Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christine Xing'Er Koo"'
Autor:
Zenjiro Sampei, Christine Xing’er Koo, Frannie Jiuyi Teo, Ying Xiu Toh, Taku Fukuzawa, Siok Wan Gan, Takeru Nambu, Adrian Ho, Kiyofumi Honda, Tomoyuki Igawa, Fariyal Ahmed, Cheng-I Wang, Katja Fink, Junichi Nezu
Publikováno v:
Antibodies, Vol 12, Iss 2, p 36 (2023)
To combat infectious diseases, vaccines are considered the best prophylactic strategy for a wide range of the population, but even when vaccines are effective, the administration of therapeutic antibodies against viruses could provide further treatme
Externí odkaz:
https://doaj.org/article/a2953071e1654c75af8815c87546bdba
Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells
Autor:
Yu J. Shen, Nina Le Bert, Anuja A. Chitre, Christine Xing’Er Koo, Xing H. Nga, Samantha S.W. Ho, Muznah Khatoo, Nikki Y. Tan, Ken J. Ishii, Stephan Gasser
Publikováno v:
Cell Reports, Vol 11, Iss 3, Pp 460-473 (2015)
The DNA damage response (DDR) induces the expression of type I interferons (IFNs), but the underlying mechanisms are poorly understood. Here, we show the presence of cytosolic DNA in different mouse and human tumor cells. Treatment of cells with geno
Externí odkaz:
https://doaj.org/article/b64878490de44c35adf2fa2aec76582d
Autor:
Tomohiro Kanuma, Takato Kusakabe, Kouji Kobiyama, Taiki Aoshi, Kenji Kabashima, Takahiro Nagatake, Burcu Temizoz, Christine Xing’Er Koo, Shingo Kobari, Etsushi Kuroda, Masayuki Hayashi, Koji Ozasa, Steven F. Ziegler, Ken Ishii, Tomohiro Kurosaki, Wataru Ise, Naoki Takemura, Satoshi Uematsu, Keiichi Ohata, Cevayir Coban, Yasuo Morimoto, Yoichiro Iwakura, Saeko Nakajima, Jun Kunisawa, Masanori Horie
Publikováno v:
Immunity. 45:1299-1310
Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a0200df0f9e9e6193887a238692d6a
https://doi.org/10.1016/j.immuni.2016.11.010
https://doi.org/10.1016/j.immuni.2016.11.010
Autor:
Muznah Khatoo, Samantha S.W. Ho, Florence S.G. Cheung, Nikki Y. Tan, Yu J. Shen, Stephan Gasser, Christine Xing’Er Koo
Publikováno v:
Cytokine. 76(2)
We recently provided evidence that genome-derived DNA is present in the cytosol of many tumor cells. Genomic loci that give rise to cytosolic DNA can potentially form non-B DNA structures including triple-stranded RNA:DNA structures (R-loops). The RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc02abe41dbff6413c47d674162c2bcf
https://pubmed.ncbi.nlm.nih.gov/26070935
https://pubmed.ncbi.nlm.nih.gov/26070935
Autor:
Yu J. Shen, Nina LeBert, Ken Ishii, Shandar Ahmad, Christine Xing’Er Koo, Taiki Aoshi, Stephan Gasser, Muznah Khatoo, Kouji Kobiyama
Publikováno v:
The Journal of Biological Chemistry
Background: RNA:DNA hybrids exist in the nucleus and mitochondria but not in the cytosol, except in viral infection. Results: RNA:DNA hybrids exist in the cytosol of various human cells and are mediated by RNA polymerase III (Pol III), which regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0044f7de4131927dd7dd2b4c8fa0778d
https://pubmed.ncbi.nlm.nih.gov/25623070
https://pubmed.ncbi.nlm.nih.gov/25623070
RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma
Autor:
Li F. M. Tang, John Ludovic Croxford, Yu J. Shen, Stephan Gasser, Nina Le Bert, Shizuo Akira, Christine Xing’Er Koo, Samantha S.W. Ho, Gordon Minru Xiong, Adeline R. Lam, David H. Raulet, Ken Ishii
Publikováno v:
Lam, AR; Bert, NL; Ho, SSW; Shen, YJ; Tang, MLF; Xiong, GM; et al.(2014). RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma. Cancer Research, 74(8), 2193-2203. doi: 10.1158/0008-5472.CAN-13-1703. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/7n26z2hx
Cancer research, vol 74, iss 8
Cancer research, vol 74, iss 8
The immunoreceptor NKG2D originally identified in natural killer (NK) cells recognizes ligands that are upregulated on tumor cells. Expression of NKG2D ligands (NKG2DL) is induced by the DNA damage response (DDR), which is often activated constitutiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a23dc0d58ecc330051eb9fcb9b393e
http://www.escholarship.org/uc/item/7n26z2hx
http://www.escholarship.org/uc/item/7n26z2hx
Toll-like receptors, NOD-like receptors and numerous intracellular sensors that detect nucleotides in the cytosol help to initiate immune responses to viral infections. Many of the cytosolic nucleotide sensors and their downstream mediators also play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c335775175eee587b29d9fd5c5b77e2
https://doi.org/10.1016/b978-0-12-404732-7.00009-5
https://doi.org/10.1016/b978-0-12-404732-7.00009-5
Autor:
Ken Ishii, David H. Raulet, Ho S. Samantha, Stephan Gasser, Yu J. Shen, Nina Le Bert, Christine Xing’Er Koo
Publikováno v:
Cancer Research. 74:3168-3168
Type I interferons (IFNs) are secreted by infected cells in response to the recognition of nucleic acids. DNA damage and the ensuing DNA damage response also induce the expression of IFNs by poorly understood mechanisms. Here we show the presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1951b51bedc7c6e30e23fd241f14e29b
https://doi.org/10.1158/1538-7445.am2014-3168
https://doi.org/10.1158/1538-7445.am2014-3168