Zobrazeno 1 - 10
of 2 043
pro vyhledávání: '"Christoffels, A."'
Autor:
Manon Baudic, Hiroshige Murata, Fernanda M. Bosada, Uirá Souto Melo, Takanori Aizawa, Pierre Lindenbaum, Lieve E. van der Maarel, Amaury Guedon, Estelle Baron, Enora Fremy, Adrien Foucal, Taisuke Ishikawa, Hiroya Ushinohama, Sean J. Jurgens, Seung Hoan Choi, Florence Kyndt, Solena Le Scouarnec, Vincent Wakker, Aurélie Thollet, Annabelle Rajalu, Tadashi Takaki, Seiko Ohno, Wataru Shimizu, Minoru Horie, Takeshi Kimura, Patrick T. Ellinor, Florence Petit, Yves Dulac, Paul Bru, Anne Boland, Jean-François Deleuze, Richard Redon, Hervé Le Marec, Thierry Le Tourneau, Jean-Baptiste Gourraud, Yoshinori Yoshida, Naomasa Makita, Claude Vieyres, Takeru Makiyama, Stephan Mundlos, Vincent M. Christoffels, Vincent Probst, Jean-Jacques Schott, Julien Barc
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract While 3D chromatin organization in topologically associating domains (TADs) and loops mediating regulatory element-promoter interactions is crucial for tissue-specific gene regulation, the extent of their involvement in human Mendelian disea
Externí odkaz:
https://doaj.org/article/973ce46b9b9a4d84b5710238b42950a4
Publikováno v:
Cells, Vol 13, Iss 11, p 931 (2024)
During mammalian heart development, the clustered genes encoding peptide hormones, Natriuretic Peptide A (NPPA; ANP) and B (NPPB; BNP), are transcriptionally co-regulated and co-expressed predominately in the atrial and ventricular trabecular cardiom
Externí odkaz:
https://doaj.org/article/8c2021fb649a4ec5b756aad508c1d1fc
Autor:
Onywera, Harris, Ondoa, Pascale, Nfii, Faith, Ogwell, Ahmed, Kebede, Yenew, Christoffels, Alan, Tessema, Sofonias K *
Publikováno v:
In The Lancet Infectious Diseases February 2024 24(2):e106-e112
Autor:
Michael Karl Melzer, Silvia Schirge, Johann Gout, Frank Arnold, Dharini Srinivasan, Ingo Burtscher, Chantal Allgöwer, Medhanie Mulaw, Friedemann Zengerling, Cagatay Günes, Heiko Lickert, Vincent M. Christoffels, Stefan Liebau, Martin Wagner, Thomas Seufferlein, Christian Bolenz, Anne M. Moon, Lukas Perkhofer, Alexander Kleger
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background The reactivation of genetic programs from early development is a common mechanism for injury-induced organ regeneration. T-box 3 (TBX3) is a member of the T-box family of transcription factors previously shown to regulate pluripot
Externí odkaz:
https://doaj.org/article/d01ac3b5e56244e18b99989bd1a98642
Akademický článek
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Autor:
Marina Kaiser, Timo H. Lüdtke, Lena Deuper, Carsten Rudat, Vincent M. Christoffels, Andreas Kispert, Mark-Oliver Trowe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Inner hair cells are essential for hearing but the molecular drivers of their differentiation have remained enigmatic. Here, the authors show that the transcription factor TBX2 has a key function in inducing and maintaining inner hair cell fate.
Externí odkaz:
https://doaj.org/article/a1ed0988f76a43e0ad9f7df5cbd56ffb
Publikováno v:
Cells, Vol 13, Iss 1, p 4 (2023)
Genetic predisposition to cardiac arrhythmias has been a field of intense investigation. Research initially focused on rare hereditary arrhythmias, but over the last two decades, the role of genetic variation (single nucleotide polymorphisms) in hear
Externí odkaz:
https://doaj.org/article/a1f52b61732b4da9b6f1177aa5685e25
Autor:
Manal Alaamery, Nour Albesher, Fahad Alhabshan, Phil Barnett, Mohamed Salim Kabbani, Farah Chaikhouni, Aho Ilgun, Olaf R. F. Mook, Hessa Alsaif, Vincent M. Christoffels, Peter van Tintelen, Arthur A. M. Wilde, Arjan C. Houweling, Salam Massadeh, Alex V. Postma
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 10, Iss 11, p 455 (2023)
Background: Congenital heart diseases (CHD) are the most common congenital malformations in newborns and remain the leading cause of mortality among infants under one year old. Molecular diagnosis is crucial to evaluate the recurrence risk and to add
Externí odkaz:
https://doaj.org/article/9f1524d26e144b9f88b2e4419e250bd4
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/f53c47389ae242b1b6f399be3266fdfe
Autor:
John Juma, Vagner Fonseca, Samson L. Konongoi, Peter van Heusden, Kristina Roesel, Rosemary Sang, Bernard Bett, Alan Christoffels, Tulio de Oliveira, Samuel O. Oyola
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Genetic evolution of Rift Valley fever virus (RVFV) in Africa has been shaped mainly by environmental changes such as abnormal rainfall patterns and climate change that has occurred over the last few decades. These gradual environmental chan
Externí odkaz:
https://doaj.org/article/f132237c98ed4bfe8c0967f19fe4009d