Výsledky vyhledávání - "Christine Vesque"

Akademický článek

Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction

Autor: Morgane Djebar, Isabelle Anselme, Guillaume Pezeron, Pierre-Luc Bardet, Yasmine Cantaut-Belarif, Alexis Eschstruth, Diego López-Santos, Hélène Le Ribeuz, Arnim Jenett, Hanane Khoury, Joelle Veziers, Caroline Parmentier, Aurélie Hirschler, Christine Carapito, Ruxandra Bachmann-Gagescu, Sylvie Schneider-Maunoury, Christine Vesque

Publikováno v: eLife, Vol 13 (2024)

Cilia defects lead to scoliosis in zebrafish, but the underlying pathogenic mechanisms are poorly understood and may diverge depending on the mutated gene. Here, we dissected the mechanisms of scoliosis onset in a zebrafish mutant for the rpgrip1l ge

Externí odkaz: https://doaj.org/article/6d0309d8873b4fb5a587588def14f534

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Akademický článek

Centriole Translational Planar Polarity in Monociliated Epithelia

Autor: Antoine Donati, Sylvie Schneider-Maunoury, Christine Vesque

Publikováno v: Cells, Vol 13, Iss 17, p 1403 (2024)

Ciliated epithelia are widespread in animals and play crucial roles in many developmental and physiological processes. Epithelia composed of multi-ciliated cells allow for directional fluid flow in the trachea, oviduct and brain cavities. Monociliate

Externí odkaz: https://doaj.org/article/04eceb359f414458b3d769750c0fd28a

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Akademický článek

MKS-NPHP module proteins control ciliary shedding at the transition zone.

Autor: Delphine Gogendeau, Michel Lemullois, Pierrick Le Borgne, Manon Castelli, Anne Aubusson-Fleury, Olivier Arnaiz, Jean Cohen, Christine Vesque, Sylvie Schneider-Maunoury, Khaled Bouhouche, France Koll, Anne-Marie Tassin

Publikováno v: PLoS Biology, Vol 18, Iss 3, p e3000640 (2020)

Ciliary shedding occurs from unicellular organisms to metazoans. Although required during the cell cycle and during neurogenesis, the process remains poorly understood. In all cellular models, this phenomenon occurs distal to the transition zone (TZ)

Externí odkaz: https://doaj.org/article/111959731b764aa29041317dbaa14256

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Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone

Autor: Hemant Khanna, Christoph Gerhardt, Sylvie Schneider-Maunoury, Christine Vesque, Renate Dildrop, Antonia Wiegering

Publikováno v: Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2021, pp.mbc.E20-03-0190. ⟨10.1091/mbc.E20-03-0190⟩
Molecular Biology of the Cell, 2021, pp.mbc.E20-03-0190. ⟨10.1091/mbc.E20-03-0190⟩

International audience; A range of severe human diseases called ciliopathies are caused by the dysfunction of primary cilia. Primary cilia are cytoplasmic protrusions consisting of the basal body (BB), the axoneme and the transition zone (TZ). The BB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbfae4b014a113e92b103f0d2155493
https://hal.sorbonne-universite.fr/hal-03152399/file/mbc.e20-03-0190.pdf

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Planar polarization of cilia in the zebrafish floor-plate involves Par3-mediated posterior localization of highly motile basal bodies

Autor: Sylvie Schneider-Maunoury, Isabelle Anselme, Antoine Donati, Christine Vesque

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2019, 148 (13), ⟨10.1101/702282⟩

To produce a directional flow, ciliated epithelia display a uniform orientation of ciliary beating. Oriented beating requires planar cell polarity (PCP), which leads to planar orientation and asymmetric positioning of the ciliary basal body (BB) alon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0515d867f72ddebf09e51de53f7b999
https://pubmed.ncbi.nlm.nih.gov/34104942

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Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone

Autor: Christoph Gerhardt, Antonia Wiegering, Sylvie Schneider-Maunoury, Christine Vesque, Renate Dildrop

A range of severe human diseases called ciliopathies are caused by the dysfunction of primary cilia. Primary cilia are cytoplasmic protrusions consisting of the basal body (BB), the axoneme and the transition zone (TZ). The BB is a modified mother ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b405b7e15a9cfbd764f13f78edd60596

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Loss of the Reissner Fiber and increased URP neuropeptide signaling underlie scoliosis in a zebrafish ciliopathy mutant

Autor: Guillaume Pézeron, Arnim Jenett, Christine Vesque, Eschstruth A, Parmentier C, Sylvie Schneider-Maunoury, Joëlle Veziers, Ribeuz Hl, Yasmine Cantaut-Belarif, Isabelle Anselme, Djebar M, Santos Dl, H Khoury

SUMMARYCilia-driven movements of the cerebrospinal fluid (CSF) are involved in zebrafish axis straightness, both in embryos and juveniles [1, 2]. In embryos, axis straightness requires cilia-dependent assembly of the Reissner fiber (RF), a SCO-spondi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9433099b3790ac9c3cc0becba2212b91
https://doi.org/10.1101/2019.12.19.882258

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MKS-NPHP module proteins regulate ciliary shedding inParamecium

Autor: Delphine Gogendeau, Michel Lemullois, Anne Aubusson-Fleury, Olivier Arnaiz, Jean Cohen, Christine Vesque, Sylvie Schneider-Maunoury, France Koll, Anne-Marie Tassin

Ciliogenesis is a general process in eukaryotic cells and its different steps begin to be well characterised. However, the molecular mechanisms leading to decilation or ciliary shedding are still poorly understood. This process, observed from unicell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e32108c1a01a0c0faad7f8767ac958c
https://doi.org/10.1101/676395

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Cell type‐specific regulation of ciliary transition zone assembly in vertebrates

Autor: Tristan Leu, Antonia Wiegering, Andreas Struchtrup, Sophie Saunier, André Spychala, Stefanie Dahmen, Stefanie Kuschel, Christoph Gerhardt, Flora Legendre, Ulrich Rüther, Renate Dildrop, Thomas Zobel, Lisa Kalfhues, Sylvie Schneider-Maunoury, Johanna Maria Lier, Christine Vesque

Publikováno v: The EMBO Journal
EMBO Journal
EMBO Journal, 2018, 37 (10), ⟨10.15252/embj.201797791⟩

International audience; Ciliopathies are life-threatening human diseases caused by defective cilia. They can often be traced back to mutations of genes encoding transition zone (TZ) proteins demonstrating that the understanding of TZ organisation is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdaf3317bb3be7edf654c4ca11d9ed6d
https://doi.org/10.15252/embj.201797791

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Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros

Autor: Helori-Mael Gaudé, Rémi Salomon, Christine Vesque, Céline Burcklé, Flora Silbermann, Corinne Antignac, Cécile Jeanpierre, Sophie Saunier, Sylvie Schneider-Maunoury

Publikováno v: Human Molecular Genetics. 20:2611-2627

Nephronophthisis is a hereditary nephropathy characterized by interstitial fibrosis and cyst formation. It is caused by mutations in NPHP genes encoding the ciliary proteins, nephrocystins. In this paper, we investigate the function of nephrocystin-4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2fcedc776f975c02fe19926bf3b2d22
https://doi.org/10.1093/hmg/ddr164

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