Výsledky vyhledávání - "Christine Zouki"

Lipoxin A 4 and aspirin-triggered 15-epi-lipoxin A 4 inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes

Autor: Charles N. Serhan, János G. Filep, Christine Zouki, Levente Jozsef, Nicos A. Petasis

Publikováno v: Proceedings of the National Academy of Sciences. 99:13266-13271

Lipoxin A 4 (LXA 4 ) and aspirin-triggered 15-epi-LXA 4 (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury. Recent studies indicate that peroxynitrite (ONOO − ) may function as an intracellular signal for the pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3807c2bccae39d59258d6fcd6bb642b
https://doi.org/10.1073/pnas.202296999

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Methods for analysis of matrix metalloproteinase regulation of neutrophil-endothelial cell adhesion

Autor: Sandra T. Davidge, Carlos Fernandez-Patron, János G. Filep, Randy M. Whittal, John S.D. Chan, Christine Zouki

Publikováno v: Biological Procedures
Biological Procedures Online, Vol 4, Iss 1, Pp 38-48 (2002)

Recent evidence indicates novel role for matrix metalloproteinases (MMPs), in particular gelatinase A (MMP-2), in the regulation of vascular biology that are unrelated to their well-known proteolytic breakdown of matrix proteins. We have previously r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d3315fa6ada0ca8b019803879feb7e
https://doi.org/10.1251/bpo32

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Matrix metalloproteinases regulate neutrophil‐endothelial cell adhesion through generation of endothelin‐1[1–32]

Autor: John S.D. Chan, Sandra T. Davidge, János G. Filep, Randy M. Whittal, Christine Zouki, Carlos Fernandez-Patron

Publikováno v: The FASEB Journal. 15:2230-2240

We recently reported that matrix metalloproteinase 2 (MMP-2, gelatinase A) cleaves big endothelin 1 (ET-1), yielding the vasoactive peptide ET-1[1-32]. We tested whether ET-1[1-32] could affect the adhesion of human neutrophils to coronary artery end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea845e8772d76911c396f828254c0095
https://doi.org/10.1096/fj.01-0178com

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Peroxynitrite mediates cytokine-induced IL-8 gene expression and production by human leukocytes

Autor: Sophie Ouellet, Yves Paquette, Levente Jozsef, Christine Zouki, János G. Filep

Publikováno v: Journal of Leukocyte Biology. 69:815-824

Recent studies indicate that nitric oxide (NO) or related compounds may regulate the production of interleukin (IL)-8, a potent proinflammatory chemokine. Here we report that peroxynitrite (ONOO(-)) formed by a reaction of NO with superoxide mediates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453fc65d8d57f17a6a2bbe77096170e4
https://doi.org/10.1189/jlb.69.5.815

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The anti‐inflammatory peptides, antiflammins, regulate the expression of adhesion molecules on human leukocytes and prevent neutrophil adhesion to endothelial cells

Autor: Sophie Ouellet, Christine Zouki, János G. Filep

Publikováno v: The FASEB Journal. 14:572-580

Antiflammin-1 and antiflammin-2 are nonapeptides corresponding to the region of highest similarity between glucocorticoid-inducible proteins lipocortin-1 and uteroglobin. We have studied whether antiflammins could affect expression of adhesion molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78b40a2401d590fc3fe06802160bc09
https://doi.org/10.1096/fasebj.14.3.572

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Anti-Inflammatory Actions of Lipoxin A4 Stable Analogs Are Demonstrable in Human Whole Blood: Modulation of Leukocyte Adhesion Molecules and Inhibition of Neutrophil-Endothelial Interactions

Autor: Charles N. Serhan, Nicos A. Petasis, Mohamed Hachicha, Christine Zouki, János G. Filep

Publikováno v: Blood. 94:4132-4142

We have examined in whole blood the actions of 2 lipoxin A4 (LXA4) stable analogs, 15-R/S-methyl-LXA4 and 16-phenoxy-LXA4, for their impact on the expression of adhesion molecules on human leukocytes and coronary artery endothelial cells (HCAEC) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1455cd4d9ddd8d37b111d50d92595930
https://doi.org/10.1182/blood.v94.12.4132

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Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ETAreceptors and platelet-activating factor

Autor: Chantal Baron, Alain Fournier, János G. Filep, Christine Zouki

Publikováno v: British Journal of Pharmacology. 127:969-979

1. The potent coronary vasoconstrictor, endothelin-1 (ET-1) may also regulate neutrophil traffic into tissues. The aim of the present study was to characterize the endothelin receptors responsible and to investigate the underlying mechanisms. 2. ET-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e69a958521ef250f4939d62385f74e3a
https://doi.org/10.1038/sj.bjp.0702593

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A simplified approach to predict CYP3A-mediated drug-drug interactions at early drug discovery: validation with clinical data

Autor: Jianmin Duan, Richard Bethell, Maria D. Ribadeneira, Jonathan Massé, Nathalie Rioux, Federico Colombo, Joëlle Batonga, Christine Zouki

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 43(7)

1. The present study evaluates which factors should be incorporated into a simplified approach to reasonably predict CYP3A-mediated drug-drug interaction (DDI) at an early drug discovery stage. 2. CYP3A IC50 values were obtained using human liver mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56284e4c3b16100081f5b0d4409de838
https://pubmed.ncbi.nlm.nih.gov/23244592

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Peroxynitrite induces integrin‐dependent adhesion of human neutrophils to endothelial cells via activation of the Raf‐1/MEK/Erk pathway

Autor: János G. Filep, Christine Zouki, Shao-Ling Zhang, John S.D. Chan

Publikováno v: The FASEB Journal. 15:25-27

Accumulating evidence suggests that enhanced peroxynitrite (ONOO-) formation occurs during inflammation. We have studied the impact and the mechanisms of ONOO- action on expression of adhesion molecules on human neutrophils and coronary artery endoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e5fd3d2976e1a53855360450599c11
https://doi.org/10.1096/fj.00-0521fje

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