Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Christof Straub"'
Autor:
Chen Xi Yang, Michael Tomchaney, Manuel F. Landecho, Borja R. Zamacona, Marta Marin Oto, Javier Zulueta, Joshua Malo, Steve Knoper, Marco Contoli, Alberto Papi, Dragoş M. Vasilescu, Maor Sauler, Christof Straub, Cheryl Tan, Fernando D. Martinez, Deepta Bhattacharya, Ivan O. Rosas, Farrah Kheradmand, Tillie-Louise Hackett, Francesca Polverino
Publikováno v:
Cells, Vol 11, Iss 12, p 1864 (2022)
People with pre-existing lung diseases such as chronic obstructive pulmonary disease (COPD) are more likely to get very sick from SARS-CoV-2 disease 2019 (COVID-19). Still, an interrogation of the immune response to COVID-19 infection, spatially thro
Externí odkaz:
https://doaj.org/article/f35c19a12ef84ec790212f56ff5e12f7
Autor:
Susan Stafford, Wendy I. White, Christof Straub, Alexander Kurosky, Konrad Pazdrak, William J. Calhoun, Rosario Maroto
The mechanisms contributing to persistent eosinophil activation and poor eosinopenic response to glucocorticoids in severe asthma are poorly defined. We examined the effect of cytokines typically overexpressed in the asthmatic airways on glucocortico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d70a0feadae15e4ee2bac83c4ea0920
https://europepmc.org/articles/PMC5098561/
https://europepmc.org/articles/PMC5098561/
Publikováno v:
Apoptosis : an international journal on programmed cell death. 21(4)
The mainstay of asthma therapy, glucocorticoids (GCs) exert their therapeutic effects through the inhibition of inflammatory signaling and induction of eosinophil apoptosis. However, laboratory and clinical observations of GC-resistant asthma suggest
Autor:
Kohei Oda, Koichi Kurahara, Felix Hahn, Johannes Betge, Eri Takeshita, Irina Leonardi, Soichiro Ishihara, Norma Quintanilla, Alexandra Gerstgrasser, Tianzuo Zhan, Thomas Hielscher, Kazushige Kawai, Toshiaki Tanaka, Tadahiko Fuchigami, Shimpei Shirai, Hidenori Matsui, Shuji Kanmura, Anthony P. Olive, Tomomichi Kiyomatsu, Yuichiro Tanaka, Kizhake V. Soman, Kensuke Otani, Shunichi Yanai, Kazuma Fujimoto, Claudia Gottier, Druckerei Stückle, Yoichiro Ito, Girish Hiremath, Gerhard Rogler, Takayuki Matsumoto, Motoyasu Kusano, Tamotsu Sugai, Masahiko Nakamura, Hiroki Taguchi, Takashi Ohyama, Hiroyoshi Endo, Koji Murono, Hiroaki Nozawa, Nanae Tsuruoka, Yuzo Nagai, Anders Øverby, Stephanie Kasper, Christina Nance, Matthias P. Ebert, Sinead M. Smith, Hiroyuki Kobayashi, Alexander Kurosky, Natsuko Sakata, Isabelle Frey-Wagner, Toshiaki Watanabe, Hirohatu Kawakubo, Colm O'Morain, Keisuke Kawasaki, Hitoshi Setoyama, Yumi Oshiro, Corinna Hauf, Tomomi Yoshioka, Christof Straub, Keiji Matsunaga, Michael Scharl, Kayo Akutagawa, Megumi Hara, Kalpesh Thakkar, Shotaro Nakamura, Hironori Yamaguchi, Carla M. Davis, Yuichiro Nasu, John E. Wiktorowicz, Koji Yasuda, Shiho Arima, Anne Fischbeck-Terhalle, Shinichi Hashimoto, Hitomi Hamamoto, Toshihiro Fujita, Somay Yamagata Murayama, Konrad Pazdrak, Yasuhisa Sakata, Akio Ido, Fumisato Sasaki, Tina Raselli, Ryuichi Iwakiri, Marianne R. Spalinger, Takeshi Nishikawa, Kirstin Atrott, Keisuke Hata, Yuko Morinaga, Sebastian Belle
Publikováno v:
Digestion. 93
Autor:
Christof Straub, Susan Stafford, Zheng Wu, Travis W. Young, Anthony M. Haag, Robert D. English, Alexander Kurosky, Konrad Pazdrak, John E. Wiktorowicz, Kizhake V. Soman
Publikováno v:
PROTEOMICS - Clinical Applications. 3:1151-1173
Eosinophils are granular leukocytes that have significant roles in many inflammatory and immunoregulatory responses, especially asthma and allergic diseases. We have undertaken a fairly comprehensive proteomic analysis of purified peripheral blood eo
Cross-Talk between ICAM-1 and GM-CSF Receptor Signaling Modulates Eosinophil Survival and Activation
Autor:
Konrad Pazdrak, Christof Straub, Barbara Olszewska-Pazdrak, Allan R. Brasier, V. Starosta, Alexander Kurosky, Travis W. Young, Susan Stafford
Publikováno v:
The Journal of Immunology. 180:4182-4190
Reversal of eosinophilic inflammation has been an elusive therapeutic goal in the management of asthma pathogenesis. In this regard, GM-CSF is a primary candidate cytokine regulating eosinophil activation and survival in the lung; however, its molecu
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 186(11)
The priming of eosinophils by cytokines leading to augmented response to chemoattractants and degranulating stimuli is a characteristic feature of eosinophils in the course of allergic inflammation and asthma. Actin reorganization and integrin activa
Autor:
Alexander Kurosky, Cesar Sanchez, Konrad Pazdrak, Martin Montes, Luis Carlos Watanabe, Christof Straub, A. Clinton White, Jason P. Burnham
We used comparative proteomics to analyze eosinophils from a patient with hypereosinophilia due to fascioliasis. Using 2-dimensional electrophoresis and mass spectrometry, we demonstrated that the eosinophil proteome was significantly altered compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378a0db0596a84d61c653a5ea7d41d2d
https://hdl.handle.net/20.500.12866/10993
https://hdl.handle.net/20.500.12866/10993
Autor:
Konrad, Pazdrak, Travis W, Young, Susan, Stafford, Barbara, Olszewska-Pazdrak, Christof, Straub, Vitaliy, Starosta, Allan, Brasier, Alexander, Kurosky
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 180(6)
Reversal of eosinophilic inflammation has been an elusive therapeutic goal in the management of asthma pathogenesis. In this regard, GM-CSF is a primary candidate cytokine regulating eosinophil activation and survival in the lung; however, its molecu
Autor:
Alexander Kurosky, Melinda Mata, Anthony Olive, Christof Straub, John E. Wiktorowicz, Christina L. Nance, Kizhake V. Soman, Girish Hiremath, Konrad Pazdrak, Norma M. Quintanilla, Carla M. Davis
Publikováno v:
Gastroenterology. 148:S-52