Výsledky vyhledávání - "Christoph, Ballestrem"

Akademický článek

The structural basis of the talin–KANK1 interaction that coordinates the actin and microtubule cytoskeletons at focal adhesions

Autor: Xingchen Li, Benjamin Thomas Goult, Christoph Ballestrem, Thomas Zacharchenko

Publikováno v: Open Biology, Vol 13, Iss 6 (2023)

Adhesion between cells and the extracellular matrix is mediated by heterodimeric (αβ) integrin receptors that are intracellularly linked to the contractile actomyosin machinery. One of the proteins that control this link is talin, which organizes c

Externí odkaz: https://doaj.org/article/b147206a1b06497fbd4dc1bb19c95fc0

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Proximity mapping of desmosomes reveals a striking shift in their molecular neighbourhood associated with maturation

Autor: Judith B. Fülle, Rogerio Alves de Almeida, Craig Lawless, Bian Yanes, E. Birgitte Lane, David R. Garrod, Christoph Ballestrem

Desmosomes are multiprotein adhesion complexes that link intermediate filaments to the plasma membrane, ensuring the mechanical integrity of cells across tissues, but how they participate in the wider signalling network to exert their full function i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12b6df79d02ba01b6e4b79c3026310b8
https://doi.org/10.1101/2023.03.24.534085

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Tensin3 interaction with talin drives the formation of fibronectin-associated fibrillar adhesions

Autor: Paul Atherton, Rafaella Konstantinou, Suat Peng Neo, Emily Wang, Eleonora Balloi, Marina Ptushkina, Hayley Bennett, Kath Clark, Jayantha Gunaratne, David Critchley, Igor Barsukov, Edward Manser, Christoph Ballestrem

Publikováno v: Atherton, P, Konstantinou, R, Neo, S P, Wang, E, Balloi, E, Ptushkina, M, Bennett, H, Clark, K, Gunaratne, J, Critchley, D, Barsukov, I, Manser, E & Ballestrem, C 2022, ' Tensin3 interaction with talin drives the formation of fibronectin-associated fibrillar adhesions ', Journal of Cell Biology, vol. 221, no. 10, e202107022 . https://doi.org/10.1083/jcb.202107022

The formation of healthy tissue involves continuous remodeling of the extracellular matrix (ECM). Whilst it is known that this requires integrin-associated cell-ECM adhesion sites (CMAs) and actomyosin-mediated forces, the underlying mechanisms remai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ad7fc8074066f48967fc1a884157d3
https://doi.org/10.1083/jcb.202107022

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Desmosome dualism – most of the junction is stable, but a plakophilin moiety is persistently dynamic

Autor: David Liebl, Graham D. Wright, Christoph Ballestrem, David R Garrod, Jaron Liu, Rogerio Alves de Almeida, Henri Huppert, Bian Yanes, E. Birgitte Lane, Judith B Fülle

Publikováno v: J Cell Sci

Desmosomes, strong cell–cell junctions of epithelia and cardiac muscle, link intermediate filaments to cell membranes and mechanically integrate cells across tissues, dissipating mechanical stress. They comprise five major protein classes – desmo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f724e5c4e47da3aeae0274a15ca96a8a
https://doi.org/10.1242/jcs.258906

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Vinculin is required for neuronal mechanosensing but not for axon outgrowth

Autor: Ashwaq Albaraky, Karin A. Jansen, Cristina Melero, Paul Atherton, Kristian Franze, Federico Dajas-Bailador, Andrea Dimitracopoulos, Christoph Ballestrem, Adam J Reid, De Yao Wang

Publikováno v: Wang, D, Melero, C, Albaraky, A, Atherton, P, Jansen, K A, Dimitracopoulos, A, Dajas-bailador, F, Reid, A, Franze, K & Ballestrem, C 2021, ' Vinculin is required for neuronal mechanosensing but not for axon outgrowth ', Experimental Cell Research . https://doi.org/10.1016/j.yexcr.2021.112805

Integrin receptors are transmembrane proteins that bind to the extracellular matrix (ECM). In most animal cell types integrins cluster together with adaptor proteins at focal adhesions that sense and respond to external mechanical signals. In the cen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116bd4f815801e0926646f95e089525e
https://doi.org/10.1016/j.yexcr.2021.112805

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The βI domain promotes active β1 integrin clustering into mature adhesion sites

Autor: Giulia Mana, Donatella Valdembri, Janet A Askari, Zhenhai Li, Patrick Caswell, Cheng Zhu, Martin J Humphries, Christoph Ballestrem, Guido Serini

