Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christine T. Demaria"'
Autor:
Christine T. DeMaria, Andrew W.B. Craig, Kianoush Khaleghpour, Nahum Sonenberg, Yuri V. Svitkin, Stephen K. Burley, Rahul C. Deo
Publikováno v:
Molecular Cell. 7(1):205-216
The eukaryotic mRNA 3' poly(A) tail acts synergistically with the 5' cap structure to enhance translation. This effect is mediated by a bridging complex, composed of the poly(A) binding protein (PABP), eIF4G, and the cap binding protein, eIF4E. PABP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58e82cf8792b699a8dfe947762799e8
Publikováno v:
Journal of Biological Chemistry. 272:27635-27643
AUF1 is an RNA-binding protein that contains two nonidentical RNA recognition motifs (RRMs). AUF1 binds to A + U-rich elements (AREs) with high affinity. The binding of AUF1 to AREs is believed to serve as a signal to an mRNA-processing pathway that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f152bbd4104123de852312e3003ba1
https://doi.org/10.1074/jbc.272.44.27635
https://doi.org/10.1074/jbc.272.44.27635
Autor:
Christine T. DeMaria, Gary Brewer
Publikováno v:
Journal of Biological Chemistry. 271:12179-12184
Rapid degradation of many labile mRNAs is regulated in part by an A + U-rich element (ARE) in their 3'-untranslated regions. Extensive mutational analyses of various AREs have identified important components of the ARE, such as the nonamer motif UUAU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b89aa7bb21d8a05ba9867bfac05c68
https://doi.org/10.1074/jbc.271.21.12179
https://doi.org/10.1074/jbc.271.21.12179
Autor:
Michael R. Bristow, J. David Port, Gary Brewer, Aldo Pende, Wayne Minobe, John D. Bisognano, Christine T. DeMaria, Burns C. Blaxall, Jonathan A. Sherman, Kelli D. Tremmel
Publikováno v:
Journal of Biological Chemistry. 271:8493-8501
In both cell culture based model systems and in the failing human heart, beta-adrenergic receptors ( beta-AR) undergo agonist-mediated down-regulation. This decrease correlates closely with down-regulation of its mRNA, an effect regulated in part by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2eb441eabe04d1866362a6119916a78
https://doi.org/10.1074/jbc.271.14.8493
https://doi.org/10.1074/jbc.271.14.8493
Autor:
Eric Klann, Jessica L. Banko, Nahum Sonenberg, Christine T. DeMaria, Lingfei Hou, Francis Poulin
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(42)
Long-lasting synaptic plasticity and memory requires mRNA translation, yet little is known as to how this process is regulated. To explore the role that the translation repressor 4E-BP2 plays in hippocampal long-term potentiation (LTP) and learning a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d3b9d3f287fad231e0afe33b2d6008
https://pubmed.ncbi.nlm.nih.gov/16237163
https://pubmed.ncbi.nlm.nih.gov/16237163
Autor:
Michinori Kohara, Anne-Claude Gingras, Nahum Sonenberg, Zhidan Wu, Asao Katsume, Kyoko Tsukiyama-Kohara, Mounib Elchebly, Mary-Ellen Harper, Bruce M. Spiegelman, Alan Cheng, Christine T. DeMaria, Michel L. Tremblay, Francis Poulin
Publikováno v:
Nature medicine. 7(10)
All nuclear-encoded mRNAs contain a 5' cap structure (m7GpppN, where N is any nucleotide), which is recognized by the eukaryotic translation initiation factor 4E (eIF4E) subunit of the eIF4F complex. The eIF4E-binding proteins constitute a family of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b5b72e792ed1c2b8e25f05c5ce56c4
https://pubmed.ncbi.nlm.nih.gov/11590426
https://pubmed.ncbi.nlm.nih.gov/11590426
Publikováno v:
Genomics. 48(2)
The steady-state levels of many mRNAs are determined in part by their turnover rates. Turnover rates, in turn, are usually controlled by proteins that bind cis-acting sequence elements in mRNAs. One class of cis-acting instability determinants is com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38497b2499391c48a3bb5ff12f29d7c8
https://pubmed.ncbi.nlm.nih.gov/9521873
https://pubmed.ncbi.nlm.nih.gov/9521873
mRNA turnover is an important regulatory component of gene expression and is significantly influenced by ribonucleoprotein (RNP) complexes which form on the mRNA. Studies of human alpha-globin mRNA stability have identified a specific RNP complex (al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8af10224579f49a52e7528976f9d3ee
https://europepmc.org/articles/PMC232339/
https://europepmc.org/articles/PMC232339/
Autor:
D. Crater, Christine T. DeMaria, Wei Zhang, Gary Brewer, K. Dehaven, B. J. Wagner, Laura J. Long, Karen Ehrenman, A. W. Schaefer
The degradation of some proto-oncogene and lymphokine mRNAs is controlled in part by an AU-rich element (ARE) in the 3' untranslated region. It was shown previously (G. Brewer, Mol. Cell. Biol. 11:2460-2466, 1991) that two polypeptides (37 and 40 kDa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f0ce836856a4d00e386f0b5b3dbcc0
https://europepmc.org/articles/PMC364837/
https://europepmc.org/articles/PMC364837/
Autor:
Christine T. DeMaria, Victor Cairns, Cordula Schwarz, Jin Zhang, Megan Guerin, Erin Zuena, Scott Estes, Kenneth P. Karey
Publikováno v:
Biotechnology Progress; Apr2007, Vol. 23 Issue 2, p465-472, 8p