Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery.

Autor: Johannes Matschke, Alexander Bohla, Christof Maucksch, Rashmi Mittal, Carsten Rudolph, Joseph Rosenecker

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e24615 (2012)

Several barriers have to be overcome in order to achieve gene expression in target cells, e.g. cellular uptake, endosomal release and translocation to the nucleus. Nuclear localization sequences (NLS) enhance gene delivery by increasing the uptake of

Externí odkaz: https://doaj.org/article/411f447076e74ebdaf9d1634ae53bb22

Patient Satisfaction with the Etanercept Biosimilar SB4 Device, Among Rheumatoid Arthritis and Spondyloarthropathy Patients - A German Observational Study

Autor: Christof Maucksch, P. M. Aries, S. Zinke, Ulf Müller-Ladner

Publikováno v: The Open Rheumatology Journal. 14:7-14

Background: The etanercept biosimilar SB4 is a TNF inhibitor authorised for use as a targeted Biological Disease-Modifying Anti-Rheumatic Drug (bDMARD). Various administration devices have been developed for subcutaneous self-injection of bDMARDs. Ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1970ae68758b2595bf0bb1566344bd66
https://doi.org/10.2174/1874312902014010007

Redirection of doublecortin-positive cell migration by over-expression of the chemokines MCP-1, MIP-1α and GRO-α in the adult rat brain

Autor: S.K. Tang, Christof Maucksch, R.A. Knobloch, Bronwen Connor

Publikováno v: Neuroscience. 260:240-248

Inflammation-induced chemoattraction plays a major role in adult subventricular zone (SVZ)-derived precursor cell migration following neural cell loss, in particular through the release of chemokines by activated microglia and macrophages. We previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2c4b123d427fc694aec70b9f981f94
https://doi.org/10.1016/j.neuroscience.2013.12.022

Non-Viral Generation of Neural Precursor-like Cells from Adult Human Fibroblasts

Autor: Mirella Dottori, Bronwen Connor, Charlotte Butler-Munro, Erin Firmin, Johanna M. Montgomery, Christof Maucksch

Publikováno v: Journal of Stem Cells & Regenerative Medicine
Scopus-Elsevier
Journal of Stem Cells and Regenerative Medicine, Vol 8, Iss 3, Pp 162-170 (2012)

Recent studies have reported direct reprogramming of human fibroblasts to mature neurons by the introduction of defined neural genes. This technology has potential use in the areas of neurological disease modeling and drug development. However, use o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6949941e855a51eabd057c8b7f7aa4
http://europepmc.org/articles/PMC3908292

Characterization of Tailor-Made Copolymers of Oligo(ethylene glycol) Methyl Ether Methacrylate and N,N-Dimethylaminoethyl Methacrylate as Nonviral Gene Transfer Agents: Influence of Macromolecular Structure on Gene Vector Particle Properties and Transfection Efficiency

Autor: Özgür Akdemir, Monika M. Golas, Bjoern Sander, Senta Üzgün, Holger Stark, Christof Maucksch, Günther Hasenpusch, Jean-François Lutz, Rabea Imker, Carsten Rudolph

Publikováno v: Biomacromolecules
Uzgün, S, Akdemir, O, Hasenpusch, G, Maucksch, C, Golas, M M, Sander, B, Stark, H, Imker, R, Lutz, J-F & Rudolph, C 2010, ' Characterization of tailor-made copolymers of oligo(ethylene glycol) methyl ether methacrylate and N,N-dimethylaminoethyl methacrylate as nonviral gene transfer agents: influence of macromolecular structure on gene vector particle properties and transfection efficiency ', Biomacromolecules, vol. 11, no. 1, pp. 39-50 . https://doi.org/10.1021/bm9008759

Udgivelsesdato: 2010-Jan-11 Oligo(ethylene glycol) methyl ether methacrylates (OEGMA) of various chain lengths (i.e., 9, 23, or 45 EG units) and N,N-dimethylaminoethyl methacrylate (DMAEMA) were copolymerized by atom transfer radical polymerization (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05affccebe49013fa7e39d9aa5113202
https://doi.org/10.1021/bm9008759