Zobrazeno 1 - 10 of 91 pro vyhledávání: '"Christoffer, Bundgaard"'
1
Akademický článek
The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells
Autor: Nana Svane, Alberte Bay Villekjær Pedersen, Anne Rodenberg, Burak Ozgür, Lasse Saaby, Christoffer Bundgaard, Mie Kristensen, Peer Tfelt-Hansen, Birger Brodin
Publikováno v: Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Background Triptans are anti-migraine drugs with a potential central site of action. However, it is not known to what extent triptans cross the blood–brain barrier (BBB). The aim of this study was therefore to determine if triptans pass th
Externí odkaz: https://doaj.org/article/b334ddd2966948df88ef0d2a29430da2
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2
Akademický článek
Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution
Autor: Kristine Langthaler, Christopher R. Jones, Lasse Saaby, Christoffer Bundgaard, Birger Brodin
Publikováno v: Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Intro: Reliable estimates of drug uptake from blood to brain parenchyma are crucial in CNS drug discovery and development. While in vivo Kp,uu,brain estimates are the gold standard for investigating brain drug disposition, animal usage is a
Externí odkaz: https://doaj.org/article/335b4fcb2320446ba12246e0fb8eecc1
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5
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
Autor: Irena Loryan, Andreas Reichel, Bo Feng, Christoffer Bundgaard, Christopher Shaffer, Cory Kalvass, Dallas Bednarczyk, Denise Morrison, Dominique Lesuisse, Edmund Hoppe, Georg C. Terstappen, Holger Fischer, Li Di, Nicola Colclough, Scott Summerfield, Stephen T. Buckley, Tristan S. Maurer, Markus Fridén
Publikováno v: Pharmaceutical Research. 39:1321-1341
Purpose More than 15 years have passed since the first description of the unbound brain-to-plasma partition coefficient (Kp,uu,brain) by Prof. Margareta Hammarlund-Udenaes, which was enabled by advancements in experimental methodologies including cer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450f3186fa63b212c77d3ed7977fbf35
https://doi.org/10.1007/s11095-022-03246-6
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6
Practical Application of Rodent Transporter Knockout Models to Assess Brain Penetration in Drug Discovery
Autor: Elin, Eneberg, Christopher R, Jones, Thomas, Jensen, Kristine, Langthaler, Christoffer, Bundgaard
Publikováno v: Drug Metabolism and Bioanalysis Letters. 15:12-21
Background & Objective: Compound X is a drug candidate for the treatment of neurodegenerative diseases. Its brain distribution was evaluated as part of the lead identification and optimization activities undertaken in early drug discovery. Methods: T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95428b4988e820ca3e970fb9b656fb8
https://doi.org/10.2174/1872312815666220222091032
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7
Akademický článek
Target-Mediated Brain Tissue Binding for Small Molecule Inhibitors of Heat Shock Protein 90
Autor: Lassina Badolo, Kenneth Thirstrup, Søren Møller Nielsen, Ask Püschl, Thomas Jensen, Steve Watson, Christoffer Bundgaard
Publikováno v: Pharmaceutics, Vol 12, Iss 11, p 1009 (2020)
Drug distribution in the brain is generally associated with an affinity for fatty brain tissues and therefore known to be species- and concentration-independent. We report here the effect of target affinity on brain tissue binding for 10 small molecu
Externí odkaz: https://doaj.org/article/bc746fabbc864499855246d15fe4e287
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8
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established
Autor: Kristine, Langthaler, Christopher R, Jones, Rasmus B, Christensen, Elin, Eneberg, Birger, Brodin, Christoffer, Bundgaard
Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 52(6)
The use of the Göttingen minipig as an animal model for drug safety testing and prediction of human pharmacokinetics (PK) continues to gain momentum in pharmaceutical research and development. The aim of this study was to evaluate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::584417b35aa014d2d8c0f47b083d03df
https://pubmed.ncbi.nlm.nih.gov/36000364
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10
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies
Autor: Kristine Langthaler, Christopher R. Jones, Rasmus B. Christensen, Elin Eneberg, Birger Brodin, Christoffer Bundgaard
Publikováno v: Langthaler, K, Jones, C R, Christensen, R B, Eneberg, E, Brodin, B & Bundgaard, C 2022, ' Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies ', Xenobiotica, vol. 52, no. 6, pp. 591-607 . https://doi.org/10.1080/00498254.2022.2115425
1. The use of the Göttingen minipig as an animal model for drug safety testing and prediction of human pharmacokinetics (PK) continues to gain momentum in pharmaceutical research and development. The aim of this study was to evaluate in vitro to in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9a985090dc52f86a8ea6da97f6ab96
https://curis.ku.dk/portal/da/publications/characterisation-of-intravenous-pharmacokinetics-in-goettingen-minipig-and-clearance-prediction-using-established-in-vitro-to-in-vivo-extrapolation-methodologies(04651409-04f2-4166-9cde-13f0f77f14d0).html
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