Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christine V. Whiting"'
Autor:
Jennifer R Bailey, Paul W Bland, John F Tarlton, Iain Peters, Moganaden Moorghen, Paul A Sylvester, Christopher S J Probert, Christine V Whiting
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52332 (2012)
BACKGROUND: Fibrosis is a serious consequence of Crohn's disease (CD), often necessitating surgical resection. We examined the hypothesis that IL-13 may promote collagen accumulation within the CD muscle microenvironment. METHODS: Factors potentially
Externí odkaz:
https://doaj.org/article/1e7df736dc304894b52eb94c48219eca
Autor:
Maja Vurnek, John F Tarlton, Paul Jarrett, Heidi E. Koschwanez, Satya Amirapu, Elizabeth Broadbent, John Weinman, Christine V. Whiting, Sarah Colgan, David S. Long
Publikováno v:
Brain, Behavior, and Immunity. 50:47-51
Higher psychological stress is associated with slower dermal wound healing, but the immunological mechanisms behind this effect are only partially understood. This paper aims to investigate whether immune cells present in the skin prior to wounding c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46494497c1b59e1bbb5622fc083f295f
https://doi.org/10.1016/j.bbi.2015.06.011
https://doi.org/10.1016/j.bbi.2015.06.011
Publikováno v:
Journal of Investigative Dermatology. 127:958-968
Up to one million people suffer from chronic skin ulcers in the US. Little is known of the mechanisms leading to tissue breakdown, although inadequate circulation and ischemia are common elements in most dermal ulcers. Collagen is the principal sourc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7524dfec902cf1345e69f95cadbee9f
https://doi.org/10.1038/sj.jid.5700651
https://doi.org/10.1038/sj.jid.5700651
Autor:
Satya Amirapu, John F Tarlton, David S. Long, Heidi E. Koschwanez, John Weinman, Christine V. Whiting, Paul Jarrett, Sarah Colgan, Maja Vurnek, Elizabeth Broadbent
Publikováno v:
Brain, behavior, and immunity. 49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3306349328ae8db4b7dabf2c18795a
https://pubmed.ncbi.nlm.nih.gov/26234758
https://pubmed.ncbi.nlm.nih.gov/26234758
Publikováno v:
Clinical and Experimental Immunology. 147:313-323
Acute inflammation in the bowel, a response of the immune system to infections or trauma, is probably a frequent but localized event, but when the barrier is repaired and the infection cleared, it is quickly followed by wound healing and resolution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4464252d8e4c1d29760c19990d65bf10
https://doi.org/10.1111/j.1365-2249.2006.03267.x
https://doi.org/10.1111/j.1365-2249.2006.03267.x
Publikováno v:
Inflammatory Bowel Diseases. 11:340-349
Background: n-3 polyunsaturated fatty acids (PUFAs) reduce the severity of chronic inflammatory bowel disease, probably by means of reduction of immune cell activation or enhancement of the epithelial barrier. Using the severe combined immunodeficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf905d185e2868aaae33d707ade9942
https://doi.org/10.1097/01.mib.0000164016.98913.7c
https://doi.org/10.1097/01.mib.0000164016.98913.7c
Publikováno v:
Journal of Histochemistry & Cytochemistry. 51:1177-1189
Transforming growth factor-β (TGF-β) depresses mucosal inflammation and upregulates extracellular matrix (ECM) deposition. We analyzed TGF-β receptors RI and RII as well as ECM components using the CD4+T-cell-transplanted SCID mouse model of colit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fafca43e784a0d71e28bf327c1cb0578
https://doi.org/10.1177/002215540305100908
https://doi.org/10.1177/002215540305100908
Autor:
Jörg Reimann, Amanda M. Williams, Christine V. Whiting, Paul W. Bland, Soren Bregenholt, Mogens H. Claesson
Publikováno v:
Journal of Histochemistry & Cytochemistry. 49:727-738
Using a CD4+ T-cell-transplanted SCID mouse model of colitis, we have analyzed TGF-β transcription and translation in advanced disease. By in situ hybridization, the epithelium of both control and inflamed tissues transcribed TGF-β1 and TGF-β3 mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eca56450aabf9a8e40d864bc1b2f1dd
https://doi.org/10.1177/002215540104900606
https://doi.org/10.1177/002215540104900606
Autor:
David Tunmore, Søren Bregenholt, Mogens H. Claesson, Christine V. Whiting, Paul W. Bland, Jörg Reimann, John F Tarlton
Publikováno v:
The American Journal of Pathology. 157:1927-1935
Proteinases are important at several phases of physiological and pathological inflammation, mediating cellular infiltration, cytokine activation, tissue damage, remodeling, and repair. However, little is known of their role in the pathogenesis of inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4210d9dfebb859f65bb0c7d531a7ecca
https://doi.org/10.1016/s0002-9440(10)64831-6
https://doi.org/10.1016/s0002-9440(10)64831-6
Autor:
Christine V. Whiting, Mogens H. Claesson, Amanda M. Williams, Kerstin Bonhagen, Søren Bregenholt, J Reimann, Paul W. Bland
Publikováno v:
Clinical and Experimental Immunology. 116:415-424
The adoptive transfer of activated CD4+α/β T cell blasts from the spleens of immunocompetent C.B-17+/+ or BALB/cdm2 mice into C.B-17scid/scid (scid) mice induces a colitis in the scid recipient within 8 weeks, which progresses to severe disease wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b662217f07582f4c2ba13bb03c49255
https://doi.org/10.1046/j.1365-2249.1999.00915.x
https://doi.org/10.1046/j.1365-2249.1999.00915.x