Ribonucleoprotein particles containing non-coding Y RNAs, Ro60, La and nucleolin are not required for Y RNA function in DNA replication.

Autor: Alexander R Langley, Helen Chambers, Christo P Christov, Torsten Krude

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13673 (2010)

Ro ribonucleoprotein particles (Ro RNPs) consist of a non-coding Y RNA bound by Ro60, La and possibly other proteins. The physiological function of Ro RNPs is controversial as divergent functions have been reported for its different constituents. We

Externí odkaz: https://doaj.org/article/bc7e1360bc384466b674fd1d317c233c

Effects of Mutations on Structure–Function Relationships of Matrix Metalloproteinase-1

Autor: Warispreet Singh, Gregg B. Fields, Christo Z. Christov, Tatyana G. Karabencheva-Christova

Publikováno v: International Journal of Molecular Sciences, Vol 17, Iss 10, p 1727 (2016)

Matrix metalloproteinase-1 (MMP-1) is one of the most widely studied enzymes involved in collagen degradation. Mutations of specific residues in the MMP-1 hemopexin-like (HPX) domain have been shown to modulate activity of the MMP-1 catalytic (CAT) d

Externí odkaz: https://doaj.org/article/0860f3e445d54a5f87738f84414fded6

Neuronal Control of Metabolism through Nutrient-Dependent Modulation of Tracheal Branching

Autor: Gerit A. Linneweber, Tomoki Otani, Bruno Hudry, Michaela Yuan, Elisabeth Knust, Irene Miguel-Aliaga, Mario de Bono, Jake Jacobson, Dirk Dormann, Christo P. Christov, Karl Emanuel Busch

Publikováno v: Cell
Linneweber, G A, Jacobson, J, Busch, K E, Hudry, B, Christov, C P, Dormann, D, Yuan, M, Otani, T, Knust, E, de Bono, M & Miguel-Aliaga, I 2014, ' Neuronal Control of Metabolism through Nutrient-Dependent Modulation of Tracheal Branching ', Cell, vol. 156, no. 1-2, pp. 69-83 . https://doi.org/10.1016/j.cell.2013.12.008

Summary During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cfb318d18d56c04d88034f4c76b1b2
http://europepmc.org/articles/PMC3898607

Conserved Mechanisms of Tumorigenesis in the Drosophila Adult Midgut

Autor: Christo P. Christov, Kyra Campbell, Irene Miguel-Aliaga, Anna Merlos-Suárez, Jordi Casanova, Eduard Batlle, Francisco M. Barriga, Andreu Casali, Òscar Martorell

Publikováno v: PLoS ONE
Digital.CSIC. Repositorio Institucional del CSIC
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PLoS ONE, Vol 9, Iss 2, p e88413 (2014)

Whereas the series of genetic events leading to colorectal cancer (CRC) have been well established, the precise functions that these alterations play in tumor progression and how they disrupt intestinal homeostasis remain poorly characterized. Activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d932422798bbaf59a53edb428839d4

The midblastula transition defines the onset of Y RNA-dependent DNA replication in Xenopus laevis

Autor: Clara Collart, Torsten Krude, Christo P. Christov, James C. Smith

Publikováno v: Molecular and cellular biology. 31(18)

Noncoding Y RNAs are essential for the initiation of chromosomal DNA replication in mammalian cell extracts, but their role in this process during early vertebrate development is unknown. Here, we use antisense morpholino nucleotides (MOs) to investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842bd9e6019d775f4fa7f36da48a9879
https://pubmed.ncbi.nlm.nih.gov/21791613