Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Christof Osman"'
Autor:
Eelco van Anken, David Pincus, Scott Coyle, Tomás Aragón, Christof Osman, Federica Lari, Silvia Gómez Puerta, Alexei V Korennykh, Peter Walter
Publikováno v:
eLife, Vol 3 (2014)
Insufficient protein-folding capacity in the endoplasmic reticulum (ER) induces the unfolded protein response (UPR). In the ER lumen, accumulation of unfolded proteins activates the transmembrane ER-stress sensor Ire1 and drives its oligomerization.
Externí odkaz:
https://doaj.org/article/c6817a80e37e4180bc5d1af037ef86b9
Autor:
Andrew Murley, Laura L Lackner, Christof Osman, Matthew West, Gia K Voeltz, Peter Walter, Jodi Nunnari
Publikováno v:
eLife, Vol 2 (2013)
Mitochondrial division is important for mitochondrial distribution and function. Recent data have demonstrated that ER–mitochondria contacts mark mitochondrial division sites, but the molecular basis and functions of these contacts are not understo
Externí odkaz:
https://doaj.org/article/afcfbf8868544b1da1f95b827db1e1a3
Autor:
Rupa Banerjee, Vanessa Trauschke, Nils Bertram, Ina Aretz, Christof Osman, Don C. Lamb, Dejana Mokranjac
Functional mitochondria are essential for cell viability and depend on protein import from the cytosol. Impaired protein import initiates various well-characterized cellular programs that rescue or remove dysfunctional mitochondria. However, the mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df422709cb36ef2702b19f8c42cf6fa
https://doi.org/10.1101/2022.09.05.506649
https://doi.org/10.1101/2022.09.05.506649
The MS2-MCP imaging system is widely used to study the mRNA spatial distribution in living cells. Here, we report that the MS2-MCP system may destabilize the tagged mRNA by targeting it to the nonsense-mediated mRNA decay pathway. We introduce an imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a852adf41376e8245c31c0527c0c8c03
https://doi.org/10.1101/2022.02.05.479257
https://doi.org/10.1101/2022.02.05.479257
Publikováno v:
Bioinformatics
Summary Here, we introduce YeastMate, a user-friendly deep learning-based application for automated detection and segmentation of Saccharomyces cerevisiae cells and their mating and budding events in microscopy images. We build upon Mask R-CNN with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8dec51e1e18d1bfef321682f764da8
Autor:
Anika Seel, Francesco Padovani, Alissa Finster, Moritz Mayer, Daniela Bureik, Christof Osman, Till Klecker, Kurt M. Schmoller
To maintain stable DNA concentrations, proliferating cells need to coordinate DNA replication with cell growth. For nuclear DNA, eukaryotic cells achieve this by coupling DNA replication to cell cycle progression, ensuring that DNA is doubled exactly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56ca451a12794eeed721c7ae979c6e32
https://doi.org/10.1101/2021.12.03.471050
https://doi.org/10.1101/2021.12.03.471050
Here, we introduce YeastMate, a user-friendly deep learning-based application for automated detection and segmentation of Saccharomyces cerevisiae cells and their mating and budding events in microscopy images. We build upon Mask R-CNN with a custom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7301f1116b4679eb7cd2d543edfb54e
https://doi.org/10.1101/2021.10.13.464238
https://doi.org/10.1101/2021.10.13.464238
Autor:
Till Klecker, Christof Osman, David Bunk, David Hörl, Felix Thoma, Heinrich Leonhardt, Rodaria Roussou, Christina Schug, Andreas Maiser, Peter Walter, Christopher Jakubke
Publikováno v:
Science advances, vol 7, iss 36
Science Advances
Science Advances
Mitochondrial genomes (mtDNA) encode essential subunits of the mitochondrial respiratory chain. Mutations in mtDNA can cause a shortage in cellular energy supply, which can lead to numerous mitochondrial diseases. How cells secure mtDNA integrity ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4931bc826ab94f3119cba17e4d4acbe
https://escholarship.org/uc/item/7455x3k1
https://escholarship.org/uc/item/7455x3k1
Publikováno v:
Molecular Biology of the Cell
Molecular biology of the cell, vol 31, iss 7
Molecular biology of the cell, vol 31, iss 7
Mitochondrial function depends crucially on the maintenance of multiple mitochondrial DNA (mtDNA) copies. Surprisingly, the cellular mechanisms regulating mtDNA copy number remain poorly understood. Through a systematic high-throughput approach in Sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9acff954bdc3fa35d6a52d41528791
Publikováno v:
BIOspektrum. 24:586-589
Essential subunits of the respiratory chain are encoded by the mitochondrial DNA (mtDNA). To ensure cellular energy supply and organismal health, cells need to faithfully pass on mtDNA during cell division, dis - tribute copies of mtDNA through the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce2dc23235c7c34dd5aa119ae7c1b9ed
https://doi.org/10.1007/s12268-018-0961-2
https://doi.org/10.1007/s12268-018-0961-2