Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Christof Haffner"'
Autor:
Rebecca I. Sienel, Uta Mamrak, Janina Biller, Stefan Roth, Andreas Zellner, Tipparat Parakaw, Rayomand S. Khambata, Arthur Liesz, Christof Haffner, Amrita Ahluwalia, Burcu F. Seker, Nikolaus Plesnila
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Ischemic stroke is a major global health issue and characterized by acute vascular dysfunction and subsequent neuroinflammation. However, the relationship between these processes remains elusive. In the current study, we investigated whether
Externí odkaz:
https://doaj.org/article/cff1eeded54441de8fcfefccd3e1e390
Autor:
Andreas Zellner, Stephan A. Müller, Barbara Lindner, Nathalie Beaufort, Annemieke J. M. Rozemuller, Thomas Arzberger, Nils C. Gassen, Stefan F. Lichtenthaler, Bernhard Kuster, Christof Haffner, Martin Dichgans
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Cerebral amyloid angiopathy (CAA) is an age-related condition and a major cause of intracerebral hemorrhage and cognitive decline that shows close links with Alzheimer's disease (AD). CAA is characterized by the aggregation of amyloid-β (A
Externí odkaz:
https://doaj.org/article/c9875e2684434a7c93f45c1595fd3baa
Autor:
Christof Haffner
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Maintaining the homeostasis of proteins (proteostasis) by controlling their synthesis, folding and degradation is a central task of cells and tissues. The gradual decline of the capacity of the various proteostasis machineries, frequently in combinat
Externí odkaz:
https://doaj.org/article/ff0e6ac24b4c4fed8b57317a327ff5cb
Autor:
Juergen Bernhagen, Lydia Luya Yu, Quinte Braster, Martin Dichgans, Christof Haffner, Rainer Malik, Yaw Asare, Thomas A. Campbell-James, Carlos Silvestre-Roig, Omar El Bounkari, Natalie Ziesch, Melanie Schneider, Steffen Tiedt, Remco T. A. Megens, Arthur Liesz, Guangyao Yan, Kyra Thomas, Yishu Huang, Yury Bokov, Manuela Schneider, Matthias Prestel, Stefan Roth, Tobias Straub, Oliver Soehnlein
Publikováno v:
Circulation Research, 127(6), 811-823. LIPPINCOTT WILLIAMS & WILKINS
Rationale: Arterial inflammation manifested as atherosclerosis is the leading cause of mortality worldwide. Genome-wide association studies have identified a prominent role of HDAC (histone deacetylase)-9 in atherosclerosis and its clinical complicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6f040fc7988f5316f83355b3835630
https://doi.org/10.1161/circresaha.120.316743
https://doi.org/10.1161/circresaha.120.316743
Autor:
Michael Ehrmann, Nathalie Beaufort, Cathie Sudlow, Simon Frerich, Amy C Ferguson, Martin Dichgans, Christof Haffner, Marios K. Georgakis, Matthew Traylor, Rainer Malik, Benno Gesierich, Kristiina Rannikmäe
Publikováno v:
Brain 144(9), 2670-2682 (2021). doi:10.1093/brain/awab253
White matter hyperintensities (WMH) are among the most common radiological abnormalities in the ageing population and an established risk factor for stroke and dementia. While common variant association studies have revealed multiple genetic loci wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5b47de89c74f3f334ac1997221987b
https://pub.dzne.de/record/163194
https://pub.dzne.de/record/163194
Autor:
Christian Lüchtenborg, Giannis Maimaris, Antonis Ververis, Andri Makrigiorgi, Renos Georgiou, Andri Christodoulou, Niovi Santama, Christof Haffner, Carsten W. Lederer, Evelina Charidemou, Britta Brügger
Publikováno v:
Journal of Cell Science.
The structurally and functionally complex Endoplasmic Reticulum (ER) hosts critical processes including lipid synthesis. Here, we focus on the functional characterization of transmembrane protein TMEM147 and report that it localizes at the ER and nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d77e15eb137535fa256e03339d0b4fe
https://doi.org/10.1242/jcs.245357
https://doi.org/10.1242/jcs.245357
Autor:
Matthias, Prestel, Caroline, Prell-Schicker, Tom, Webb, Rainer, Malik, Barbara, Lindner, Natalie, Ziesch, Monika, Rex-Haffner, Simone, Röh, Thanatip, Viturawong, Manuel, Lehm, Michal, Mokry, Hester, den Ruijter, Saskia, Haitjema, Yaw, Asare, Flavia, Söllner, Maryam Ghaderi, Najafabadi, Rédouane, Aherrahrou, Mete, Civelek, Nilesh J, Samani, Matthias, Mann, Christof, Haffner, Martin, Dichgans
Publikováno v:
Stroke. 50(10)
Background and Purpose- Genome-wide association studies have identified the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::588dee4b97697d50b13d29968ebfa744
https://pubmed.ncbi.nlm.nih.gov/31500558
https://pubmed.ncbi.nlm.nih.gov/31500558
Autor:
Christof Haffner, Regina Fluhrer, Peter Krawitz, Harald Steiner, Bettina Schmid, Christian Haass
Signal peptide peptidase (SPP) is an unusual aspartyl protease that mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER). Like presenilins, which provide the proteolytically active subunit of the gamma-secretase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c706551180156deefcb8214dbb0f7c1
Autor:
Martin Dichgans, Rainer Malik, Nilesh J. Samani, Flavia Söllner, Tom R. Webb, Natalie Ziesch, Thanatip Viturawong, Monika Rex-Haffner, Manuel Lehm, Barbara Lindner, Mete Civelek, Michal Mokry, Maryam Ghaderi Najafabadi, Redouane Aherrahrou, Matthias Prestel, Simone Röh, Yaw Asare, Christof Haffner, Caroline Prell-Schicker, Hester M. den Ruijter, Saskia Haitjema, Matthias Mann
Publikováno v:
Stroke
Stroke, 50(10), 2651. Lippincott Williams and Wilkins
Stroke, 50(10), 2651. Lippincott Williams and Wilkins
Background and Purpose— Genome-wide association studies have identified the HDAC9 (histone deacetylase 9) gene region as a major risk locus for atherosclerotic stroke and coronary artery disease in humans. Previous results suggest a role of altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d5dfc99eec026aa47ad2eb6cf51bef
Autor:
Amin Ziaei, Xiaohong Xu, Leila Dehghani, Mahmoud A. Pouladi, Christof Haffner, Vahid Shaygannejad, Alvin Yu Jin Ng, Andreas Zellner, Bruno Reversade, Sumanty Tohari, Carine Bonnard, Byrappa Venkatesh
Publikováno v:
Neurology: Genetics, 5(4):345. Lippincott Williams and Wilkins
ObjectiveTo investigate the possible involvement of germline mutations in a neurologic condition involving diffuse white matter lesions.MethodsThe patients were 3 siblings born to healthy parents. We performed homozygosity mapping, whole-exome sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34545af889a4cb257eaa1e54dfb3f814
https://doi.org/10.1212/nxg.0000000000000345
https://doi.org/10.1212/nxg.0000000000000345