Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christine Y. Ivashchenko"'
Publikováno v:
PPAR Research, Vol 2008 (2008)
Peroxisome proliferator-activated receptor-γ (PPAR-γ), an essential transcriptional mediator of adipogenesis, lipid metabolism, insulin sensitivity, and glucose homeostasis, is increasingly recognized as a key player in inflammatory cells and in ca
Externí odkaz:
https://doaj.org/article/1d17facecbf545f5b1612992b11c4aa3
Autor:
Christine Y. Ivashchenko
Publikováno v:
Recent Patents on Cardiovascular Drug Discovery. 6:199-206
Human embryonic stem cells, hES, and the recently created human induced pluripotent stem cells, hiPS, have a multitude of uses in cardiovascular drug discovery with a significant patent coverage for most applications. The research involving hiPS and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806f21dd9485f9362ae11af01c77688d
https://doi.org/10.2174/157489011797377077
https://doi.org/10.2174/157489011797377077
Autor:
Benjamin T. Bradley, James Leiper, Zhaohui Ao, Patrick Vallance, Douglas G. Johns, Christine Y. Ivashchenko
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 298:H251-H258
Asymmetric dimethylarginine (ADMA) has been implicated in the progression of cardiovascular disease as an endogenous inhibitor of nitric oxide synthase. The regulation of dimethylarginine dimethylaminohydrolase (DDAH), the enzyme responsible for meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6046e6c159bde405562942d61dc5b1
https://doi.org/10.1152/ajpheart.00195.2009
https://doi.org/10.1152/ajpheart.00195.2009
Publikováno v:
PPAR Research, Vol 2008 (2008)
Peroxisome proliferator-activated receptor-γ(PPAR-γ), an essential transcriptional mediator of adipogenesis, lipid metabolism, insulin sensitivity, and glucose homeostasis, is increasingly recognized as a key player in inflammatory cells and in car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87032ddec3c80382b08d06deed10686b
https://doi.org/10.1155/2008/745804
https://doi.org/10.1155/2008/745804
Autor:
Louis G. D'Alecy, Richard M. Mortensen, Steven E. Whitesall, Christine Y. Ivashchenko, Sheng-Zhong Duan
Publikováno v:
Physiological Measurement. 28:1329-1339
Pressure overload (POL) is a classical model for studying cardiac hypertrophy, but there has been no direct measure of hemodynamics in a conscious ambulatory mouse model of POL. We used abdominal aortic constriction to produce POL and radiotelemetry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48275e6ad03af4d55d8700fe037af64
https://doi.org/10.1088/0967-3334/28/11/001
https://doi.org/10.1088/0967-3334/28/11/001
Autor:
Melissa A. Pierre, Damon Duquaine, Louis G. D'Alecy, Charles Vinson, Richard M. Mortensen, Frank C. Brosius, Steven E. Whitesall, David S. Milstone, Frank J. Gonzalez, Christine Y. Ivashchenko, Sheng-Zhong Duan
Publikováno v:
Journal of Clinical Investigation. 117:812-822
We rescued the embryonic lethality of global PPARgamma knockout by breeding Mox2-Cre (MORE) mice with floxed PPARgamma mice to inactivate PPARgamma in the embryo but not in trophoblasts and created a generalized PPARgamma knockout mouse model, MORE-P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4800ec1ae260a1536081544f9b9223c5
https://doi.org/10.1172/jci28859
https://doi.org/10.1172/jci28859
Autor:
Richard M. Mortensen, David S. Milstone, Sheng-Zhong Duan, Mark W. Russell, Christine Y. Ivashchenko
Publikováno v:
Circulation Research. 97:372-379
Peroxisome proliferator-activated receptor (PPAR)-gamma is required for adipogenesis but is also found in the cardiovascular system, where it has been proposed to oppose inflammatory pathways and act as a growth suppressor. PPAR-gamma agonists, thiaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cde5bd1161913aec5a47f855003d5d9
https://doi.org/10.1161/01.res.0000179226.34112.6d
https://doi.org/10.1161/01.res.0000179226.34112.6d
Autor:
John R. Toomey, Eugene T. Grygielko, John J. Lepore, Zuojun Lin, Saul Needle, Erding Hu, Gordon C. Teg Pipes, Irina M. Lozinskaya, Christine Y. Ivashchenko, Xu Xiaoping, Robert N. Willette
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 305(6)
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) have been recently derived and are used for basic research, cardiotoxicity assessment, and phenotypic screening. However, the hiPS-CM phenotype is dependent on their derivation, ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcf66c81cf63f4f12ecb74a266da51c
https://pubmed.ncbi.nlm.nih.gov/23832699
https://pubmed.ncbi.nlm.nih.gov/23832699
Publikováno v:
PPAR Research
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), an essential transcriptional mediator of adipogenesis, lipid metabolism, insulin sensitivity, and glucose homeostasis, is increasingly recognized as a key player in inflammatory cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72fed057e767e86d0a3cc7ac63cd06db
https://pubmed.ncbi.nlm.nih.gov/18288291
https://pubmed.ncbi.nlm.nih.gov/18288291
Autor:
Sheng Zhong, Christine Y Ivashchenko, Steven E Whitesall, Louis G D, Alecy and, Richard M Mortensen
Publikováno v:
Physiological Measurement; Nov2007, Vol. 28 Issue 11, p1329-1339, 11p