Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Christof Dücker"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 161, Iss , Pp 114454- (2023)
The organic cation transporter 1 (OCT1) mediates the cell uptake and cytochrome P450 2D6 (CYP2D6) the metabolism of many cationic substrates. Activities of OCT1 and CYP2D6 are affected by enormous genetic variation and frequent drug-drug interactions
Externí odkaz:
https://doaj.org/article/97ea442760fe40ef942a7feb90aa3451
Autor:
Amin Polzin, Lisa Dannenberg, Carolin Helten, Martin Pöhl, Daniel Metzen, Philipp Mourikis, Christof Dücker, Ursula Marschall, Helmut L’Hoest, Beata Hennig, Saif Zako, Kajetan Trojovsky, Tobias Petzold, Christian Jung, Bodo Levkau, Tobias Zeus, Karsten Schrör, Thomas Hohlfeld, Malte Kelm
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
Background Pain is a major issue in our aging society. Dipyrone (metamizole) is one of the most frequently used analgesics. Additionally, it has been shown to impair pharmacodynamic response to aspirin as measured by platelet function tests. However,
Externí odkaz:
https://doaj.org/article/46863831286544e9afcf8e597f1baae2
Autor:
David A. Doetsch, Salim Ansari, Ole Jensen, Lukas Gebauer, Christof Dücker, Jürgen Brockmöller, Alexandra Sachkova
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8430 (2022)
Many organic cations (OCs) may be transported through membranes by a genetically still uncharacterized proton-organic cation (H + OC) antiporter. Here, we characterized an extended substrate spectrum of this antiporter. We studied the uptake of 72 dr
Externí odkaz:
https://doaj.org/article/44d03a538c3348d984624174864b051f
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2007 (2022)
The organic cation transporter 1 (OCT1, SLC22A1) transports a large number of structurally diverse endogenous and exogenous substrates. There are numerous known competitive and non-competitive inhibitors of OCT1, but there are no studies systematical
Externí odkaz:
https://doaj.org/article/1ae4b118b0834f209ef494aa7ba7896c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12816 (2021)
Human monoamine transporters (MATs) are cation transporters critically involved in neuronal signal transmission. While inhibitors of MATs have been intensively studied, their substrate spectra have received far less attention. Polyspecific organic ca
Externí odkaz:
https://doaj.org/article/b71d70ad488e4760928add29a5d62763
Publikováno v:
Journal of Medicinal Chemistry. 65:12403-12416
Organic cation transporters (OCTs) 1, 2, and 3 facilitate cellular uptake of structurally diverse endogenous and exogenous substances. However, their substrate and inhibitor specificity are not fully understood. We performed a broad
Autor:
Amin, Polzin, Lisa, Dannenberg, Carolin, Helten, Martin, Pöhl, Daniel, Metzen, Philipp, Mourikis, Christof, Dücker, Ursula, Marschall, Helmut, L'Hoest, Beata, Hennig, Saif, Zako, Kajetan, Trojovsky, Tobias, Petzold, Christian, Jung, Bodo, Levkau, Tobias, Zeus, Karsten, Schrör, Thomas, Hohlfeld, Malte, Kelm
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Pain is a major issue in our aging society. Dipyrone (metamizole) is one of the most frequently used analgesics. Additionally, it has been shown to impair pharmacodynamic response to aspirin as measured by platelet function tests. However,
Publikováno v:
Pharmacology & Therapeutics. 239:108283
About 30% of all small molecular drugs are organic cations (OCs). If these are more or less hydrophilic, they require membrane transporters to pass through biological membranes. Here, the proton-organic cation (Hsup+/supOC) antiporter may play a phys
Publikováno v:
Journal of medicinal chemistry. 64(5)
OCT1 is the most highly expressed cation transporter in the liver and affects pharmacokinetics and pharmacodynamics. Newly marketed drugs have previously been screened as potential OCT1 substrates and verified by virtual docking. Here, we used machin
Autor:
Martin Pöhl, Christof Dücker, Ursula Marschall, Helmut L'Hoest, Kajetan Trojovsky, Amin Polzin, Thomas Hohlfeld, Karsten Schrör, Beata Hennig, Carolin Helten, Saif Zako, Christian Jung, Malte Kelm, Tobias Zeus, Daniel Metzen, Philipp Mourikis, Lisa Dannenberg, Bodo Levkau, Tobias Petzold
Publikováno v:
SSRN Electronic Journal.
Background: Acute and chronic pain is a major issue in aging society. Dipyrone (metamizole, novalgin) is one of the most frequently used analgesics in many countries, despite that it may cause agranulocytosis. Additionally, it has recently been shown