Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails

Autor: Emma Probst Brandum, Astrid Sissel Jørgensen, Marina Barrio Calvo, Katja Spiess, Francis C. Peterson, Zhang Yang, Brian F. Volkman, Christopher T. Veldkamp, Mette Marie Rosenkilde, Christoffer Knak Goth, Gertrud Malene Hjortø

Publikováno v: Brandum, E P, Jørgensen, A S, Calvo, M B, Spiess, K, Peterson, F C, Yang, Z, Volkman, B F, Veldkamp, C T, Rosenkilde, M M, Goth, C K & Hjortø, G M 2022, ' Selective Boosting of CCR7-Acting Chemokines; Short Peptides Boost Chemokines with Short Basic Tails, Longer Peptides Boost Chemokines with Long Basic Tails ', International Journal of Molecular Sciences, vol. 23, no. 3, 1397 . https://doi.org/10.3390/ijms23031397
International Journal of Molecular Sciences, Vol 23, Iss 1397, p 1397 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1397

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 regulate the lymph node homing of dendritic cells and naïve T-cells and the following induction of a motile DC-T cell priming state. Although CCL19 and CCL21 bind CCR7 with similar affiniti

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