Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE)

Autor: Frank Jessen, Annika Spottke, Henning Boecker, Frederic Brosseron, Katharina Buerger, Cihan Catak, Klaus Fliessbach, Christiana Franke, Manuel Fuentes, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Felix Menne, Peter Nestor, Oliver Peters, Josef Priller, Verena Pross, Alfredo Ramirez, Anja Schneider, Oliver Speck, Eike Jakob Spruth, Stefan Teipel, Ruth Vukovich, Christine Westerteicher, Jens Wiltfang, Steffen Wolfsgruber, Michael Wagner, Emrah Düzel

Publikováno v: Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-10 (2018)

Abstract Background Deep phenotyping and longitudinal assessment of predementia at-risk states of Alzheimer’s disease (AD) are required to define populations and outcomes for dementia prevention trials. Subjective cognitive decline (SCD) is a pre-m

Externí odkaz: https://doaj.org/article/9e9e6a38bf2a457799c223f02cc22638

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease

Autor: Nick C. Fox, Claudia Bartels, Henning Boecker, Peter R. Schofield, Stefan J. Teipel, Josef Priller, Peter Falkai, Michael Ewers, Michael T. Heneka, Stephen Salloway, Coraline D. Metzger, Jae-Hong Lee, Alfredo Ramirez, Michel J. Grothe, Anja Schneider, Colin L. Masters, Nicolai Franzmeier, Igor Yakushev, Oliver Peters, Eric McDade, Johannes Levin, Christoph Laske, Daniel Bittner, Agustín Ruiz, Michael Wagner, Gemma Monté-Rubio, Sonia Moreno-Grau, Miguel Ángel Araque Caballero, Felix Menne, Jason Hassenstab, Yen Ying Lim, Jens Wiltfang, Christian Haass, Anne M. Fagan, Frank Jessen, Marc Suárez-Calvet, Eike Jakob Spruth, Alison Goate, Adrian Danek, Manuel Fuentes, Octavio Rodríguez Gómez, Esther Milz, Christiana Franke, Brian A. Gordon, Robert Perneczky, Martin Dichgans, Martin N. Rossor, Klaus Fliessbach, Marco Duering, Tammie L.S. Benzinger, Celeste M. Karch, Peter J. Nestor, Frederic Brosseron, Jasmeer P. Chhatwal, Cihan Catak, Christine Westerteicher, Daniel Janowitz, Ingo Kilimann, Oliver Speck, Jinyi Ren, Katharina Buerger, Randall J. Bateman, Mercè Boada, Alexander Damm, Steffen Wolfsgruber, John C. Morris, Annika Spottke, Emrah Düzel

Publikováno v: Molecular psychiatry
Molecular psychiatry 26(2), 614-628 (2021). doi:10.1038/s41380-019-0404-6
Franzmeier, N, Ren, J, Damm, A, Monté-rubio, G, Boada, M, Ruiz, A, Ramirez, A, Jessen, F, Düzel, E, Rodríguez Gómez, O, Benzinger, T, Goate, A, Karch, C M, Fagan, A M, Mcdade, E, Buerger, K, Levin, J, Duering, M, Dichgans, M, Suárez-calvet, M, Haass, C, Gordon, B A, Lim, Y Y, Masters, C L, Janowitz, D, Catak, C, Wolfsgruber, S, Wagner, M, Milz, E, Moreno-grau, S, Teipel, S, Grothe, M J, Kilimann, I, Rossor, M, Fox, N, Laske, C, Chhatwal, J, Falkai, P, Perneczky, R, Lee, J, Spottke, A, Boecker, H, Brosseron, F, Fliessbach, K, Heneka, M T, Nestor, P, Peters, O, Fuentes, M, Menne, F, Priller, J, Spruth, E J, Franke, C, Schneider, A, Westerteicher, C, Speck, O, Wiltfang, J, Bartels, C, Araque Caballero, M Á, Metzger, C, Bittner, D, Salloway, S, Danek, A, Hassenstab, J, Yakushev, I, Schofield, P R, Morris, J C, Bateman, R J & Ewers, M 2019, ' The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease ', Molecular Psychiatry . https://doi.org/10.1038/s41380-019-0404-6

