Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christof Hiebel"'
Autor:
Debapriya Chakraborty, Vanessa Felzen, Christof Hiebel, Elisabeth Stürner, Natarajan Perumal, Caroline Manicam, Elisabeth Sehn, Franz Grus, Uwe Wolfrum, Christian Behl
Publikováno v:
Redox Biology, Vol 24, Iss , Pp - (2019)
Oxidative stress and a disturbed cellular protein homeostasis (proteostasis) belong to the most important hallmarks of aging and of neurodegenerative disorders. The proteasomal and autophagic-lysosomal degradation pathways are key measures to maintai
Externí odkaz:
https://doaj.org/article/ed04d6a2923e4977a7ca0bd92a5b19d9
Autor:
Christof Hiebel, Elisabeth Stürner, Meike Hoffmeister, Georg Tascher, Mario Schwarz, Heike Nagel, Christian Behrends, Christian Münch, Christian Behl
Publikováno v:
Cells, Vol 9, Iss 11, p 2416 (2020)
The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network. In response to stress, BAG3 specifically targets aggregation-prone proteins to the perinu
Externí odkaz:
https://doaj.org/article/80977d8e0fe24f80a9c6b018494a6305
Autor:
Elisabeth Sehn, Christian Behl, Christof Hiebel, Franz H. Grus, Vanessa Felzen, Uwe Wolfrum, Caroline Manicam, Natarajan Perumal, Debapriya Chakraborty, Elisabeth Stürner
Publikováno v:
Redox Biology
Redox Biology, Vol 24, Iss, Pp-(2019)
Redox Biology, Vol 24, Iss, Pp-(2019)
Oxidative stress and a disturbed cellular protein homeostasis (proteostasis) belong to the most important hallmarks of aging and of neurodegenerative disorders. The proteasomal and autophagic-lysosomal degradation pathways are key measures to maintai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cc330b09215555a3158f06dbb32cb3
http://europepmc.org/articles/PMC6454062
http://europepmc.org/articles/PMC6454062
Autor:
Christian Behl, Christof Hiebel
Publikováno v:
Life Sciences. 138:3-7
The two main receptors of the endocannabinoid system, cannabinoid receptors 1 (CB1R) and 2 (CB2R), were described in the early 1990s. Since then, different physiological functions have been revealed that are linked to the activity of these two G-prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d202532300110c2862c7c368c951d187
https://doi.org/10.1016/j.lfs.2015.03.020
https://doi.org/10.1016/j.lfs.2015.03.020
Autor:
Jana Renziehausen, Christian Behl, Christof Hiebel, Stefan Kins, Arpita Kundu, Heike Nagel, Parvana Hajieva, Donat Kögel
Publikováno v:
Journal of Alzheimer's Disease. 44:879-896
Alzheimer's disease (AD) is the major age-associated form of dementia characterized by gradual cognitive decline. Aberrant cleavage of the amyloid-β protein precursor (AβPP) is thought to play an important role in the pathology of this disease. Two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cabf1ca6f4ef432f9aed25416fa29b
https://doi.org/10.3233/jad-140600
https://doi.org/10.3233/jad-140600
Autor:
Rebecca Reilly, Eugene M. Dempsey, Christof Hiebel, Stephen J. Keely, Judith A. Coppinger, Christian Behl, Magdalena S. Mroz, Edward F. McKone, Kieran Wynne
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Deletion of phenylalanine 508 of the cystic fibrosis transmembrane conductance regulator (ΔF508 CFTR) is a major cause of cystic fibrosis (CF), one of the most common inherited childhood diseases. ΔF508 CFTR is a trafficking mutant that is retained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b64faa087ac07d4899e50c86542e66
https://doi.org/10.1038/s41598-017-06588-z
https://doi.org/10.1038/s41598-017-06588-z
Publikováno v:
Journal of Neurochemistry. 131:484-497
Cannabinoid Receptor 1 (CB1) has been initially described as the receptor for Delta-9-Tetrahydrocannabinol in the central nervous system (CNS), mediating retrograde synaptic signaling of the endocannabinoid system. Beside its expression in various CN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a224023d4ef6a4badbcb380c4cee8c
https://doi.org/10.1111/jnc.12839
https://doi.org/10.1111/jnc.12839
Autor:
Martin Purrio, Heike Nagel, Angela B. Clement, Christoph Stumm, Beat Lutz, Andrea Conrad, Christian Behl, Regina Hanstein, Christof Hiebel
Publikováno v:
Neurobiol Aging
Alzheimer's disease (AD) is characterized by amyloid-beta deposition in amyloid plaques, neurofibrillary tangles, inflammation, neuronal loss, and cognitive deficits. Cannabinoids display neuromodulatory and neuroprotective effects and affect memory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7571564e97b471311886d3c7790e383f
https://doi.org/10.1016/j.neurobiolaging.2013.05.027
https://doi.org/10.1016/j.neurobiolaging.2013.05.027
Autor:
Lilli Sester, Christian Behl, Markus Munder, Matthias Theobald, Björn Jacobi, Yagmur Bülbül, Johannes Windschmitt, Janine Tappe, Christof Hiebel
Publikováno v:
Blood. 132:3205-3205
Introduction Although the therapeutic armamentarium against multiple myeloma has tremendously increased in recent years, it still remains an incurable disease. A highly promising novel anti-tumoral treatment strategy is to target specific non-redunda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ff54809be036b0584393507bce9e173
https://doi.org/10.1182/blood-2018-99-113396
https://doi.org/10.1182/blood-2018-99-113396
Autor:
Christian Behl, Vanessa Felzen, Christof Hiebel, C Brandts, Donat Kögel, S Reißig, Tobias Morawe, Ingrid Koziollek-Drechsler, Uwe Wolfrum
Publikováno v:
Cell Death & Disease
Breast cancer is a heterogeneous disease and approximately 70% of newly diagnosed breast cancers are estrogen receptor (ER) positive. Out of the two ER types, α and β, ERα is the only ER that is detectable by immunohistochemistry in breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02dcfe78f7c30b2bb04a1bdd47e332ed
http://europepmc.org/articles/PMC4650728
http://europepmc.org/articles/PMC4650728