Publikováno v: Life Science Alliance. 6:e202201388

Modulation of integrin function is required in many physiological and pathological settings, such as angiogenesis and cancer. Integrin allosteric changes, clustering, and trafficking cooperate to regulate cell adhesion and motility on extracellular m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80bf0e578ea4d1a3c8df86ccb11f7625
https://doi.org/10.26508/lsa.202201388

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Tensin3 interaction with talin drives formation of fibronectin-associated fibrillar adhesions

Autor: Igor L. Barsukov, Eleonora Balloi, David R. Critchley, Rafaella Konstantinou, Suat Peng Neo, Emily C.S. Wang, Hayley M. Bennett, Kath Clark, Jayantha Gunaratne, Paul Atherton, Marina Ptushkina, Edward Manser, Christoph Ballestrem

The formation of healthy tissue involves continuous remodelling of the extracellular matrix (ECM). Whilst it is known that this requires integrin-associated cell-ECM adhesion sites (CMAs) and actomyosin-mediated forces, the underlying mechanisms rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6df1a0020b30dad9f45e4f7f3e32c35
https://doi.org/10.1101/2021.07.16.452612

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Desmosomal dualism: the core is stable while plakophilin is dynamic

Autor: Christoph Ballestrem, Garrod Dr, Lane Eb, Jianjun Liu, Fulle Jb, Huppert H, Alves de Almeida R, David Liebl, Graham D. Wright, Yanes B

Desmosomes, strong cell-cell junctions of epithelia and cardiac muscle, link intermediate filaments to cell membranes and mechanically integrate cells across tissues, dissipating mechanical stress. They comprise 5 major protein classes - desmocollins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a295781c2a221f6ddd46f67cee5f374
https://doi.org/10.1101/2021.03.02.433631

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Estimation of Cell Cycle States of Human Melanoma Cells with Quantitative Phase Imaging and Deep Learning

Autor: Timothy F. Cootes, Robert J. Ju, Tristan Henser-Brownhill, Christoph Ballestrem, Samantha J. Stehbens, Nikolas K. Haass

Publikováno v: Henser-brownhill, T, Ju, R J, Haass, N K, Stehbens, S J, Ballestrem, C & Cootes, T F 2020, Estimation of Cell Cycle States of Human Melanoma Cells with Quantitative Phase Imaging and Deep Learning . in 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI) . IEEE, pp. 1617-1621, 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), 3/04/20 . https://doi.org/10.1109/ISBI45749.2020.9098458
ISBI

Visualization and classification of cell cycle stages in live cells requires the introduction of transient or stably expressing fluorescent markers. This is not feasible for all cell types, and can be time consuming to implement. Labelling of living

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534e341cbfa2c8f990c5f21effd7eace
https://pure.manchester.ac.uk/ws/files/192832219/ISBI20_0130_FI_for_repository.pdf

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Relief of talin autoinhibition triggers a force-independent association with vinculin

Autor: Igor L. Barsukov, Franziska Lausecker, Christoph Ballestrem, Andrew P. Gilmore, David R. Critchley, Alexandre F. Carisey, Paul Atherton

Publikováno v: Atherton, P, Lausecker, F, Carisey, A, Gilmore, A, Critchley, D, Barsukov, I & Ballestrem, C 2020, ' Relief of talin autoinhibition triggers a force-independent association with vinculin ', The Journal of cell biology, vol. 219, no. 1 . https://doi.org/10.1083/jcb.201903134
JOURNAL OF CELL BIOLOGY
The Journal of Cell Biology
Atherton, P, Lausecker, F, Carisey, A, Gilmore, A, Critchley, D, Barsukov, I & Ballestrem, C 2019, ' Relief of talin autoinhibition triggers a force-independent association with vinculin ', The Journal of cell biology, vol. 219, no. 1, e201903134, pp. 1-16 . https://doi.org/10.1083/jcb.201903134

Talin and vinculin control mechanosensing by linking adhesion receptors to the contractile actin cytoskeleton. Using a mitochondrial targeting system, Atherton et al. elucidate mechanisms regulating conformational changes required for vinculin bindin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b9e39aa3f56a04f10d008fdc73da8c
https://www.research.manchester.ac.uk/portal/en/publications/relief-of-talin-autoinhibition-triggers-a-forceindependent-association-with-vinculin(bb6e044b-4af7-4453-ae9a-c09b2c22400e).html

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