In Alzheimer's disease (AD), a single-nucleotide polymorphism in the gene encoding brain-derived neurotrophic factor (BDNFVal66Met) is associated with worse impact of primary AD pathology (beta-amyloid, Aβ) on neurodegeneration and cognitive decline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50ea03cf483f58c8dc9e6451ee25001
http://europepmc.org/articles/PMC6754794

Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer’s disease (DELCODE)

Autor: Klaus Fliessbach, Annika Spottke, Emrah Düzel, Eike Jakob Spruth, Frank Jessen, Steffen Wolfsgruber, Verena Pross, Oliver Speck, Michael Wagner, Alfredo Ramirez, Katharina Buerger, Oliver Peters, Ingo Kilimann, Jens Wiltfang, Josef Priller, Ruth Vukovich, Henning Boecker, Christoph Laske, Manuel Fuentes, Felix Menne, Cihan Catak, Frederic Brosseron, Michael T. Heneka, Stefan J. Teipel, Daniel Janowitz, Peter J. Nestor, Anja Schneider, Christiana Franke, Christine Westerteicher

Publikováno v: Jessen, F, Spottke, A, Boecker, H, Brosseron, F, Buerger, K, Catak, C, Fliessbach, K, Franke, C, Fuentes, M, Heneka, M T, Janowitz, D, Kilimann, I, Laske, C, Menne, F, Nestor, P, Peters, O, Priller, J, Pross, V, Ramirez, A, Schneider, A, Speck, O, Spruth, E J, Teipel, S, Vukovich, R, Westerteicher, C, Wiltfang, J, Wolfsgruber, S, Wagner, M & Düzel, E 2018, ' Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE) ', Alzheimer's research & therapy, vol. 10, no. 1, pp. 15 . https://doi.org/10.1186/s13195-017-0314-2
Alzheimer's Research & Therapy
Alzheimer's research & therapy 10(1), 15 (2018). doi:10.1186/s13195-017-0314-2
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-10 (2018)

Background Deep phenotyping and longitudinal assessment of predementia at-risk states of Alzheimer’s disease (AD) are required to define populations and outcomes for dementia prevention trials. Subjective cognitive decline (SCD) is a pre-mild cogni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc95966e2aa41933b48bf1afc9d3d3d9
https://doi.org/10.17169/refubium-24393

Clinical and neurobiological correlates of soluble amyloid precursor proteins in the cerebrospinal fluid

Autor: Timo Grimmer, Maria Rosaria Leante, Panagiotis Alexopoulos, Christine Westerteicher, Anila Arnold, Alexander Kurz, Amalia Tsolakidou, Robert Perneczky, Paolo Livrea, Hans Förstl, Francesco Roselli

Publikováno v: Alzheimer's & Dementia. 8:304-311

Background According to a widely accepted hypothesis, the amyloid precursor protein (APP) is processed by two competing pathways: the amyloidogenic β-secretase–mediated pathway or the nonamyloidogenic α-secretase–mediated pathway. APP is cleave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63992d9861482f1bd8c6c7afaf27b228
https://doi.org/10.1016/j.jalz.2011.04.009

Interrelations between CSF soluble AβPPβ, amyloid-β 1-42, SORL1, and tau levels in Alzheimer's disease

Autor: Robert Perneczky, Janine Diehl-Schmid, Alexander Kurz, Timo Grimmer, Amalia Tsolakidou, Panagiotis Alexopoulos, Christine Westerteicher, Hideaki Bujo, Liang-Hao Guo, Martina Kratzer, Meizi Jiang

Publikováno v: Journal of Alzheimer's disease : JAD. 28(3)

Recently, light has been shed on possible interrelations between the two most important pathological hallmarks of Alzheimer's disease (AD): the amyloid cascade and axonal degeneration. In this study, we investigated associations between sβAPPβ, a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9807022e8426d4072fd4c65eff2caa54
https://pubmed.ncbi.nlm.nih.gov/22045485