Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Christoph, Denk"'
Autor:
Daniel Lumpi, Hannes Mikula, Christoph Denk, Günter Allmaier, Christian Hametner, Dennis Svatunek, Gottfried Eilenberger
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
The strain‐promoted azide alkyne cycloaddition (SPAAC) is a powerful tool for forming covalent bonds between molecules even under physiological conditions, and therefore found broad application in fields ranging from biological chemistry and biomed
Autor:
Christoph Denk, Martin Wilkovitsch, Melanie Maurer, Thomas Wanek, Hannes Mikula, Severin Mairinger, Veronika Rosecker
Publikováno v:
Chembiochem
ChemBioChem
ChemBioChem
Radiotheranostics are designed by labeling targeting (bio)molecules with radionuclides for diagnostic or therapeutic application. Because the pharmacokinetics of therapeutic compounds play a pivotal role, chemically closely related imaging agents are
Autor:
Matthias M. Herth, Martin Wilkovitsch, Sture Lindegren, Emma Aneheim, Christoph Denk, Hannes Mikula, Holger Jensen
Publikováno v:
Chempluschem
ChemPlusChem
Denk, C, Wilkovitsch, M, Aneheim, E, Herth, M M, Jensen, H, Lindegren, S & Mikula, H 2019, ' Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking ', ChemPlusChem, vol. 219, no. 84, pp. 775-778 . https://doi.org/10.1002/cplu.201900114
ChemPlusChem
Denk, C, Wilkovitsch, M, Aneheim, E, Herth, M M, Jensen, H, Lindegren, S & Mikula, H 2019, ' Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking ', ChemPlusChem, vol. 219, no. 84, pp. 775-778 . https://doi.org/10.1002/cplu.201900114
In the past decade, several developments have expanded the chemical toolbox for astatination and the preparation of 211At‐labeled radiopharmaceuticals. However, there is still a need for advanced methods for the synthesis of astatinated (bio)molecu
Autor:
Matthias M. Herth, Christoph Denk, E. Johanna L. Stéen, Vladimir Shalgunov, Andreas Kjaer, Hannes Mikula, Jesper L. Kristensen
Publikováno v:
European Journal of Organic Chemistry. 2019:1722-1725
Fluorine-18 possesses outstanding decay characteristics for positron emission tomography (PET) imaging. Therefore, it is ideally suited for clinical applications. As such, improved strategies to incorporate fluorine-18 into bioactive molecules are of
Autor:
Kelsey A. Stoerzinger, Eszter Baráth, Yue Liu, Johannes A. Lercher, Libor Kovarik, Sebastian Foraita, Christoph Denk
Publikováno v:
Catalysis Science & Technology. 9:2620-2629
Hydrodeoxygenation of stearic acid on Ni/ZrO2 to n-heptadecane occurs via the reduction to 1-octadecanal, followed by decarbonylation of the aldehyde to n-heptadecane. Stearic acid binds stronger than 1-octadecanal on Ni, causing decarbonylation to s
Autor:
E Johanna L, Stéen, Jesper T, Jørgensen, Christoph, Denk, Umberto M, Battisti, Kamilla, Nørregaard, Patricia E, Edem, Klas, Bratteby, Vladimir, Shalgunov, Martin, Wilkovitsch, Dennis, Svatunek, Christian B M, Poulie, Lars, Hvass, Marina, Simón, Thomas, Wanek, Raffaella, Rossin, Marc, Robillard, Jesper L, Kristensen, Hannes, Mikula, Andreas, Kjaer, Matthias M, Herth
Publikováno v:
ACS pharmacologytranslational science. 4(2)
The development of highly selective and fast biocompatible reactions for ligation and cleavage has paved the way for new diagnostic and therapeutic applications of pretargeted
Publikováno v:
Synlett. 29:1297-1302
The fast and biocompatible ligation of 1,2,4,5-tetrazines with strained alkenes has found numerous applications in biomedical sciences. The reactivity of a 1,2,4,5-tetrazine can generally be tuned by changing its electronic properties by varying the
Publikováno v:
Monatshefte für Chemie-Chemical Monthly
Monatshefte Fur Chemie
Monatshefte Fur Chemie
The tetrazine ligation is one of the fastest bioorthogonal ligations and plays a pivotal role in time-critical in vitro and in vivo applications. However, prediction of the reactivity of tetrazines in inverse electron demand Diels–Alder-initiated l
Autor:
Christoph Denk, Stefania Specchia, Pankaj Madkikar, Thomas Mittermeier, Alessandro Hugo Monteverde Videla, Xiaodong Wang, Michele Piana, Hubert A. Gasteiger
Publikováno v:
Journal of Nanostructure in Chemistry, Vol 7, Iss 2, Pp 133-147 (2017)
We report here the synthesis of carbon-supported ZrO2 nanoparticles from zirconium oxyphthalocyanine (ZrOPc) and acetylacetonate [Zr(acac)4]. Using thermogravimetric analysis (TGA) coupled with mass spectrometry (MS), we could investigate the thermal
Autor:
Johannes Fröhlich, Dennis Svatunek, Hannes Mikula, Christoph Denk, Thomas Filip, Martin Wilkovitsch, Claudia Kuntner, Thomas Wanek, Severin Mairinger, Philipp Skrinjar
Publikováno v:
Organic & Biomolecular Chemistry. 15:5976-5982
In recent years, radiofluorinated alkyl azides have been reported for click radiolabeling and pretargeted PET imaging, but only little is known about the biodistribution and metabolism of these compounds. In this work, we present a significantly impr