger, Leszek Błaszczyk
Publikováno v: Nucleic acids symposium series 47(20), 10906-10913 (2019). doi:10.1093/nar/gkz832
Nucleic Acids Research
The trinucleotide repeat expansion disorders (TREDs) constitute of a group of >40 hereditary neurodegenerative human diseases associated with abnormal expansion of repeated sequences, such as CAG repeats. The pathogenic factor is a transcribed RNA or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b1ba4c57c189d392a4b1aaad90de98
https://doi.org/10.1093/nar/gkz832
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7
Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes
Autor: Thomas Kemmer, Christoph Falschlunger, Guillaume Bec, Virginie Marchand, Ronald Micura, Claudia Höbartner, Yuri Motorin, Mark Helm, Lukas Schmidt, Maksim V. Sednev, Stephan Werner, Eric Ennifar, Andreas Hildebrandt
Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48 (7), pp.3734-3746. ⟨10.1093/nar/gkaa113⟩
Nucleic Acids Research, 2020, 48 (7), pp.3734-3746. ⟨10.1093/nar/gkaa113⟩
Reverse transcription (RT) of RNA templates containing RNA modifications leads to synthesis of cDNA containing information on the modification in the form of misincorporation, arrest, or nucleotide skipping events. A compilation of such events from m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2eb5ba21a71b0fb7581e982861c088
https://hal.univ-lorraine.fr/hal-02492494
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8
Atom-Specific Mutagenesis Reveals Structural and Catalytic Roles for an Active-Site Adenosine and Hydrated Mg2+ in Pistol Ribozymes
Autor: Dinshaw J. Patel, Ronald Micura, Aiming Ren, Elisabeth Fuchs, Sandro Neuner, Maximilian Himmelstoss, Christoph Falschlunger
Publikováno v: Angewandte Chemie International Edition. 56:15954-15958
The pistol RNA motif represents a new class of self-cleaving ribozymes of yet unknown biological function. Our recent crystal structure of a pre-catalytic state of this RNA shows guanosine G40 and adenosine A32 close to the G53–U54 cleavage site. W
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bba7964a60fc631a52d51a9b677205
https://doi.org/10.1002/anie.201708679
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9
The effect of adenine protonation on RNA phosphodiester backbone bond cleavage elucidated by deaza-nucleobase modifications and mass spectrometry
Autor: Kathrin Breuker, Christoph Falschlunger, Elisabeth Fuchs, Ronald Micura
Publikováno v: Nucleic Acids Research
The catalytic strategies of small self-cleaving ribozymes often involve interactions between nucleobases and the ribonucleic acid (RNA) backbone. Here we show that multiply protonated, gaseous RNA has an intrinsic preference for the formation of ioni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c037b8272c00d10a1489d311551471
https://pubmed.ncbi.nlm.nih.gov/31276590
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10
Hatchet ribozyme structure and implications for cleavage mechanism
Autor: Christoph Falschlunger, Elisabeth Mairhofer, Luqian Zheng, Juncheng Wang, Shuguang Yuan, Kaiyi Huang, Ronald Micura, Aiming Ren, Dinshaw J. Patel
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Significance Self-cleaving ribozymes are RNAs that catalyze position-specific cleavage of their phosphodiester backbone. The cleavage site of the newly discovered hatchet ribozyme is located at the very 5′ end of its consensus secondary structure m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b710d83e457ef23b058a110195b0757
https://pubmed.ncbi.nlm.nih.gov/31088965
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