Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression.

Autor: SoRelle ED; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.; Duke Center for Virology, Durham, North Carolina, United States of America., Haynes LE; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.; Duke Center for Virology, Durham, North Carolina, United States of America., Willard KA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.; Duke Center for Virology, Durham, North Carolina, United States of America., Chang B; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, United States of America., Ch'ng J; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America., Christofk H; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States of America., Luftig MA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, United States of America.; Duke Center for Virology, Durham, North Carolina, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2024 Oct 24; Vol. 20 (10), pp. e1012341. Date of Electronic Publication: 2024 Oct 24 (Print Publication: 2024).

Segregation, immunohistochemical, molecular and functional analyses classify a novel missense variant in fumarate hydratase (FH) as pathogenic.

Autor: Ouchene L; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Quebec, Canada.; Division of Dermatology, Department of Medicine, McGill University, Montréal, Québec, Canada., Wilde B; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA.; Jonnson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA., Chan-Pak-Choon F; Department of Human Genetics, McGill University, Montréal, Québec, Canada., Camacho Valenzuela J; Department of Human Genetics, McGill University, Montréal, Québec, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of the McGill University Health Centre, Montreal, Québec, Canada., Brimo F; Department of Pathology, McGill University, Montreal, Québec, Canada., Witkowski L; Department of Human Genetics, McGill University, Montréal, Québec, Canada.; Core Molecular Diagnostic Laboratory, McGill University Health Centre, Montreal, Quebec, Canada., Christofk H; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, California, USA.; Jonnson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.; Broad Stem Cell Research Center, University of California Los Angeles, Los Angeles, California, USA., Domecq C; Division of Medical Genetics, Department of Specialized Medicine, McGill University Health Centre, Montreal, Quebec, Canada., Fu L; Department of Pathology, McGill University, Montreal, Québec, Canada., Weber E; Department of Human Genetics, McGill University, Montréal, Québec, Canada.; Division of Medical Genetics, Department of Specialized Medicine, McGill University Health Centre, Montreal, Quebec, Canada., Lemieux Anglin B; Division of Medical Genetics, Department of Specialized Medicine, McGill University Health Centre, Montreal, Quebec, Canada.; Division of Medical Genetics, Department of Specialized Medicine, and Cancer Axis, Lady Davis Institute for Medical Research Jewish General Hospital, Montreal, Quebec, Canada., Netchiporouk E; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Quebec, Canada.; Division of Dermatology, Department of Medicine, McGill University, Montréal, Québec, Canada., Foulkes WD; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, Quebec, Canada.; Department of Human Genetics, McGill University, Montréal, Québec, Canada.; Cancer Research Program, Centre for Translational Biology, The Research Institute of the McGill University Health Centre, Montreal, Québec, Canada.; Division of Medical Genetics, Department of Specialized Medicine, McGill University Health Centre, Montreal, Quebec, Canada.; Division of Medical Genetics, Department of Specialized Medicine, and Cancer Axis, Lady Davis Institute for Medical Research Jewish General Hospital, Montreal, Quebec, Canada.

Publikováno v: Genes, chromosomes & cancer [Genes Chromosomes Cancer] 2024 Feb; Vol. 63 (2), pp. e23221.

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Metabolic decisions in development and disease-a Keystone Symposia report.

Autor: Cable J; PhD Science Writer, New York, New York., Pourquié O; Department of Genetics, Harvard Medical School, Boston, Massachusetts.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Stem Cell Institute, Boston, Massachusetts., Wellen KE; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Finley LWS; Cell Biology Program and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York., Aulehla A; Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Gould AP; The Francis Crick Institute, London, UK., Teleman A; German Cancer Research Center (DKFZ) and Heidelberg University, Heidelberg, Germany., Tu WB; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California., Garrett WS; Harvard T. H. Chan School of Public Health and Dana-Farber Cancer, Boston, Massachusetts., Miguel-Aliaga I; MRC London Institute of Medical Sciences and Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK., Perrimon N; Department of Genetics, Blavatnik Institute, Harvard Medical School and Howard Hughes Institute, Boston, Massachusetts., Hooper LV; Department of Immunology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas., Walhout AJM; Program in Systems Biology and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts., Wei W; Department of Pathology, Stanford University School of Medicine, Stanford, California.; Department of Biology and Stanford ChEM-H, Stanford University, Stanford, California., Alexandrov T; Structural and Computational Biology Unit and Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California., Erez A; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Ralser M; Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.; Department of Biochemistry, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Rabinowitz JD; Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey., Hemalatha A; Department of Genetics, Yale School of Medicine, New Haven, Connecticut., Gutiérrez-Pérez P; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria., Chandel NS; Department of Medicine, Robert H. Lurie Cancer Center, Chicago, Illinois.; Department of Biochemistry and Molecular Genetics, Robert H. Lurie Cancer Center Metabolomics Core, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Rutter J; Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah., Locasale JW; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina., Landoni JC; Research Program in Stem Cells and Metabolism, University of Helsinki, Helsinki, Finland., Christofk H; Departments of Biological Chemistry and Molecular & Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.

Publikováno v: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2021 Dec; Vol. 1506 (1), pp. 55-73. Date of Electronic Publication: 2021 Aug 19.

More Metabolism!

Autor: Olzmann JA, Fendt SM, Shah YM, Vousden K, Chandel N, Horng T, Danial N, Tu B, Christofk H, Vander Heiden MG, Wellen K

Publikováno v: Molecular cell [Mol Cell] 2021 Sep 16; Vol. 81 (18), pp. 3659-3664.