Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Christine Wegler"'
Autor:
Niklas Handin, Di Yuan, Magnus Ölander, Christine Wegler, Cecilia Karlsson, Rasmus Jansson-Löfmark, Jøran Hjelmesæth, Anders Åsberg, Volker M. Lauschke, Per Artursson
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4361-4369 (2023)
Human liver tissue is composed of heterogeneous mixtures of different cell types and their cellular stoichiometry can provide information on hepatic physiology and disease progression. Deconvolution algorithms for the identification of cell types and
Externí odkaz:
https://doaj.org/article/398158ee84d44ea5b316e13587231791
Autor:
Kine Eide Kvitne, Anders Åsberg, Line K. Johnson, Christine Wegler, Jens K. Hertel, Per Artursson, Cecilia Karlsson, Shalini Andersson, Rune Sandbu, Eva Skovlund, Hege Christensen, Rasmus Jansson‐Löfmark, Jøran Hjelmesæth, Ida Robertsen
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 11, Pp 2685-2696 (2022)
Abstract Previous studies have not accounted for the close link between type 2 diabetes mellitus (T2DM) and obesity when investigating the impact of T2DM on cytochrome P450 (CYP) activities. The aim was to investigate the effect of T2DM on in vivo ac
Externí odkaz:
https://doaj.org/article/1f0c72378b57453fa0275240cbd18d14
Autor:
Kine Eide Kvitne, Ida Robertsen, Eva Skovlund, Hege Christensen, Veronica Krogstad, Christine Wegler, Philip Carlo Angeles, Birgit Malene Wollmann, Kristine Hole, Line Kristin Johnson, Rune Sandbu, Per Artursson, Cecilia Karlsson, Shalini Andersson, Tommy B. Andersson, Jøran Hjelmesæth, Rasmus Jansson‐Löfmark, Anders Åsberg
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 221-233 (2022)
Abstract It remains uncertain whether pharmacokinetic changes following Roux‐en‐Y gastric bypass (RYGB) can be attributed to surgery‐induced gastrointestinal alterations per se and/or the subsequent weight loss. The aim was to compare short‐
Externí odkaz:
https://doaj.org/article/94c01bed522b40c5b3bb33a9c5738373
Autor:
Laura Hellinen, Ali Koskela, Elina Vattulainen, Mikko Liukkonen, Christine Wegler, Andrea Treyer, Niklas Handin, Richard Svensson, Timo Myöhänen, Antti Poso, Kai Kaarniranta, Per Artursson, Arto Urtti
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112501- (2022)
Dry age-related macular degeneration (AMD) is a currently untreatable vision threatening disease. Impaired proteasomal clearance and autophagy in the retinal pigment epithelium (RPE) and subsequent photoreceptor damage are connected with dry AMD, but
Externí odkaz:
https://doaj.org/article/ff9ee91632444222beb7327553911625
Autor:
Kine Eide Kvitne, Kristine Hole, Veronica Krogstad, Birgit Malene Wollmann, Christine Wegler, Line K. Johnson, Jens K. Hertel, Per Artursson, Cecilia Karlsson, Shalini Andersson, Tommy B. Andersson, Rune Sandbu, Jøran Hjelmesæth, Eva Skovlund, Hege Christensen, Rasmus Jansson-Löfmark, Anders Åsberg, Espen Molden, Ida Robertsen
Publikováno v:
European Journal of Clinical Pharmacology
1289–1299
1289–1299
Purpose Variability in cytochrome P450 3A4 (CYP3A4) metabolism is mainly caused by non-genetic factors, hence providing a need for accurate phenotype biomarkers. Although 4β-hydroxycholesterol (4βOHC) is a promising endogenous CYP3A4 biomarker, add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b5a692e754f48f8824d67a5bcd8e5b
https://doi.org/10.1007/s00228-022-03336-9
https://doi.org/10.1007/s00228-022-03336-9
Autor:
Charlène Cornilleau, Laura Alvarez, Christine Wegler, Cyrille Billaudeau, Felipe Cava, Rut Carballido-López
Publikováno v:
bioRxiv
Most bacteria are encased into a load-bearing rigid framework, the cell wall (CW). The peptidoglycan (PG) layer, a network composed of glycan strands cross-linked by stem peptides, is the main component of the CW. During PG synthesis, precursors are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26ca85a75f20e60590fba0399adf94b
https://doi.org/10.1101/2023.01.23.525174
https://doi.org/10.1101/2023.01.23.525174
Autor:
Markus Hovd, Ida Robertsen, Line Kristin Johnson, Veronica Krogstad, Christine Wegler, Kine Eide Kvitne, Marianne Kristiansen Kringen, Eva Skovlund, Cecilia Karlsson, Shalini Andersson, Per Artursson, Rune Sandbu, Jøran Hjelmesæth, Anders Åsberg, Rasmus Jansson-Löfmark, Hege Christensen
Publikováno v:
Clinical Pharmacokinetics
Introduction Rosuvastatin pharmacokinetics is mainly dependent on the activity of hepatic uptake transporter OATP1B1. In this study, we aimed to investigate and disentangle the effect of Roux-en-Y gastric bypass (RYGB) and weight loss on oral clearan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a71b5f7a1e75507663c485c5c524a8
http://hdl.handle.net/10852/102727
http://hdl.handle.net/10852/102727
Autor:
Maria Karlgren, Karolina Issa, Per Artursson, Christine Wegler, Meryem Gazit, Sujay Subramaniam
Publikováno v:
Journal of Pharmaceutical Sciences. 110:388-396
The Breast Cancer Resistance Protein (BCRP) is a key transporter in drug efflux and drug-drug interactions. However, endogenous expression of Multidrug Resistance Protein 1 (MDR1) confounds the interpretation of BCRP-mediated transport in in vitro mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d5bae62eb3a6ba326e577733489bec
https://doi.org/10.1016/j.xphs.2020.09.039
https://doi.org/10.1016/j.xphs.2020.09.039
Autor:
Per Artursson, Christel A. S. Bergström, Alexandra Teleki, David Ahl, Shno Asad, Christine Wegler, Mia Phillipson
Publikováno v:
Journal of Pharmaceutical Sciences. 110:239-250
Inflammatory bowel disease (IBD) is a chronic condition resulting in impaired intestinal homeostasis. Current practices for diagnosis of IBD are challenged by invasive, demanding procedures. We hypothesized that proteomics analysis could provide a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1063769fc514bec9fc75ad491541f58d
https://doi.org/10.1016/j.xphs.2020.11.001
https://doi.org/10.1016/j.xphs.2020.11.001
Autor:
Kine Eide Kvitne, Veronica Krogstad, Christine Wegler, Line Kristin Johnson, Marianne K. Kringen, Markus Herberg Hovd, Jens K. Hertel, Maria Heijer, Rune Sandbu, Eva Skovlund, Per Artursson, Cecilia Karlsson, Shalini Andersson, Tommy B. Andersson, Jøran Hjelmesæth, Anders Åsberg, Rasmus Jansson‐Löfmark, Hege Christensen, Ida Robertsen
Publikováno v:
British Journal of Clinical Pharmacology
Aim: Roux-en-Y gastric bypass (RYGB) may influence drug disposition due to surgery-induced gastrointestinal alterations and/or subsequent weight loss. The objective was to compare short- and long-term effects of RYGB and diet on the metabolic ratios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0241f6f84f9cf1970dd8533e1d69f15
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-495117
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-495117