Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations

Autor: Joachim Scholz, Roger B. Fillingim, David Yarnitsky, Tina Tockarshewsky, Shannon M. Smith, Dennis C. Turk, Shay Bujanover, Daniel B. Carr, Nadine Attal, Joanna M. Brell, Jeffrey Tobias, Nathaniel P. Katz, Penney Cowan, Joseph M. Scavone, Mila Etropolski, Martin S. Angst, Linda Porter, Jennifer S. Gewandter, Simon Haroutounian, Warren Wen, Robert H. Dworkin, Raymond A. Dionne, Mark Versavel, John D. Markman, Ajay D. Wasan, Christine Veasley, Lee S. Simon, Andrew S.C. Rice, Per Hansson, Robert R. Edwards, Ernest A. Kopecky, Lars Arendt-Nielsen, Amy S. Chappell, R. Baron, Bob A. Rappaport, George G. Nomikos, Laurie B. Burke, Roy Freeman

Publikováno v: PAIN Reports, Vol 6, Iss 1, p e899 (2021)
Edwards, R R, Dworkin, R H, Turk, D C, Angst, M S, Dionne, R, Freeman, R, Hansson, P, Haroutounian, S, Arendt-Nielsen, L, Attal, N, Baron, R, Brell, J, Bujanover, S, Burke, L B, Carr, D, Chappell, A S, Cowan, P, Etropolski, M, Fillingim, R B, Gewandter, J S, Katz, N P, Kopecky, E A, Markman, J D, Nomikos, G, Porter, L, Rappaport, B A, Rice, A S C, Scavone, J M, Scholz, J, Simon, L S, Smith, S M, Tobias, J, Tockarshewsky, T, Veasley, C, Versavel, M, Wasan, A D, Wen, W & Yarnitsky, D 2016, ' Patient phenotyping in clinical trials of chronic pain treatments : IMMPACT recommendations ', Pain, vol. 157, no. 9, pp. 1851-1871 . https://doi.org/10.1097/j.pain.0000000000000602
Edwards, R R, Dworkin, R H, Turk, D C, Angst, M S, Dionne, R, Freeman, R, Hansson, P, Haroutounian, S, Arendt-Nielsen, L, Attal, N, Baron, R, Brell, J, Bujanover, S, Burke, L B, Carr, D, Chappell, A S, Cowan, P, Etropolski, M, Fillingim, R B, Gewandter, J S, Katz, N P, Kopecky, E A, Markman, J D, Nomikos, G, Porter, L, Rappaport, B A, Rice, A S C, Scavone, J M, Scholz, J, Simon, L S, Smith, S M, Tobias, J, Tockarshewsky, T, Veasley, C, Versavel, M, Wasan, A D, Wen, W & Yarnitsky, D 2021, ' Patient phenotyping in clinical trials of chronic pain treatments : IMMPACT recommendations ', Pain Reports, vol. 6, no. 1, e896 . https://doi.org/10.1097/pr9.0000000000000896

There is tremendous interpatient variability in the response to analgesic therapy (even for efficacious treatments), which can be the source of great frustration in clinical practice. This has led to calls for “precision medicine” or personalized

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http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000896