Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Christof Fellmann"'
Autor:
I-Li Tan, Alexendar R. Perez, Rachel J. Lew, Xiaoyu Sun, Alisha Baldwin, Yong K. Zhu, Mihir M. Shah, Mitchel S. Berger, Jennifer A. Doudna, Christof Fellmann
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113339- (2023)
Summary: Glioblastoma (GBM) is the most common lethal primary brain cancer in adults. Despite treatment regimens including surgical resection, radiotherapy, and temozolomide (TMZ) chemotherapy, growth of residual tumor leads to therapy resistance and
Externí odkaz:
https://doaj.org/article/d8685e6afe054325880742901e6d843a
Autor:
Arik Shams, Sean A. Higgins, Christof Fellmann, Thomas G. Laughlin, Benjamin L. Oakes, Rachel Lew, Shin Kim, Maria Lukarska, Madeline Arnold, Brett T. Staahl, Jennifer A. Doudna, David F. Savage
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Proteins evolve through the modular rearrangement of domains. Here the authors introduce MISER, a minimization by iterative size-exclusion and recombination method to make all possible deletions of a protein, uncovering functions for Cas9 domains inv
Externí odkaz:
https://doaj.org/article/f92b1a4bf0574fe9b95344d8bcec8e40
Autor:
Marco J. Lobba, Christof Fellmann, Alan M. Marmelstein, Johnathan C. Maza, Elijah N. Kissman, Stephanie A. Robinson, Brett T. Staahl, Cole Urnes, Rachel J. Lew, Casey S. Mogilevsky, Jennifer A. Doudna, Matthew B. Francis
Publikováno v:
ACS Central Science, Vol 6, Iss 9, Pp 1564-1571 (2020)
Externí odkaz:
https://doaj.org/article/717bb74132f54986ad0e5c0d11e24c37
Autor:
Kale Kundert, James E. Lucas, Kyle E. Watters, Christof Fellmann, Andrew H. Ng, Benjamin M. Heineike, Christina M. Fitzsimmons, Benjamin L. Oakes, Jiuxin Qu, Neha Prasad, Oren S. Rosenberg, David F. Savage, Hana El-Samad, Jennifer A. Doudna, Tanja Kortemme
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Control of CRISPR-Cas9 activity allows for fine-tuning of editing and gene expression. Here the authors use gRNAs modified with RNA aptamers to enable small molecule control in bacterial systems.
Externí odkaz:
https://doaj.org/article/75a198d8f2ba47a985055e98863b4ffd
Autor:
Hyo Min Park, Hui Liu, Joann Wu, Anthony Chong, Vanessa Mackley, Christof Fellmann, Anirudh Rao, Fuguo Jiang, Hunghao Chu, Niren Murthy, Kunwoo Lee
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Optimization of the recently discovered Class 2 CRISPR protein Cpf1 has the potential to promote its applications in gene editing and therapeutics. Here, the authors find that extending the 5′ end of the crRNA can increase both the editing efficien
Externí odkaz:
https://doaj.org/article/28c8eaacf2fc48ad8caaf32212f85d51
Autor:
Tina L. Yuan, Arnaud Amzallag, Rachel Bagni, Ming Yi, Shervin Afghani, William Burgan, Nicole Fer, Leslie A. Strathern, Katie Powell, Brian Smith, Andrew M. Waters, David Drubin, Ty Thomson, Rosy Liao, Patricia Greninger, Giovanna T. Stein, Ellen Murchie, Eliane Cortez, Regina K. Egan, Lauren Procter, Matthew Bess, Kwong Tai Cheng, Chih-Shia Lee, Liam Changwoo Lee, Christof Fellmann, Robert Stephens, Ji Luo, Scott W. Lowe, Cyril H. Benes, Frank McCormick
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1889-1902 (2018)
Summary: KRAS can bind numerous effector proteins, which activate different downstream signaling events. The best known are RAF, phosphatidylinositide (PI)-3′ kinase, and RalGDS families, but many additional direct and indirect effectors have been
Externí odkaz:
https://doaj.org/article/b9acf930ce7f49cbbf8886d56ca37592
Autor:
Gavin J Knott, Brady F Cress, Jun-Jie Liu, Brittney W Thornton, Rachel J Lew, Basem Al-Shayeb, Daniel J Rosenberg, Michal Hammel, Benjamin A Adler, Marco J Lobba, Michael Xu, Adam P Arkin, Christof Fellmann, Jennifer A Doudna
Publikováno v:
eLife, Vol 8 (2019)
CRISPR-Cas systems provide bacteria and archaea with programmable immunity against mobile genetic elements. Evolutionary pressure by CRISPR-Cas has driven bacteriophage to evolve small protein inhibitors, anti-CRISPRs (Acrs), that block Cas enzyme fu
Externí odkaz:
https://doaj.org/article/164dc30ebd294804bf4e661f484ab735
Autor:
Christof Fellmann, Thomas Hoffmann, Vaishali Sridhar, Barbara Hopfgartner, Matthias Muhar, Mareike Roth, Dan Yu Lai, Inês A.M. Barbosa, Jung Shick Kwon, Yuanzhe Guan, Nishi Sinha, Johannes Zuber
Publikováno v:
Cell Reports, Vol 5, Iss 6, Pp 1704-1713 (2013)
Short hairpin RNA (shRNA) technology enables stable and regulated gene repression. For establishing experimentally versatile RNAi tools and minimizing toxicities, synthetic shRNAs can be embedded into endogenous microRNA contexts. However, due to our
Externí odkaz:
https://doaj.org/article/989d8540a74d47cb99c674fb1963f415
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S2. Genetic tools used for dissecting Il6/Stat3/Myc signaling. (A) Scheme of conditional alleles and PCR primers used for assessing the recombination of Pten/ Trp53 genes. (B) Senescence-specific ß-gal staining is detected aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3752ff135b1299d84053c6e9105cff5a
https://doi.org/10.1158/2159-8290.22531532
https://doi.org/10.1158/2159-8290.22531532
Autor:
Lloyd C. Trotman, Brian D. Robinson, Carlos Cordon-Cardo, Mireia Castillo-Martin, John E. Wilkinson, Raffaella Sordella, Muhan Chen, David Kleinman, Tumas Beinortas, David Ding, Christof Fellmann, Serif Senturk, Victoria M.Y. Wang, Daniel V. DeMarco, Kaitlin Watrud, Tali Herzka, Hyejin Cho, Dawid G. Nowak
Supplementary Figure S1. Copy Number Alteration analysis of human prostate cancer confirms loss of PTEN and TP53 genes as a genetic hallmark of metastatic prostate cancer. (A) Co-deletion frequency for PTEN and TP53 in metastatic and primary prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e22326194e1055bee8ad81bfb6aeb82
https://doi.org/10.1158/2159-8290.22531538.v1
https://doi.org/10.1158/2159-8290.22531538.v1