Zobrazeno 1 - 10
of 2 067
pro vyhledávání: '"Christoffels A."'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2964-2977 (2024)
Artificial Intelligence is transforming drug discovery, particularly in the hit identification phase of therapeutic compounds. One tool that has been instrumental in this transformation is Quantitative Structure-Activity Relationship (QSAR) analysis.
Externí odkaz:
https://doaj.org/article/13bc196e36e14e1a8560a9f8872d564e
Autor:
Michael L. le Roux, Renaldo Christoffels, Roland Kroukamp, Jennie Morgan, Omotayo S. Alaofin, Tasleem Ras, Klaus B. von Pressentin
Publikováno v:
South African Family Practice, Vol 66, Iss 1, Pp e1-e8 (2024)
Background: Our study focuses on vasectomies, an underutilised contraception method worldwide. Little is known about post-vasectomy semen analysis (PVSA) adherence in our setting, which is an essential step in confirming the procedure’s success. We
Externí odkaz:
https://doaj.org/article/bb2dca7411f14be2b1ca65e36cf7b943
Autor:
Nicki Tiffin, Anja Bedeker, Michelle Nichols, Tsaone Tamuhla, Peter van Heusden, Emma J Griffiths, Eddie T Lulamba, Alan Christoffels
Publikováno v:
BMJ Global Health, Vol 9, Iss 10 (2024)
Microbial data sharing underlies evidence-based microbial research, as well as pathogen surveillance and analysis essential to public health. While the need for data sharing was highlighted during the SARS-CoV-2 pandemic, some concerns regarding seco
Externí odkaz:
https://doaj.org/article/2cfd0f4c7546438a86ece876576e7388
Autor:
Manon Baudic, Hiroshige Murata, Fernanda M. Bosada, Uirá Souto Melo, Takanori Aizawa, Pierre Lindenbaum, Lieve E. van der Maarel, Amaury Guedon, Estelle Baron, Enora Fremy, Adrien Foucal, Taisuke Ishikawa, Hiroya Ushinohama, Sean J. Jurgens, Seung Hoan Choi, Florence Kyndt, Solena Le Scouarnec, Vincent Wakker, Aurélie Thollet, Annabelle Rajalu, Tadashi Takaki, Seiko Ohno, Wataru Shimizu, Minoru Horie, Takeshi Kimura, Patrick T. Ellinor, Florence Petit, Yves Dulac, Paul Bru, Anne Boland, Jean-François Deleuze, Richard Redon, Hervé Le Marec, Thierry Le Tourneau, Jean-Baptiste Gourraud, Yoshinori Yoshida, Naomasa Makita, Claude Vieyres, Takeru Makiyama, Stephan Mundlos, Vincent M. Christoffels, Vincent Probst, Jean-Jacques Schott, Julien Barc
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract While 3D chromatin organization in topologically associating domains (TADs) and loops mediating regulatory element-promoter interactions is crucial for tissue-specific gene regulation, the extent of their involvement in human Mendelian disea
Externí odkaz:
https://doaj.org/article/973ce46b9b9a4d84b5710238b42950a4
Autor:
Li, Jiuru, Wiesinger, Alexandra, Fokkert, Lianne, Bakker, Priscilla, de Vries, Dylan K., Tijsen, Anke J., Pinto, Yigal M., Verkerk, Arie O., Christoffels, Vincent M., Boink, Gerard J.J., Devalla, Harsha D.
Publikováno v:
In Cell Stem Cell 7 November 2024 31(11):1667-1684
Publikováno v:
In Computational and Structural Biotechnology Journal December 2024 23:2964-2977
Autor:
Onywera, Harris, Ondoa, Pascale, Nfii, Faith, Ogwell, Ahmed, Kebede, Yenew, Christoffels, Alan, Tessema, Sofonias K *
Publikováno v:
In The Lancet Infectious Diseases February 2024 24(2):e106-e112
Autor:
Michael Karl Melzer, Silvia Schirge, Johann Gout, Frank Arnold, Dharini Srinivasan, Ingo Burtscher, Chantal Allgöwer, Medhanie Mulaw, Friedemann Zengerling, Cagatay Günes, Heiko Lickert, Vincent M. Christoffels, Stefan Liebau, Martin Wagner, Thomas Seufferlein, Christian Bolenz, Anne M. Moon, Lukas Perkhofer, Alexander Kleger
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background The reactivation of genetic programs from early development is a common mechanism for injury-induced organ regeneration. T-box 3 (TBX3) is a member of the T-box family of transcription factors previously shown to regulate pluripot
Externí odkaz:
https://doaj.org/article/d01ac3b5e56244e18b99989bd1a98642
Publikováno v:
Cells, Vol 13, Iss 11, p 931 (2024)
During mammalian heart development, the clustered genes encoding peptide hormones, Natriuretic Peptide A (NPPA; ANP) and B (NPPB; BNP), are transcriptionally co-regulated and co-expressed predominately in the atrial and ventricular trabecular cardiom
Externí odkaz:
https://doaj.org/article/8c2021fb649a4ec5b756aad508c1d1fc
Autor:
Marina Kaiser, Timo H. Lüdtke, Lena Deuper, Carsten Rudat, Vincent M. Christoffels, Andreas Kispert, Mark-Oliver Trowe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Inner hair cells are essential for hearing but the molecular drivers of their differentiation have remained enigmatic. Here, the authors show that the transcription factor TBX2 has a key function in inducing and maintaining inner hair cell fate.
Externí odkaz:
https://doaj.org/article/a1ed0988f76a43e0ad9f7df5cbd56ffb